A5054605711- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Treatment of Major Depression
- Immune cells in cancer
- Neural dynamics and brain function
- Neurogenesis and neuroplasticity mechanisms
- Neurological Disease Mechanisms and Treatments
- RNA and protein synthesis mechanisms
- Adenosine and Purinergic Signaling
- Memory and Neural Mechanisms
- CRISPR and Genetic Engineering
- HIV-related health complications and treatments
- Bipolar Disorder and Treatment
- Intensive Care Unit Cognitive Disorders
- Gut microbiota and health
- Connexins and lens biology
- Olfactory and Sensory Function Studies
- Alzheimer's disease research and treatments
- Space Science and Extraterrestrial Life
- Zebrafish Biomedical Research Applications
- Caveolin-1 and cellular processes
- Virus-based gene therapy research
- Cytokine Signaling Pathways and Interactions
Centre Interdisciplinaire de Recherche en Biologie
2019-2025
Centre National de la Recherche Scientifique
2016-2025
Collège de France
2022-2025
Inserm
2016-2025
Université Paris Sciences et Lettres
2022-2025
CEA Paris-Saclay - Etablissement de Fontenay-aux-roses
2025
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2025
CEA Paris-Saclay
2025
University of Florence
2024
Institut du Cerveau
2016-2020
The past decade has witnessed a revolution in our understanding of microglia. These immune cells were shown to actively remodel neuronal circuits, leading propose new pathogenic mechanisms. To study microglial implication the loss synapses, best pathological correlate cognitive decline across chronic stress, aging, and diseases, we recently conducted ultrastructural analyses. Our work uncovered existence phenotype that is rarely present under steady state conditions, hippocampus, cerebral...
Selective serotonin reuptake inhibitors (SSRIs) represent the most common treatment for major depression. However, their efficacy is variable and incomplete. In order to elucidate cause of such incomplete efficacy, we explored hypothesis positing that SSRIs may not affect mood per se but, by enhancing neural plasticity, render individual more susceptible influence environment. Consequently, SSRI administration in a favorable environment promotes reduction symptoms, whereas stressful leads...
Using transcriptomics, anatomical studies, imaging and ELISA, Morin-Brureau et al. examine microglia in patients with temporal lobe epilepsies. In highly sclerotic regions such as CA1, the anti-inflammatory cytokine IL-10 regulates microglial phenotype. Seizures induce a transient phenotype associated secretion of inflammatory cytokines including human CXCL8.
Abstract Evidence for different physiological properties along the hippocampal longitudinal axis is emerging. Here, we examined electrophysiological features of neurons at dorso-ventral sites mouse CA1 region. Cell position was defined with respect to coordinates each slice. We measured variations in neuronal excitability, subthreshold membrane and neurotransmitter responses axis. found that (i) pyramidal cells dorsal hippocampus (DH) were less excitable than those ventral (VH). Resting...
Microglia exhibit multiple, phenotype-dependent motility patterns often triggered by purinergic stimuli. However, little data exist on of human microglia in pathological situations. Here we examine stained with a fluorescent lectin tissue slices from female and male epileptic patients diagnosed mesial temporal lobe epilepsy or cortical glioma (peritumoral cortex). Microglial shape varied ramified to amoeboid cells predominantly regions high neuronal loss closer tumor. Live imaging revealed...
Throughout the brain, astrocytes form networks mediated by gap junction channels that promote activity of neuronal ensembles. Although their inputs on information processing are well established, how molecular shape network patterns remains unclear. Here, using astroglial connexin-deficient mice, in which disconnected and bursting abnormal, we show astrocyte strengthen via dynamic regulation extracellular potassium levels, independently glutamate homeostasis or metabolic support. Using a...
Astrocytes form extensive networks with diverse calcium activity, yet the organization and connectivity of these across brain regions remain largely unknown. To address this, we developed AstroNet, a data-driven algorithm that uses two-photon imaging to map temporal correlations in astrocyte activation. By organizing individual activation events chronologically, our method reconstructs functional extracts local correlations. We create graph network by tallying direct co-activations between...
An increasing number of studies show that selective serotonin reuptake inhibitors (SSRIs) exert their therapeutic action, at least in part, by amplifying the influence living environment on mood. As a consequence, when administered favorable environment, SSRIs lead to reduction symptoms, but stressful conditions, they limited efficacy. Therefore, novel approaches able neutralize treatment are needed. The aim our study was test whether, mouse model depression, combined administration SSRI...
Chemokines have several physio-pathological roles in the brain. Among them, modulation of synaptic contacts and neurotransmission recently emerged as crucial activities during brain development, adulthood, upon neuroinflammation neurodegenerative diseases. CXCL16 is a chemokine normally expressed brain, where it exerts neuroprotective activity against glutamate-induced damages through cross communication with astrocytes involvement adenosine receptor type 3 (A3R) CCL2. Here we demonstrated...
The regulation of translation in astrocytes, the main glial cells brain, remains poorly characterized. We developed a high-throughput proteomics screen for polysome-associated proteins astrocytes and focused on ribosomal protein receptor activated C kinase 1 (RACK1), critical factor translational regulation. In astrocyte somata perisynaptic astrocytic processes (PAPs), RACK1 preferentially binds to number mRNAs, including Kcnj10, encoding inward-rectifying potassium (K+) channel Kir4.1. By...
Abstract Lipid homeostasis is dysregulated in some neurodegenerative diseases and after brain injuries due to excess glutamate or lack of oxygen. However the kinetics cell specificity dysregulation different groups lipids during excitotoxic neuronal death are not clear. Here we examined changes induced by injecting kainic acid ( KA ) into CA 1 region mouse hippocampus. We compared loss glial proliferation with lipid‐related transcripts markers for lipid groups, over 12 days ‐treatment. As...
Astroglial networks closely interact with neuronal populations, but their functional contribution to representation of sensory information remains unexplored. The superior colliculus (SC) integrates multi-sensory by generating distinct spatial patterns responses specific stimulation. Here, we report that astrocytes from the mouse SC form extensive in retinorecipient layer compared visual cortex. This strong astroglial connectivity relies on high expression gap-junction proteins. Genetic...
Abstract Astrocytes form extended intercellular networks, displaying complex calcium activity. However, the specific organization of these astrocytic networks and precise extent their functional connectivity in different brain areas remain unexplored. To unveil architecture we developed, using a data-driven methodology, novel algorithm called AstroNet that uses two-photon imaging to map temporal correlations activation events among neighboring astro-cytes. Our approach involves...
Brain information processing complexity is conventionally recognized as derived from neuronal activity, with neurons and their dynamic signalling responsible for the transfer of . However, brain also contains other non-neuronal cells, glial which exceed number have been largely ignored, in past, being involved processes related coding by neural networks underlying functions. Nonetheless, decisive advances characterization molecular physiological properties cells shed light on active roles...