A5042040421- Estrogen and related hormone effects
- Inflammatory mediators and NSAID effects
- Renal Diseases and Glomerulopathies
- Cancer, Stress, Anesthesia, and Immune Response
- Genetic and Kidney Cyst Diseases
- Eicosanoids and Hypertension Pharmacology
- Renal and related cancers
Hebei Medical University
2011-2024
Podocyte injury plays a critical role in the progression of diabetic kidney disease (DKD), but underlying cellular and molecular mechanisms remain poorly understanding. MicroRNAs (miRNAs) can disrupt gene expression by inducing translation inhibition mRNA degradation, recent evidence has shown that miRNAs may play key many diseases. In this study, we identified miR-4645-3p global transcriptome profiling as one major downregulated high glucose-cultured podocytes. Moreover, whether DKD...
The use of celecoxib is associated with a significant decrease in breast cancer risk. However, the long-term high-dose might be limited owing to cardiovascular side effects. In this study, we found that acetylbritannilactone (ABL), extract from Chinese medicinal herb, could reduce dose and potentiate growth-inhibitory effect cells. ABL enhanced apoptotic COX-2-expressing cells, but had little COX-2-negative apoptosis induced by combination treatment disappeared when COX-2 was knocked down,...