A5036110513- Luminescence Properties of Advanced Materials
- Cancer, Hypoxia, and Metabolism
- Glass properties and applications
- Cancer-related molecular mechanisms research
- Photonic Crystals and Applications
- RNA Research and Splicing
- Virus-based gene therapy research
- Angiogenesis and VEGF in Cancer
- Lanthanide and Transition Metal Complexes
- Solid State Laser Technologies
- Solid-state spectroscopy and crystallography
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Luminescence and Fluorescent Materials
- PI3K/AKT/mTOR signaling in cancer
- RNA modifications and cancer
- Atomic and Subatomic Physics Research
- High-pressure geophysics and materials
- Quantum optics and atomic interactions
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Health Literacy and Information Accessibility
- Enzyme Structure and Function
- Nanocluster Synthesis and Applications
- Abdominal Surgery and Complications
- Circular RNAs in diseases
Shanghai Jiao Tong University
2025
Soochow University
2024
Huizhou Central People's Hospital
2024
Shaanxi University of Science and Technology
2022-2024
Sun Yat-sen University
2017-2022
Anhui Agricultural University
2021-2022
Hong Kong Baptist University
2017-2020
Kowloon Hospital
2019
State Council of the People's Republic of China
2019
Zhejiang University
2019
The amyloid protein, Aβ, which accumulates in the brains of Alzheimer patients, is derived by proteolysis protein precursor (APP). APP can undergo endoproteolytic processing at three sites, one amino terminus Aβ domain (β-cleavage), within (α-cleavage), and carboxyl (γ-cleavage). enzymes responsible for these activities have not been unambiguously identified. By use gene disruption (knockout), we now demonstrate that TACE (tumor necrosis factor α converting enzyme), a member ADAM family...
RNA-binding proteins (RBPs) regulate the expression of thousands transcripts, and some are reported to be involved in human tumorigenesis. However, little is known about dysregulation RBPs at genomic level cancers. Here, we conducted comprehensive analyses for expression, somatic copy number alteration (SCNA), mutation profiles 1,542 ∼7,000 clinical specimens across 15 cancer types. We identified markedly dysregulated found that downregulation was a predominant pattern cancer. Combined with...
Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor that regulates expression of genes involved in O(2) homeostasis, including vascular endothelial growth (VEGF), potent stimulator angiogenesis. We sought to exploit this native adaptive response hypoxia as treatment for chronic ischemia.A hybrid protein consisting DNA-binding and dimerization domains from the HIF-1alpha subunit transactivation domain herpes simplex virus VP16 was constructed create strong, constitutive...
Adeno-associated virus (AAV) producer cell lines represent an effective method for large-scale production of AAV vectors. We set out to evaluate and characterize the use abbreviated protocol generate “masterwells” (MWs; a nonclonal population) as platform research preclinical vector production. In this system, single plasmid containing three components, sequence, rep, cap genes, selectable marker gene is stably transfected into HeLaS3 cells. Producer generating AAV2 expressing secreted form...
A unique, dual-function, photoactivatable anticancer prodrug, RuEuL, has been tailored that features a ruthenium(II) complex linked to cyclen-europium chelate via π-conjugated bridge. Under irradiation at 488 nm, the dark-inactive prodrug undergoes photodissociation, releasing DNA-damaging ruthenium species. evaluation-window (λirr = one-photon 350 nm or two-photon 700 nm), drug delivery process can be quantitatively monitored in real-time because of long-lived red europium emission. Linear...
Nanobubbles (NBs) have been utilized to enhance the removal of perfluoroalkyl and polyfluoroalkyl substances (PFAS) from water. However, effectiveness NBs under various operational conditions, including varying PFAS concentrations, pH levels, presence coexisting ions, has remained insufficiently explored. A deeper understanding these interfacial interactions is crucial optimizing maximizing efficiency in removal. This study aims bridge knowledge gaps by systematically exploring role...
Abstract DdrO is an XRE family transcription repressor that, in coordination with the metalloprotease PprI, critical DNA damage response of Deinococcus species. Here, we report crystal structure geothermalis DdrO. Biochemical and structural studies revealed conserved recognizing α-helix extended dimeric interaction protein, which are essential for promoter binding. Two oppositely charged residues HTH motif proteins form salt bridge interactions that Notably, C-terminal domain stabilized by...
Let $M$ be a closed spin manifold and $N$ codimension 1 submanifold of it. Given certain homotopy conditions, Zeidler shows that the Rosenberg index is an obstruction to existence positive scalar curvature on $M$. He further gives transfer map between K groups group $C^*$ algebras foundemental group. The maps one $N$. In this note, we present alternative formulation using algebras, give analogus result for higher theoretic signatures.
Lanthanide-doped upconversion nanoparticles (UCNPs) can convert low-energy near-infrared (NIR) light into high-energy visible light, making them valuable for broad applications. UCNPs often suffer from poor light-harvesting capabilities, which be significantly improved by incorporating organic dye antennas. However, the dye-sensitized systems are prone to severe photobleaching in an ambient atmosphere. Here, we present a synergistic approach mitigate introducing triplet state quencher...
The energy transfer (ET) between Tb3+ and Eu3+ is investigated experimentally with available theoretical models in the regime of high concentrations ≈30 nm LaPO4 nanoparticles at room temperature. ET efficiency approaches 100% even for lightly Eu3+-doped materials. major conclusion from use pulsed laser excitation switched-off continuous wave diode that migration ions, situated on La3+ sites ≈4 Å separation, not fast. quenching emission singly doped only reduces luminescence lifetime by ≈50%...
Hypoxia-inducible factor-1 (HIF-1) is a primary regulator of the physiological response to hypoxia. A recombinant adenovirus expressing constitutively active hybrid form HIF-1α subunit (Ad2/HIF-1α/VP16) being evaluated as gene therapy for treatment peripheral vascular disease. Ad2/HIF-1α/VP16 up-regulates known HIF-1-responsive genes, including those involved in angiogenesis. Expression profile analysis revealed that brain natriuretic peptide (BNP) was significantly up-regulated HIF-1α/VP16...
Abstract Although tens of thousands circular RNAs (circRNAs) have been identified in mammalian genomes, only few them characterized with biological functions. Here, we report a new approach, circScan, to identify regulatory interactions between circRNAs and RNA-binding proteins (RBPs) by discovering back-splicing reads from Cross-Linking Immunoprecipitation followed high-throughput sequencing (CLIP-seq) data. By using our method, systematically scanned ~1500 CLIP-seq datasets, ~12540 ~1090...
Heat shock protein 90 (Hsp90) plays an important role in plant developmental regulation and defensive reactions. Several species have been examined for the Hsp90 family gene. However, gene cabbage has not well investigated to date. In this study, we discovered 12 BoHsp90 genes (Brassica oleracea var. capitata L.). These B. were classified into five groups based on phylogenetic analysis. Among groups, group one contains genes, including BoHsp90-1, BoHsp90-2, BoHsp90-6, BoHsp90-10, BoHsp90-12....
Antenna-lanthanide energy transfer is investigated <italic>via</italic> a bimetallic complex with one silent and probe lanthanide ion, when their positions are interchanged in the complex.
Abstract Experimental variation of the volume ratio (filling factor: i.e., nanoparticles (NPs) compared with that medium) nanocomposite materials doped lanthanide ions demonstrates it has a significant affect upon local field effects. Lanthanum orthophosphate NPs are Eu 3+ and/or Tb and immersed in organic solvents lead borate glasses for 5 D 4 lifetime measurements. For media refractive index ( n med ) less than LaPO np = 1.79), emission decay rate increases increasing NPs, whereas >...