A5013490112- Lanthanide and Transition Metal Complexes
- Nanoplatforms for cancer theranostics
- Porphyrin and Phthalocyanine Chemistry
- Photodynamic Therapy Research Studies
- Luminescence Properties of Advanced Materials
- Advanced oxidation water treatment
- Environmental remediation with nanomaterials
- Magnetism in coordination complexes
- Radiopharmaceutical Chemistry and Applications
- Click Chemistry and Applications
- Advanced Photocatalysis Techniques
- Protist diversity and phylogeny
- Herpesvirus Infections and Treatments
- Ga2O3 and related materials
- HIV Research and Treatment
- Histiocytic Disorders and Treatments
- Ammonia Synthesis and Nitrogen Reduction
- Water Quality Monitoring Technologies
- Photoacoustic and Ultrasonic Imaging
- Nanomaterials for catalytic reactions
- Genetic and Kidney Cyst Diseases
- Supramolecular Chemistry and Complexes
- Underwater Acoustics Research
- TiO2 Photocatalysis and Solar Cells
- Chemical Synthesis and Analysis
Hong Kong Baptist University
2015-2024
University of Hong Kong
2024
Hong Kong Polytechnic University
2024
Institut Pluridisciplinaire Hubert Curien
2023
Université de Strasbourg
2023
Centre National de la Recherche Scientifique
2023
Zhongkai University of Agriculture and Engineering
2021-2023
Kowloon Hospital
2015-2017
Xi’an Jiaotong-Liverpool University
2016
State Council of the People's Republic of China
2015
A unique, dual-function, photoactivatable anticancer prodrug, RuEuL, has been tailored that features a ruthenium(II) complex linked to cyclen-europium chelate via π-conjugated bridge. Under irradiation at 488 nm, the dark-inactive prodrug undergoes photodissociation, releasing DNA-damaging ruthenium species. evaluation-window (λirr = one-photon 350 nm or two-photon 700 nm), drug delivery process can be quantitatively monitored in real-time because of long-lived red europium emission. Linear...
Highly efficient red Li<sub>3</sub>BaSrLa<sub>3</sub>(WO<sub>4</sub>)<sub>8</sub>:90at%Eu<sup>3+</sup>phosphors have been synthesized for NUV-excited WLEDs with impressive thermal stability and high purity emission.
Although lanthanide double-decker complexes with hetero-macrocyclic ligands as functional luminescent and magnetic materials have promising properties, their inferior water solubility has negated biomedical applications. Herein, four water-soluble homoleptic (Ln = Gd, Er, Yb La) sandwiches diethylene-glycol-disubstituted porphyrins (DD) are reported, structures proven by both quantum chemical calculations scanning tunneling microscopy. Our findings demonstrate that the near-infrared emission...
Cyclen-peptide bioconjugates are usually prepared in multiple steps that require individual preparation and purification of the cyclic peptide hydrophilic cyclen derivatives. An efficient strategy is discovered for cyclization functionalization toward lanthanide probe via three components intermolecular crosslinking on solid-phase synthesis with high conversion yield. Multifunctionality can be conferred by introducing different modular parts or/and metal ions cyclen-embedded cyclopeptide. As...
A novel PDT photosensitizer which features great biomedical properties can be simply prepared.
Abstract Acting as an extracellular matrix protein receptor, α V β 3 integrin becomes appealing target for photodynamic therapy of bladder cancer. Here, specific ‐integrin‐targeting porphyrinato‐gadolinium complexes (Gd‐PEG‐R n ) are demonstrated off‐on theranostic agents, where R peptides. Among them, Gd‐PEG‐R shows both impressive phototherapeutic index and robust in vivo magnetic resonance imaging (MRI) signal enhancement. Significant selectivity is proven by its high binding affinity...
A simple and direct imaging tool (<bold>HGEu001</bold>) for primary cilia based on long-lived europium luminescence is firstly presented.
Abstract Bioorthogonal chemistry is a rising field investigating chemical reactions in physiological environments with high specificity. However, only very few examples concern the real‐time monitoring of bioorthogonal by luminescence or magnetic relaxivity. To fill this gap, herein, Eu(III)‐based complex reported as small‐molecule optical imaging agent which shows off–on and provides quantitative analysis for progress reaction. The characteristic signal achieved through efficient energy...
Epstein-Barr virus (EBV) is a common human-infected related to many diseases and cancers. Recently, some peptides have been found serve targeting therapeutic roles by inhibiting EBNA1, an oncoprotein of the EBV. We herein report conjugation EBNA1-targeting porphyrins which can bring synergistic effects both introducing more specific treatments (photodynamic therapy) improving biocompatibility photosensitizer peptides. One our compounds exhibited significant photo-cytotoxicity where Lethal...
A new simian retrovirus (SRV) subtype was discovered in China and the USA from Cambodian-origin cynomolgus monkeys. Histopathological examination necropsied animals showed multifocal lymphoplasmacystic histocytic inflammation. The complete genome sequences demonstrated that US virus isolates were nearly identical (99.91–99.93 %) differed only slightly (99.13–99.16 % identical) isolate. Phylogenetic analysis formed a distinct branch of SRV-1 through -7, therefore named this subtype, SRV-8....
Abstract In this work, the shape effect of our same‐sized hybrid nanomaterials conjugated with two different Plk1‐specific peptides had been investigated in terms their photophysical properties, cellular uptake efficiencies, and selective inhibitory effects towards cancer normal cells. The results clearly indicate that spherical NaGdF 4 @SiO 2 ‐P 1 nanoparticles achieve best performance for vitro imaging, G2 phase cell arrest, and, hence, cycle inhibition.
Corroles have attracted increasing research interests in recent decades owing to their unique properties over porphyrins. However, the relatively inefficient and tedious synthetic procedures of corrole building blocks with functional groups for bioconjugation hindered bioapplications. Herein, we report a highly efficient protocol synthesize corrole-peptide conjugates good yields (up 63 %) without using prepared blocks. By condensing two -COOH-bearing-dipyrromethane molecules onto an aldehyde...
Bioorthogonal Reactions The bioorthogonal reaction provides researchers with a convenient and specific strategy to monitor complicated biological environments by simple linkage of an emitter biofunctional group. Beyond this, our turn-on signaling is utilize the group as part antenna serving lanthanide emitting center. reaction-dependent luminescent signal efficiently excludes interferences from background or unreacted emitters. See article number 2203057 Tao Zhang, Loïc J. Charbonnière,...