A5016726501- Hepatocellular Carcinoma Treatment and Prognosis
- Inflammatory Biomarkers in Disease Prognosis
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Circular RNAs in diseases
- Liver Disease Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Radiomics and Machine Learning in Medical Imaging
- Gene Regulatory Network Analysis
- MRI in cancer diagnosis
- Diffusion and Search Dynamics
- Gallbladder and Bile Duct Disorders
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Folate and B Vitamins Research
- Liver physiology and pathology
- Esophageal and GI Pathology
- Bacterial Genetics and Biotechnology
Shinshu University
2013-2025
Asahikawa Medical College Hospital
2000
MicroRNAs (miRNAs) are evolutionary conserved small RNAs that post-transcriptionally regulate the expression of target genes. To date, role miRNAs in liver development is not fully understood. By using an experimental model allows induced and controlled differentiation mouse fetal hepatoblasts (MFHs) into mature hepatocytes, we identified miR-148a as a hepatospecific miRNA highly expressed adult liver. The main finding this study revealed was critical for hepatic through direct targeting DNA...
Genetic alterations and deregulation of the miRNA biogenesis pathway components have been reported in human tumors. Tissue-specific deletion Dicer gene, which encodes an essential processing enzyme, promotes carcinogenesis animal models. These features indicate that aberrant are directly associated with cancer. For present study, we conducted quantitative RT-PCR 14 genes related to 47 paired samples primary hepatocellular carcinoma (HCC) matched non-cancerous liver. Expression seven (Dgcr8,...
Objectives: Postoperative pancreatic fistula (POPF) is the most significant and potentially lethal complication of pancreatectomy. This study evaluated association between MRI T1 mapping POPF developed a new, useful, noninvasive predictor distal pancreatectomy (DP). Methods: The included 39 patients who underwent preoperative using Modified Look-Locker Inversion Recovery Sequence (MOLLI) followed by DP January 2018 July 2024. Patients with (POPF (+), n=15) those without (-), n=24) were...
The superiority of anatomical liver resection (AR) for localized hepatocellular carcinoma (HCC) over nonanatomical (NR) remains controversial. This study aimed to investigate the impact AR in preventing local and early HCC recurrence.
Abstract Aim Methods of predicting severe postoperative complications after anatomical resection for hepatocellular carcinoma are yet to be established. We aimed clarify the relationship between inflammation‐based prognostic scores and liver fibrosis markers incidence as well usefulness these in surgical procedure selection. included 374 patients with who had undergone initial hepatectomy January 2007 December 2021. The association or was evaluated, complication rates high‐risk group defined...
Abstract Background The usefulness of inflammation‐based prognostic scores for early recurrence (ER) after hepatectomy hepatocellular carcinoma has rarely been reported. This study aimed to evaluate the potential as predictors ER and their relationship with tumor markers. Methods We enrolled 338 patients who underwent between January 2007 December 2021. Clinicopathological factors were compared developed (ER group) those did not develop (non‐ER group). association status was evaluated. These...
We propose a mathematical method to analyze the transient change in probability of gene regulation protein particle ( repressor ) for first time arrival at target operator region DNA chain. The differential equation probabilistic behavior molecular was diffusion type. expressed by modified Bessel functions. By applying Allen's approximation function, we obtained an form immediately after onset reaction. impulse response showed considerable oscillation. present result indicates genetic...
Accurate assessment of renal function prior to surgery for hepatocellular carcinoma is important patient outcome, but current methods such as the estimated glomerular filtration rate (eGFR) are inadequate. We developed a new prediction formula that incorporates preoperative computed tomography (CT) imaging data determine function.