A5014797392- RNA and protein synthesis mechanisms
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- RNA modifications and cancer
- Protein Structure and Dynamics
- Advanced Biosensing Techniques and Applications
- Enzyme Structure and Function
- Cell death mechanisms and regulation
- Acoustic Wave Resonator Technologies
- Crystal structures of chemical compounds
- Metabolomics and Mass Spectrometry Studies
- Endoplasmic Reticulum Stress and Disease
- Metal-Organic Frameworks: Synthesis and Applications
- Nonlinear Optical Materials Research
- Bacterial Genetics and Biotechnology
- Magnetism in coordination complexes
- Pneumocystis jirovecii pneumonia detection and treatment
- Single-cell and spatial transcriptomics
- Rice Cultivation and Yield Improvement
- Spectroscopy Techniques in Biomedical and Chemical Research
- Calcium signaling and nucleotide metabolism
- Synthesis and biological activity
- Advanced biosensing and bioanalysis techniques
- Lipid Membrane Structure and Behavior
- Metal complexes synthesis and properties
Albany State University
2018-2024
University at Albany, State University of New York
2018-2024
Fujian Research Institute of Light Industry
2007
Abstract Highly multiplexed detection of proteins secreted by single cells is always challenging. Herein, a in situ tagging technique based on single‐stranded DNA encoded microbead arrays and multicolor successive imaging for assaying single‐cell with high throughput sensitivity presented. This technology demonstrated to be capable increasing the multiplexity exponentially. Upon integration polydimethylsiloxane microwells, this platform applied detect ten immune effector from differentiated...
Ribosomes bind to many metabolic enzymes and change their activity. A general mechanism for ribosome-mediated amplification of enzyme activity, RAMBO, was formulated elucidated the glycolytic triosephosphate isomerase, TPI. The RAMBO effect results from a ribosome-dependent electric field-substrate dipole interaction energy that can increase or decrease ground state reactant product regulate catalytic rates. NMR spectroscopy used determine surface TPI binding ribosomes measure corresponding...
Abstract A new cobalt coordination polymer with linking unit 2-(1H-imidazole-1-yl)acetate (ima), [Co(ima)2] n (1), has been synthesized and structurally characterized by elemental analysis, IR spectra, X-ray single-crystal diffraction. The analysis indicates that a neutral 2-D (3,6) topology was obtained, which shows 3-D supramolecular network through C–H···O weak interactions. Complex 1 displays mild antimicrobial activity against Achromobacter xylosoxidans ATCC 2706, Bacillus subtilis...
Transient, site-specific, or so-called quinary, interactions are omnipresent in live cells and modulate protein stability activity. Quinary intreactions readily detected by in-cell NMR spectroscopy as severe broadening of the signals. Intact ribosome particles were shown to be necessary for that give rise signal observed cell lysates sufficient mimic quinary present crowded cytosol. Recovery target spectra broadened lysates, vitro presence purified ribosomes was achieved RNase A digestion...
A series of compounds obtained through one-pot three-component reaction, present non-centrosymmetric polar packing arrangement, resulting in strong second harmonic generation responses and ferroelectric behaviours.
Abstract Analytical tools to study cell physiology are critical for optimizing drug-host interactions. Real time pulse chase NMR spectroscopy, RTPC-NMR, was introduced monitor the kinetics of metabolite production in HEK 293T cells treated with COVID-19 vaccine-like lipid nanoparticles, LNPs, and without mRNA. Kinetic flux parameters were resolved incorporation isotopic label into metabolites clearance labeled from cells. Changes characteristic times alanine implicated mitochondrial...
NMR spectroscopy was used to investigate the phenomenon of ribosome-amplified metabolism or RAMBO between pyruvate kinase and ribosomes. Because concentration ribosomes increases as cell grows, ribosome binding interactions may regulate metabolic fluxes by altering distribution bound free enzymes. Pyruvate (PK) catalyzes last step glycolysis represents a major drug target for controlling bacterial infections. The enzymes creates protein quinary structures with altered catalytic activities....
The molecules of the title compound, C11H13N3O3, are linked by O-H center dot N and N-H O interactions into a linear hydrogen-bonded chain.