A5105924044- Colorectal Cancer Screening and Detection
- Colorectal Cancer Surgical Treatments
- Advanced biosensing and bioanalysis techniques
- Colorectal and Anal Carcinomas
- Inflammatory Bowel Disease
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Advanced Drug Delivery Systems
- COVID-19 and healthcare impacts
- RNA Interference and Gene Delivery
- Drug Solubulity and Delivery Systems
- COVID-19 Clinical Research Studies
- Biosimilars and Bioanalytical Methods
- Eosinophilic Esophagitis
- Advancements in Transdermal Drug Delivery
- Dendrimers and Hyperbranched Polymers
- Nanoparticle-Based Drug Delivery
- Anorectal Disease Treatments and Outcomes
- Infant Nutrition and Health
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gold and Silver Nanoparticles Synthesis and Applications
- Pancreatic and Hepatic Oncology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Pharmacological Effects of Natural Compounds
- Molecular Junctions and Nanostructures
Barking, Havering And Redbridge University Hospitals NHS Trust
2016-2024
Columbia University Irving Medical Center
2023-2024
Queen's Hospital
2011-2023
Birla Institute of Technology and Science, Pilani
2017-2020
Queen's Hospital
2020
Nestlé (India)
2017
Jadavpur University
2015-2016
Arizona State University
2014-2016
Tempe Union High School District
2014
Chase Farm Hospital
2010-2011
Aptameric receptors are important biosensor components, yet our ability to identify them depends on the target structures. We analyzed contributions of individual functional groups small molecules binding within 27 target-aptamer pairs, identifying potential hindrances receptor isolation-for example, negative cooperativity between sterically hindered groups. To increase probability aptamer isolation for targets, such as leucine and voriconazole, which multiple previous selection attempts...
Abstract We describe the use of a frame‐guided assembly (FGA) strategy to construct cuboid and dumbbell‐shaped hetero‐vesicles on DNA origami nanostructure scaffolds. These are achieved by varying design scaffolds that direct distribution leading hydrophobic groups (LHG). By careful selection LHGs, different types amphiphiles (both polymer small‐molecule surfactants) were guided form hetero‐vesicles, demonstrating versatility FGA its potential asymmetric dynamic hetero‐vesicle assemblies...
We reported over 20 years ago MNS-4.1, the first DNA aptamer with a micromolar affinity for cocaine. MNS-4.1 is based on structural motif that very common in any random pool of oligonucleotides, and it actually nonspecific hydrophobic receptor wide cross-reactivity alkaloids steroids. Despite such weaknesses preventing broad applications, this became widely used proof-of-concept demonstrations new formats biosensors. now report series progressively improved aptamers recognizing cocaine,...
We sought to investigate if duplicate faecal immunochemical testing (FIT) sampling improves the negative and positive predictive value of patients thought be at risk colorectal cancer (CRC). Specifically, we aimed whether proportion FIT-negative CRC missed by a single FIT test in symptomatic could reduced testing.A retrospective service evaluation cohort study diagnostic accuracy testing.Patients referred from primary care with suspected four secondary trusts North-West England.28 622 over...
To assess the impact of pilot Transnasal endoscopy (TNE) services on workforce efficiency, allocated procedure times and patient tolerance procedures. The aim was to also understand challenges setting up a TNE service. Six-month data collected from ten sites. Data captured included productivity, performance, numbers, facilities quality metrics. A survey done capture patient's experience. An eight likert-style open question designed used. Pilot sites were visited using semi-structured...
In the past National Confidential Enquiry into Peri-operative deaths (NCEPOD) have advocated a reduction in non-essential night-time operating NHS hospitals. this study retrospective analysis of emergency general surgical operative workload at London Teaching centre was performed. All and vascular operations recorded prospectively on theatre database between 1997 2004 were included study. Operations categorised according to whether they commenced during daytime(08:01–18:00 hours),...
INTRODUCTION An understanding of the volume incoming referrals to a colorectal cancer (CRC) service is essential for adequate delivery service. We hypothesised that number 2-week-wait (2WW) has increased over recent years, with concomitant increase in demand endoscopic and imaging investigations. METHODS A retrospective review all from primary care suspected malignancy Barking, Havering Redbridge NHS Trust (BHRNHST, London, UK) 2009 2014 was undertaken. Annual numbers CRC diagnoses,...
We describe the use of a frame-guided assembly (FGA) strategy to construct cuboid and dumbbell-shaped hetero-vesicles on DNA origami nanostructure scaffolds. These are achieved by varying design scaffolds that direct distribution leading hydrophobic groups (LHG). By careful selection LHGs, different types amphiphiles (both polymer small-molecule surfactants) were guided form hetero-vesicles, demonstrating versatility FGA its potential asymmetric dynamic hetero-vesicle assemblies with complex...
Abstract Aim The effectiveness of immersion training in endoscopy for surgical trainees has not been documented previously and we aimed to assess the impact at a busy gastrointestinal unit within London. This involved providing registrars with week every month, during which time their clinical duties would be covered by an appointed leadership fellow – externally funded HEE. Method Surgical currently rotating Queen’s Hospital are each enrolled assigned per month prior notice hand over...
Abstract: Aims: The aim of present study was to evaluate Gum Katira obtained from the plant Cochlospermum religiosum (Family Cochlospermaceae) as a matrix forming pharmaceutical excipient for novel drug delivery system. Materials and Methods: used release retarding material in microsphere formulation using Etodolac model drug. found be compatible with by conducting various physiochemical instrumental analysis. Result: loaded (ELGKM) compared sodium alginate (ELSAM) blank (without gum...
Background and Objective: Pioglitazone hydrochloride is a BCS Cass II drug used for hypoglycemic action which shows poor bioavailability post oral administration due to solubility in gastrointestinal fluids. The purpose of this study was prepare characterize the polymeric nanoparticles pioglitazone using polycaprolactone (PCL) as polymer effect various formulation parameters on nanoparticle characteristics. Method: Drug loaded were fabricated by nanoprecipitation method, PCL Poloxamer 188...