A5043442146- Urological Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- Ureteral procedures and complications
- Urinary Bladder and Prostate Research
- Renal and Vascular Pathologies
- Tissue Engineering and Regenerative Medicine
- Urologic and reproductive health conditions
- Renal cell carcinoma treatment
- Urinary and Genital Oncology Studies
- Bladder and Urothelial Cancer Treatments
- Organ Donation and Transplantation
- Minimally Invasive Surgical Techniques
- Prostate Cancer Diagnosis and Treatment
- Renal and related cancers
- Urinary Tract Infections Management
- Hernia repair and management
- Surgical Simulation and Training
- Sexual Differentiation and Disorders
- Prostate Cancer Treatment and Research
- Pelvic floor disorders treatments
- Congenital gastrointestinal and neural anomalies
- Testicular diseases and treatments
- Kidney Stones and Urolithiasis Treatments
- Galectins and Cancer Biology
- Botulinum Toxin and Related Neurological Disorders
Lurie Children's Hospital
2015-2024
Northwestern University
2015-2024
Columbia University Irving Medical Center
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2020
Chongqing Medical University
2020
GTx (United States)
2018
Boston Children's Hospital
2010-2013
Harvard University
2010-2013
University of Chicago Medical Center
2011
Boston University
2010
Purpose: Partial nephrectomy has been established as a standard of care for T1a renal tumors. Laparoscopic partial (LPN) described more difficult to perform than open (OPN). We compare our series LPN and OPN. Patients Methods: From October 2002 January 2006, 76 LPNs were performed patients with clinical These matched cohort who underwent OPN solitary tumors 4 cm or smaller in diameter. The cohorts compared regard demographics, perioperative data, outcomes. Results: patient populations...
Background and Purpose: Several experienced practitioners of open surgery with limited or no laparoscopic background have adopted robot-assisted radical prostatectomy (RLRP) as an alternative to (RRP), demonstrating outcomes comparable those in large RRP series. Thus, the significance prior skills seems unclear. The learning curve, respect operative time complications, hands a devoted surgeon has not been critically assessed. We evaluated curve highly achieving expertise RLRP. Patients...
We reported over 20 years ago MNS-4.1, the first DNA aptamer with a micromolar affinity for cocaine. MNS-4.1 is based on structural motif that very common in any random pool of oligonucleotides, and it actually nonspecific hydrophobic receptor wide cross-reactivity alkaloids steroids. Despite such weaknesses preventing broad applications, this became widely used proof-of-concept demonstrations new formats biosensors. now report series progressively improved aptamers recognizing cocaine,...
Diabetic bladder dysfunction (DBD) is common and affects 80% of diabetic patients. However, the molecular mechanisms underlying DBD remain elusive because a lack appropriate animal models. We demonstrate in mouse model that harbors hepatic-specific insulin receptor substrate 1 2 deletions (double knockout [DKO]), which develops type diabetes. Bladders DKO animals exhibited detrusor overactivity at an early stage: increased frequency nonvoiding contractions during filling, decreased voided...
We characterize the use of pediatric open, laparoscopic and robot-assisted ureteral reimplantation in United States from 2000 to 2012.We used Kids' Inpatient Database identify patients who underwent for primary vesicoureteral reflux. Before 2009 reimplantion were referred together as minimally invasive reimplantation. A detailed analysis open vs was performed 2012.A total 14,581 reimplantations performed. The number yearly decreased by 14.3%. However, proportion increased 0.3% 6.3%. 125 2012...
Posterior urethral valves predispose children to renal replacement therapy (RRT) and bladder dysfunction. Researchers of single-institutional series were unable refine risk stratification because rarity the disease. We aimed identify clinical variables associated with RRT clean intermittent catheterization (CIC) in a large multicenter cohort study.Children posterior born between 1995 2005 who treated before 90 days life at 5 children's hospitals retrospectively reviewed. Outcomes included...
Reoperative pyeloplasty is commonly used in children with recurrent obstruction after pyeloplasty. We previously reported on reoperative robot-assisted laparoscopic repair for failed 16 and concluded that short-term intermediate outcomes were comparable to open repair. In this updated series we describe longer term from an extended study.We retrospectively reviewed of consecutive prior primary who underwent at a single institution January 2008 June 2018.Overall, 36 0.6 15.2 years old (median...
Jamaica has the highest incidence of prostate cancer in world. Dietary fat is associated with cancer. The Omega6 polyunsaturated fatty acids have been shown to stimulate carcinogenesis and Jamaican diet rich linoleic acid. We hypothesized positive correlations between acid, specific antigen biopsy pathology.A total 148 men were enrolled Kingston, Jamaica. Serum erythrocyte membrane analyzed. Men 2.6 ng/ml or greater underwent biopsy. Histopathological statistical analyses performed on...
Fibroproliferative remodeling in smooth muscle–rich hollow organs is associated with aberrant extracellular matrix (ECM) production. Although mechanical stimuli regulate ECM protein expression, the transcriptional mediators of this process remain poorly defined. Previously, we implicated AP-1 as a mediator muscle cell (SMC) mechanotransduction; however, its role stretch-induced regulation has not been explored. Herein, identify novel for subunit FosB expression SMCs. The DNA-binding activity...
Urothelial carcinoma (UC) causes substantial morbidity and mortality worldwide. However, the molecular mechanisms underlying urothelial cancer development tumor progression are still largely unknown. Using informatics analysis, we identified Sh3gl2 (endophilin A1) as a bladder urothelium-enriched transcript. The gene encoding is located on chromosome 9p, region frequently altered in UC. known to regulate endocytosis of receptor tyrosine kinases implicated oncogenesis, such epidermal growth...