Abstract Despite the development of nomograms designed to evaluate a prostate cancer (PCa) patient's prognosis, information has been limited PSA, clinical stage, Gleason score and tumor volume estimates. We compared prognostic potential 4 histologic markers, hyaluronic acid (HA), HYAL‐1‐type hyaluronidase (HAase), CD44v6 microvessel density (MVD) using immunohistochemistry. HA is glycosaminoglycan that promotes metastasis. CD44 glycoproteins serve as cell surface receptors for HA, isoform...

Diabetic bladder dysfunction (DBD) is common and affects 80% of diabetic patients. However, the molecular mechanisms underlying DBD remain elusive because a lack appropriate animal models. We demonstrate in mouse model that harbors hepatic-specific insulin receptor substrate 1 2 deletions (double knockout [DKO]), which develops type diabetes. Bladders DKO animals exhibited detrusor overactivity at an early stage: increased frequency nonvoiding contractions during filling, decreased voided...

Lack of reliable prognostic markers hinders accurate prediction disease progression in prostate cancer. The inducible proinflammatory enzyme cyclooxygenase-2 (COX-2) is implicated carcinogenesis, but its role cancer less clear. We examined whether COX-2 expression evaluated by immunohistochemistry (IHC) radical prostatectomy (RP) specimens can predict biochemical recurrence. Archival (n = 60) were obtained from patients who underwent RP, had not received neoadjuvant hormonal therapy....

Primary dental implant stability is critical to enable osseointegration. We assessed the primary of our newly designed implant. used calf rib bone animal model. Our has an outside tapered screw with two inside barrettes that deploy a second situated at implant’s crown. ten ribs III/IV density and inserted implants per rib. deployed in rib’s transversal direction support against nearby cortical bone. measured resonance frequency analysis collected Implant Stability Quota (ISQ) transverse...

Abstract Tumor cells express HYAL1 hyaluronidase, which degrades hyaluronic acid. expression in bladder cancer promotes tumor growth, invasion, and angiogenesis. We previously described five alternatively spliced variants of that encode enzymatically inactive proteins. The HYAL1-v1 variant lacks a 30-amino acid sequence is present HYAL1. In this study, we examined whether affects growth invasion by stably transfecting HT1376 with cDNA construct. Although transfectants expressed equivalent...

OBJECTIVES To review the long‐term outcome of prostatic involvement in patients with bladder cancer (BC) treated radical cystectomy (RC), as urothelial carcinoma (UC) involving prostate occurs such patients, and invasion by UC is transmural (contiguous), or when develops from epithelium urethra (not contiguous). PATIENTS AND METHODS Between 1992 2006, 351 men had RC for BC one surgeon at our centre; they were stratified into those contiguous non‐contiguous disease, based on stromal...

No AccessJournal of UrologyAdult Urology1 Oct 2009Hyaluronic Acid and HYAL-1 in Prostate Biopsy Specimens: Predictors Biochemical Recurrenceis accompanied byPeriprostatic Adipose Tissue as a Modulator Cancer AggressivenessSemaphorin 3B 3F Single Nucleotide Polymorphisms are Associated With Risk Poor Prognosis Christopher S. Gomez, Pablo Judith Knapp, Merce Jorda, Mark Soloway, Vinata B. Lokeshwar GomezChristopher Gomez Department Urology, University Miami Miller School Medicine, Miami,...

The considerable experience of the University Miami in treating TCC is reviewed first article this section. authors found that incidence upper tract tumour after radical cystectomy for low, but patients with prostatic urethral involvement at have a greater risk developing tumours. A questionnaire‐based study UK attempted to assess how surveillance carried out by British urologists urinary TCC. They wide variation practice, which presumably similar also other parts world. recommend follow‐up...

Proforms of gastrointestinal peptides are cleaved at paired basic residues into intermediate forms. Paired the C-terminal then excised by carboxypeptidases before peptide is amidated. An obese mouse, called Cpefat/Cpefat, has a missense mutation in carboxypeptidase E (CPE) with no pancreatic CPE activity and reduced processing proinsulin to insulin. The purpose this study was 1) look for presence antrum stomach, duodenum, colon Cpefat/Cpefat mouse; 2) determine whether involved progastrin...

HYAL-1 (hyaluronoglucosaminidase-1) belongs to the hyaluronidase family of enzymes that degrade hyaluronic acid. is a marker for cancer diagnosis and molecular determinant tumor growth, invasion, angiogenesis. The regulation expression unknown. Real time reverse transcription-PCR using 11 bladder prostate cells 69 tissues showed mRNA levels are elevated 10–30-fold in cells/tissues express high activity. Although multiple transcription start sites (TSS) were detected various tissues, major...

Overweight and obesity are associated with increased cardiovascular risk. Some studies have demonstrated that they also can result in renal damage. The aim of this study was to assess the prevalence insufficiency (RI), defined as a GFR <60 ml/min per 1.73 m2, cohort 4585 patients who attended primary care essential hypertension body mass index > or =25 kg/m2. were classified overweight obese according (25 29.9 =30 kg/m2, respectively). Abdominal waist circumference =88 102 cm women men,...

The intact intervertebral disc is a six-freedom degree elastic deformation structure with shock absorption. "Ball-and-socket" TDR do not reproduce these properties inducing zygapophyseal joint overload. Elastomeric TDRs better normal kinematics, but repeated core causes its degeneration. We aimed to create new (ADDISC) reproducing healthy features. designed TDR, analyzed (Finite Element Analysis), and measured every 500,000 cycles for 10 million of the flexion-extension, lateral bending,...

BackgroundMost total disc replacements provide excessive mobility and not reproduce spinal kinematics, inducing zygapophyseal joint arthritic changes chronic back pain. In cadaveric lumbosacral spines, we studied if a new lumbar prosthesis kinematics mimics the intact intervertebral disc.MethodsIn eight cold preserved registered movement ranges in flexion, extension, right left lateral bending, rotation status, post-discectomy, after our implantation, comparing them for each...

Dental implants are designed to replace a missing tooth. Implant stability is vital achieving osseointegration and successful implantation. Although there many available on the market, room for improvement.We describe new dental implant with improved primary features.Lab bench test studies.We evaluated using static flexion-compression fatigue tests compression loads, 35 Ncm tightening torque, displacement control, 0.01 mm/s actuator movement speed, 9-10 Hz load application frequency,...

To describe a technique for concurrent radical retropubic prostatectomy (RRP) and inguinal hernioplasty, using modified Pfannenstiel incision.RRP is usually done through midline lower abdominal incision but some patients with localized prostate cancer have an hernia. Concurrent hernia repair at the time of RRP usual method only possible by either preperitoneal mesh or formal requiring additional incision(s). A 10-12 cm made along pubic hairline centred over symphysis, 'Y'-shaped in rectus...

Response to foreign materials includes local tissue reaction, osteolysis, implant loosening, and migration lymph nodes organs. Bionate 80A human explants show minor wear slight but we do not know the response at spinal cord, nerve roots, nodes, or distant This study aims figure out reactions against when implanted epidural space of 24 20-week-old New Zealand white rabbits. In one group 12 rabbits, on space, another rabbits was used as control group. We studied tissues, organs, damage markers...

Primary central nervous system lymphoma (PCNSL) rarely manifests in immunocompetent patients. In such cases, these lesions may mimic more common intracranial bleeding or tumors. We present the case of an elderly patient who presented with a presumed chronic subdural hematoma (SDH); upon surgical intervention, occult mass was discovered no evidence associated hematoma. Biopsy and immunohistochemistry demonstrated PCNSL. Literature review identified six other cases PCNSL adults that were...

cadaveric spine nucleus replacement study.determining Bionate 80A biomechanics in spines.in cold preserved spines, with ligaments and discs intact, no muscles, L3-L4, L4-L5, L5-S1 implantation was done. Differences between customized overdimensioned implants were compared. Flexion, extension, lateral bending, torsion measured the intact spine, nucleotomy, specimens. Increasing load or bending moment applied four times at 2, 4, 6, 8 Nm, twice increasing mode decreasing mode. Spine motion...