A5009253028- HIV/AIDS drug development and treatment
- Synthesis and Biological Evaluation
- Synthesis and biological activity
- RNA and protein synthesis mechanisms
- vaccines and immunoinformatics approaches
- Malaria Research and Control
- Terahertz technology and applications
- Advanced Antenna and Metasurface Technologies
- Metamaterials and Metasurfaces Applications
- Synthesis of Organic Compounds
- Cancer therapeutics and mechanisms
- Genomics and Phylogenetic Studies
- Phytochemistry and Biological Activities
- Gyrotron and Vacuum Electronics Research
- Plasmonic and Surface Plasmon Research
- Protein Degradation and Inhibitors
- Antimicrobial Peptides and Activities
- Histone Deacetylase Inhibitors Research
- Signaling Pathways in Disease
- Biological Activity of Diterpenoids and Biflavonoids
- Chemical Synthesis and Analysis
- Synthesis and Catalytic Reactions
- Microwave Engineering and Waveguides
Institut Pasteur of Shanghai
2024
University of Chinese Academy of Sciences
2024
Griffith University
2022
Suzhou University of Science and Technology
2018
Malaria, caused by Plasmodium parasites, results in >400,000 deaths annually. There is no effective vaccine, and new drugs with novel modes of action are needed because increasing parasite resistance to current antimalarials. Histone deacetylases (HDACs) epigenetic regulatory enzymes that catalyze post-translational protein deacetylation promising malaria drug targets. Here, we describe quantitative structure–activity relationship models predict the antiplasmodial activity hydroxamate-based...
Malaria is a severe disease that presents significant threat to human health. As resistance current drugs continues increase, there an urgent need for new antimalarial medications. Aminoacyl-tRNA synthetases (aaRSs) represent promising targets drug development. In this study, we identified Plasmodium falciparum tyrosyl-tRNA synthetase (PfTyrRS) as potential target development through comparative analysis of the amino acid sequences and three-dimensional structures plasmodium TyrRS, with...
Abstract Aminoacyl-tRNA synthetases (aaRSs) play a central role in the translation of genetic code, serving as attractive drug targets. Within this family, lysyl-tRNA synthetase (LysRS) constitutes promising antimalarial target. ASP3026, an anaplastic lymphoma kinase (ALK) inhibitor was recently identified novel Plasmodium falciparum LysRS ( Pf LysRS) inhibitor. Here, based on cocrystal structures and biochemical experiments, we developed series ASP3026 analogues to improve selectivity...