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Maureen L. Ruchhoeft

ORCID: 0009-0000-6643-5566
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About
Contact & Profiles
A5114303267
Research Areas
  • Sphingolipid Metabolism and Signaling
  • Metabolomics and Mass Spectrometry Studies
  • Lipid metabolism and biosynthesis
  • Peroxisome Proliferator-Activated Receptors
  • Endoplasmic Reticulum Stress and Disease

Salk Institute for Biological Studies
 2024

 Altered sphingolipid biosynthetic flux and lipoprotein trafficking contribute to trans-fat-induced atherosclerosis
OPENALEX - Publications 
Jivani M. Gengatharan Michal K. Handzlik Zoya Y Chih Maureen L. Ruchhoeft Patrick Secrest and 5 more Ethan L. Ashley Courtney R. Green Martina Wallace Philip L.S.M. Gordts Christian M. Metallo

10.1016/j.cmet.2024.10.016 article EN cc-by-nc-nd Cell Metabolism 2024-11-01
 Modeling Compound Lipid Homeostasis Using Stable Isotope Tracing
OPENALEX - Publications 
Karl A. Wessendorf-Rodriguez Maureen L. Ruchhoeft Ethan L. Ashley Hector M. Galvez Christopher W. Murray and 5 more Yi Huang Grace H. McGregor Shrikaar Kambhampati Reuben J. Shaw Christian M. Metallo

Lipids represent the most diverse pool of metabolites found in cells, facilitating compartmentation, signaling, and other functions. Dysregulation lipid metabolism is linked to disease states such as cancer neurodegeneration. However, limited tools are available for quantifying metabolic fluxes across lipidome. To directly measure reaction encompassing compound homeostasis, we applied stable isotope tracing, liquid chromatography-high-resolution mass spectrometry, network-based isotopologue...

10.1101/2024.10.16.618599 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2024-10-17
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