A5013095596- Veterinary Medicine and Surgery
- Cancer, Hypoxia, and Metabolism
- Pediatric Hepatobiliary Diseases and Treatments
- Adrenal and Paraganglionic Tumors
- Hormonal and reproductive studies
- Veterinary Pharmacology and Anesthesia
- Hormonal Regulation and Hypertension
- Growth Hormone and Insulin-like Growth Factors
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Veterinary Equine Medical Research
- Adrenal Hormones and Disorders
- Cardiac Arrest and Resuscitation
- Drug Transport and Resistance Mechanisms
- Salivary Gland Tumors Diagnosis and Treatment
- Cardiovascular Conditions and Treatments
- Heart Failure Treatment and Management
- Stress Responses and Cortisol
- Diabetes Management and Research
- Neuropeptides and Animal Physiology
- Urinary Bladder and Prostate Research
- Aldose Reductase and Taurine
- Human-Animal Interaction Studies
- S100 Proteins and Annexins
- Microbial infections and disease research
Hirslanden Klinik Aarau
2012-2023
University of Zurich
2007-2016
Background: Hypertension and proteinuria are commonly recognized in dogs with spontaneous hypercortisolism. There is, however, little information regarding the effect of exogenous glucocorticoids on blood pressure (BP) whether these changes reversible. Hypothesis: Hydrocortisone administration increases systemic BP urinary protein excretion, effects reversible after hydrocortisone withdrawal. Animals: Six control 6 treated hydrocortisone. Methods: BP, urine : creatinine ratio (UPC),...
Urinary catecholamines and metanephrines are used for the diagnosis of pheochromocytoma (PHEO) in dogs. Hyperadrenocorticism (HAC) is an important differential PHEO.To measure urinary dogs with HAC.Fourteen HAC, 7 PHEO, 10 healthy dogs.Prospective clinical trial. Urine was collected during initial work-up hospital; HAC additional sample taken at home 1 week after discharge. Parameters were measured using high-pressure liquid chromatography expressed as ratios to creatinine concentration.Dogs...
Measurement of salivary cortisol is a useful diagnostic test for hypercortisolism (HC) in humans.To determine whether measurement concentration practical alternative to plasma diagnose HC, validate the use cortisol, and examine effect time day sampling location on cortisol.Thirty healthy dogs 6 with HC.Prospective, observational clinical trial including volunteer newly diagnosed HC. Salivary concentrations were measured an immunoassay analyzer. Intra- interassay variability, linearity,...
In people, hypercortisolism (HC) has been associated with acalculous cholecystitis and biliary dyskinesia, which may potentiate ascending infections. dogs, an association between HC gallbladder disease recently documented, although the role of bacteria remains controversial. Furthermore, there is no information on bile microbial flora in healthy dogs.To investigate relationship iatrogenic hyperadrenocorticism bactibilia possible changes after cortisol withdrawal dogs.Six control dogs 6...
Canine S100 calcium-binding protein A12 (cS100A12) shows promise as biomarker of inflammation in dogs. A previously developed cS100A12-radioimmunoassay (RIA) requires radioactive tracers and is not sensitive enough for fecal cS100A12 concentrations 79% tested healthy An ELISA assay may be more than RIA does require tracers.The purpose the study was to establish a sandwich serum cS100A12, reference intervals (RI) normal canine feces.Polyclonal rabbit anti-cS100A12 antibodies were generated by...
To evaluate the effect of an adaptation period on systemic blood pressure readings, systolic was measured in 12 young adult untrained beagles over several weeks by means a Doppler flow detector and oscillometric devices. The decreased gradually significantly, levelled out after 14 days. median (range) values obtained were 166 (149 to 200) mmHg initially, 145 (119 176) day 9, 138 (118 165) 10, 127 (111 139) 35, 124 (115 143) 94 (114 142) 161. All later measurements significantly lower than...
Abstract Objective —To investigate the effects of twice-daily oral administration hydrocortisone on bile acids composition gallbladder in dogs. Animals —6 placebo-treated control dogs and 6 hydrocortisone-treated Procedures —Dogs received (median dose, 8.5 mg/kg) or a gelatin capsule (control group) orally every 12 hours for 84 days. Gallbladder samples were obtained via percutaneous ultrasound-guided cholecystocentesis from each dog before (day 0 [baseline]), during (days 28, 56, 84), after...
Background: Cats with diabetes mellitus frequently achieve clinical remission, suggesting residual β‐cell function. Responsiveness of β‐cells to arginine persists the longest during progression, making intravenous stimulation test (IVAST) a useful tool assess insulin and glucagon secretion. Hypothesis: Diabetic cats without remission will have different arginine‐induced or response. Animals: Seventeen diabetes, 7 healthy cats. Methods: Blood samples collected on admission subsequent IVAST....
To evaluate 4 methods used to measure plasma insulin-like growth factor (IGF) 1 concentrations in healthy cats and with diabetes mellitus or other diseases.39 cats, 7 mellitus, 33 diseases.4 assays preceded by different sample preparation were evaluated, including acid chromatography followed radioimmunoassay (AC-RIA), acid-ethanol extraction immunoradiometry assay (AEE-IRMA), acidification immunochemiluminescence (A-ICMA), IGF-2 excess RIA (IE-RIA). Validation of the included determination...
The development of pulmonary edema is divided in cardiogenic and non-cardiogenic. Cardiogenic pathogenically caused by elevated hydrostatic pressure the capillaries due to left sided congestive heart failure. Non-cardiogenic categorized depending on underlying pathogenesis low-alveolar pressure, permeability or neurogenic edema. Some important examples causes are upper airway obstruction like laryngeal paralysis strangulation for low alveolar leptospirosis ARDS permeability, epilepsy, brain...
Neu gibt es einen Therapieleitfaden fur Hunde und Katzen. Dieser Tierarztinnen Tierarzten Empfehlungen die Antibiotika-Behandlung ab. Er soll bei der Entscheidung helfen, ob Antibiotika notig sind wenn ja, welche verwendet werden sollen. Die Vetsuisse Fakultat, Gesellschaft Schweizer Tierarzte (GST) Schweizerische Vereinigung Kleintiermedizin (SVK) haben unter Koordination des BLV den gemeinsam erarbeitet.
Measuring C-reactive protein (CRP) in serum is a useful surrogate marker for assessing disease progression and treatment response dogs with autoinflammatory diseases. Affected often receive high-dose glucocorticoid treatment, but the effect of such alone on CRP concentrations unknown. We evaluated via immunoassay (sandwich enzyme-linked immunosorbent assay particle-enhanced turbidimetric immunoassay) 12 healthy beagle administered hydrocortisone (8 mg/kg q12 h) per os vs. placebo over 28...
An 11‐year‐old male intact Kromfohrländer dog was presented with vomiting, inappetence and progressive lethargy. Polypoid cystitis acute prostatitis were suspected. Bacterial culture of the urine revealed a bacteriuria Salmonella enterica subspecies serovar Indiana (referred to as S Indiana). Although general condition improved antibiotic treatment (enrofloxacin; 10 mg/kg/day orally osaterone acetate; 3.75 orally), still present in dog's four weeks later. Repeated antibiotics...