A5093239190- Antifungal resistance and susceptibility
- Microfluidic and Bio-sensing Technologies
- Antibiotics Pharmacokinetics and Efficacy
- 3D Printing in Biomedical Research
- Analytical Methods in Pharmaceuticals
- Microfluidic and Capillary Electrophoresis Applications
- Drug Solubulity and Delivery Systems
- Microencapsulation and Drying Processes
- Protein purification and stability
Fraunhofer Institute for Translational Medicine and Pharmacology
2023-2025
This study leverages physiologically based biopharmaceutics modeling (PBBM) to predict the clinical performance of two itraconazole (ITRA) amorphous solid dispersions (ASDs), Sempera® and Tolsura®, under fasted fed state conditions, exploring potential PBBM in predicting formulation-specific food interactions. The ITRA formulations were subjected extensive vitro biopharmaceutical testing, including solubility studies dissolution tests revealing significant differences behaviors between...
Drug release plays a crucial role in drug delivery. While current formulation approaches are capable of coarse-tuning the profile, their precision and reproducibility limited by physicochemical properties excipients active pharmaceutical ingredient (API). Innovative advanced urgently needed, especially for site-specific targeting drugs to address pharmacological requirements optimal therapy. The 5 × 0.6 mm