A5092143298- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Cardiac Ischemia and Reperfusion
- Organ Transplantation Techniques and Outcomes
University of Michigan–Ann Arbor
2023-2024
Michigan Medicine
2023
Michigan United
2023
Cold static storage and normothermic ex vivo heart perfusion are routinely limited to 6 h. This report describes intermittent left atrial (LA) that allows cardiac functional assessment in a working mode.
Introduction: Cold static storage (5C) or normothermic (37C) ex vivo heart perfusion (NEVHP) in the beating but resting mode (Langendorff) successfully preserves hearts for transplantation up to 6 hours. Previous attempts prolong preservation period increases morbidity and mortality following transplantation. In addition, 6-hour limit imposes geographic restrictions recipients, prevents optimal organ assessment, reduces number of available We have maintained 10 consecutive pediatric (60±8.8...
Introduction: Currently, to successfully transplant a heart, cardiac preservation relies on cold static storage at 5C for up 6 hours. If hearts are stored this temperature longer duration, their function after transplantation is compromised, increasing post-transplant morbidity and mortality. This time restriction negatively impacts the availability of donor limits distance transportation options, optimal cross-matching, organ assessment, all which facilitate successful transplantation....
Spencer, Brianna1; Wilhelm, Spencer1; Urrea, Kristopher1; Sewera, Sebastian1; Chakrabortty, Vikramjit1; Ho, Jamie1; Sultana, Tahmina1; Mazur, Daniel1; Bartlett, Robert H1; Pena, Alvaro Rojas1,2; Drake, Daniel D1,3 Author Information