A5051443220- Renal Diseases and Glomerulopathies
- Inflammatory Bowel Disease
- Pharmacological Effects of Natural Compounds
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Blood Pressure and Hypertension Studies
- Adolescent and Pediatric Healthcare
- Heart Rate Variability and Autonomic Control
- Systemic Lupus Erythematosus Research
- Cardiovascular Syncope and Autonomic Disorders
- Chronic Kidney Disease and Diabetes
- Immune Response and Inflammation
- Neurological diseases and metabolism
- Child and Adolescent Health
- Systemic Sclerosis and Related Diseases
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Chronic Lymphocytic Leukemia Research
- Anesthesia and Pain Management
- Sepsis Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Blood groups and transfusion
- Amyotrophic Lateral Sclerosis Research
- Botulinum Toxin and Related Neurological Disorders
Osaka University of Pharmaceutical Sciences
2022
Osaka Medical and Pharmaceutical University
2021
Kitano Hospital
2005-2014
Juntendo University Urayasu Hospital
1993
Mutations in the valosin-containing protein (VCP) gene were first found to cause inclusion- body myopathy with early-onset Paget disease and frontotemporal dementia (IBMPFD). VCP later reported occur familial amyotrophic lateral sclerosis (ALS). But role of neurodegenerative processes that ALS remains unknown. The purpose present study was elucidate neurodegeneration seen sporadic mutant ALS. Immunohistochemistry demonstrated frequency distinct VCP-positive nuclei spinal motor neurons...
Mothers of children with very-early-onset inflammatory bowel disease (VEO-IBD) face unique challenges; however, these challenges and their consequences have not been well described. This study clarified the experiences processes empowerment mothers VEO-IBD. performed a qualitative inductive analysis using semi-structured interviews. The interview content was transcribed, generating core categories, subcategories focus on raising A modified grounded theory approach employed to inductively...
The pathological role of obesity in the progression glomerular lesions has rarely been studied primary diseases. purpose this study is to investigate influence non-diabetic on clinicopathological findings IgA nephropathy.74 patients with biopsy-proven nephropathy were retrospectively divided into two groups according criteria for Japan: non-obese group (group N: n = 50) BMI <25 kg/m(2), and obese O: 24) > or =25 kg/m(2). Clinical data at time renal biopsy analyzed. Moreover, outcome...
Primary IgA nephropathy has first been described as a new disease entity almost 40 years ago. This disorder, considered to be an immune-complex-mediated glomerulonephritis, is characterized by granular deposition of (mainly IgA1) and C3 in the glomerular mesangial areas defined showing proliferative changes cells increases matrices. Apart from being one most common types chronic it also frequent case end-stage renal disease. But even though continuing efforts have gradually clarified various...
高齢者に対する硬膜外ブロックでは血圧が下降することが多く,しかもブピバカインを使用した場合はこれの心筋抑制作用のため適当な局所麻酔薬とはいえない.今回著者らは2% (0.1ml/kg),4%および6% (0.05ml/kg)のリドカインを高齢者12例の胸部硬膜外ブロックに用いたところ,2%では経過中有意に収縮期圧が下降したが,6%では安定した結果が得られた.一方,6%リドカインの血中濃度の推移を調べるため予定手術患者63例において頸部,胸部,腰部にそれぞれ0.1ml/kgを注入した結果,頸部では有意にCmax (7.6±1.3μg/ml)が高く,腰部では頸部に対し有意にTmax (8.8±2.0min)が速かった.また頸部では腰部に対し有意に低いKaを示した.以上より高齢者で少量の6%リドカイン(0.1ml/kg以下)を使用することは安全でかつ有効な方法と考えられた.