A5056139911- Radiopharmaceutical Chemistry and Applications
- Cancer, Hypoxia, and Metabolism
- Amino Acid Enzymes and Metabolism
- Click Chemistry and Applications
- Medical Imaging Techniques and Applications
- Thyroid Cancer Diagnosis and Treatment
- Lanthanide and Transition Metal Complexes
- Lung Cancer Treatments and Mutations
- Traditional Chinese Medicine Studies
- S100 Proteins and Annexins
- Receptor Mechanisms and Signaling
- Lipid metabolism and disorders
- Nitric Oxide and Endothelin Effects
- Medicinal Plants and Bioactive Compounds
- Neuropeptides and Animal Physiology
- Healthcare and Venom Research
University of Birmingham
2023-2024
Shanghai Medical College of Fudan University
1994-1997
MED Institute
1993
Abstract Purpose: Patients with aggressive thyroid cancer are frequently failed by the central therapy of ablative radioiodide (RAI) uptake, due to reduced plasma membrane (PM) localization sodium/iodide symporter (NIS). We aimed understand how NIS is endocytosed away from PM human cells, and whether this was druggable in vivo. Experimental Design: Informed analysis endocytic gene expression patients cancer, we used mutagenesis, NanoBiT interaction assays, cell surface biotinylation RAI...
Abstract New approaches are urgently needed to enhance the radioiodide (RAI) ablation of aggressive and metastatic thyroid cancer. We recently discovered that valosin-containing protein inhibitors (VCPi) such as clotrimazole disulfiram transiently block sodium iodide symporter (NIS) proteasomal degradation, hence promoting RAI uptake. However, poor bioavailability diminishes their potential impact in vivo . Following 3D modelling iterative drug design we appraised 26 novel analogues...
<p>Supplementary Figure S9</p>
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<p>This file contains Supplementary Materials and Methods, as well References.</p>
<p>Supplementary Figure S1</p>
<p>Supplementary Figure S10</p>
<p>Supplementary Figure S7</p>
<p>This file contains Supplementary Materials and Methods, as well References.</p>
<p>Supplementary Figure S3</p>
<div>AbstractPurpose:<p>Patients with aggressive thyroid cancer are frequently failed by the central therapy of ablative radioiodide (RAI) uptake, due to reduced plasma membrane (PM) localization sodium/iodide symporter (NIS). We aimed understand how NIS is endocytosed away from PM human cells, and whether this was druggable <i>in vivo</i>.</p>Experimental Design:<p>Informed analysis endocytic gene expression in patients cancer, we used mutagenesis,...
<p>Supplementary Figure S11</p>
<p>Supplementary Figure S9</p>