A5001837595- Radiopharmaceutical Chemistry and Applications
- Cancer, Hypoxia, and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Amino Acid Enzymes and Metabolism
- Click Chemistry and Applications
- Medical Imaging Techniques and Applications
- S100 Proteins and Annexins
- RNA modifications and cancer
- Thyroid Disorders and Treatments
- Neuroblastoma Research and Treatments
- Ubiquitin and proteasome pathways
- Lung Cancer Treatments and Mutations
- Radiation Therapy and Dosimetry
- Nitric Oxide and Endothelin Effects
- Pituitary Gland Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Lanthanide and Transition Metal Complexes
- Neuroendocrine Tumor Research Advances
- Cancer-related Molecular Pathways
- Cancer Research and Treatments
- Nuclear Physics and Applications
- RNA Research and Splicing
- Cancer-related gene regulation
- Electron Spin Resonance Studies
University of Birmingham
2016-2023
AstraZeneca (United Kingdom)
2023
Instituto de Investigaciones Biomédicas Sols-Morreale
2022
Universidad Autónoma de Madrid
2022
Northern General Hospital
1998
University of Sheffield
1998
Centre Hospitalier Universitaire de Grenoble
1990
Fondation pour la Recherche Médicale
1990
University of Pittsburgh
1990
Scripps Health
1990
Abstract Human antigen R (HuR) is a ubiquitously expressed RNA-binding protein, which functions as an RNA regulator. Overexpression of HuR correlates with high grade tumours and poor patient prognosis, implicating it attractive therapeutic target. However, effective small molecule antagonist to for clinical use remains elusive. Here, single domain antibody (VHH) that binds low nanomolar affinity was identified shown inhibit binding RNA. This VHH used engineer TRIM21-based biological PROTAC...
Abstract The sodium iodide symporter (NIS) is required for uptake, which facilitates thyroid hormone biosynthesis. NIS has been exploited over 75 years in ablative radioiodine (RAI) treatment of cancer, where its ability to transport radioisotopes depends on localization the plasma membrane. advent NIS-based vivo imaging and theranostic strategies other malignancies disease modalities recently increased clinical importance NIS. However, trafficking remains ill-defined. Here, we used tandem...
Thyroid cancer recurrence is associated with increased mortality and adverse outcomes. Recurrence risk currently predicted using clinical tools, often restaging patients after treatment. Detailed understanding of at disease onset could lead to personalized improved patient care.We aimed perform a comprehensive bioinformatic experimental analysis 3 levels genetic change (mRNA, microRNA, somatic mutation) apparent in recurrent tumors construct new combinatorial prognostic model.We analyzed The...
Abstract Head and neck squamous cell carcinoma (HNSCC) is the 6th most common cancer worldwide poses a significant health burden due to its rising incidence. Although proto-oncogene pituitary tumor–transforming gene 1 (PTTG) predicts poor patient outcome, mechanisms of action are incompletely understood. We show here that protein PBF modulates PTTG function, overexpressed in HNSCC tumors, correlates with significantly reduced survival. Lentiviral shRNA attenuation or expression cells either...
The sodium iodide symporter (NIS) functions to transport and is critical for successful radioiodide ablation of cancer cells. Approaches bolster NIS function diminish recurrence post-radioiodide therapy are impeded by oncogenic pathways that suppress NIS, as well the inherent complexity regulation. Here, we utilize in high-throughput drug screening undertake rigorous evaluation lead compounds identify target key processes underpinning function. We find multiple proteostasis pathways,...
Abstract Thyroid cancer is the most common primary endocrine malignancy in adults and its incidence rapidly increasing. Long non-coding RNAs (lncRNAs), generally defined as RNA molecules longer than 200 nucleotides with no protein-encoding capacity, are highly tissue-specific that serve important roles gene regulation through a variety of different mechanisms, including acting competing endogenous (ceRNAs) ‘sponge’ microRNAs (miRNAs). In present study, using an integrated approach...
Abstract Purpose: Patients with aggressive thyroid cancer are frequently failed by the central therapy of ablative radioiodide (RAI) uptake, due to reduced plasma membrane (PM) localization sodium/iodide symporter (NIS). We aimed understand how NIS is endocytosed away from PM human cells, and whether this was druggable in vivo. Experimental Design: Informed analysis endocytic gene expression patients cancer, we used mutagenesis, NanoBiT interaction assays, cell surface biotinylation RAI...
Background: The ability of thyroid follicular epithelial cells to accumulate iodide via the sodium/iodide symporter (NIS) is exploited successfully treat most cancers, although a subset patients lose functional NIS activity and become unresponsive radioiodide therapy, with poor clinical outcome. Our knowledge regulation remains limited, however. While numerous membrane proteins are functionally regulated dimerization, there little definitive evidence whether this might impact upon uptake...
Summary A 34-year-old woman presented to the out-patient clinic with angioedema and type II hereditary was confirmed immunologically. She also volunteered she had never a menstrual period physical examination identified several features of Turner's syndrome. mosaic karyotype XY XO found on chromosomal analysis gonadectomy performed in view high risk gonadoblastoma. After commencing oestrogen at physiological replacement doses, patient experienced marked deterioration both severity frequency...
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<p>This file contains Supplementary Materials and Methods, as well References.</p>
<p>Supplementary Figure S1</p>