A5006421283- Hydrogels: synthesis, properties, applications
- Computational Drug Discovery Methods
- Protein Structure and Dynamics
- Biotin and Related Studies
- Advanced Polymer Synthesis and Characterization
- thermodynamics and calorimetric analyses
- CRISPR and Genetic Engineering
- Nanoparticle-Based Drug Delivery
- SARS-CoV-2 and COVID-19 Research
- Cholinesterase and Neurodegenerative Diseases
- Viral Infectious Diseases and Gene Expression in Insects
- Monoclonal and Polyclonal Antibodies Research
- Virus-based gene therapy research
- Click Chemistry and Applications
University of Cambridge
2023-2025
Indian Institute of Chemical Biology
2022
Nanogels offer unique advantages, like high surface-to-volume ratio, scalable synthetic methods, and easily tailored formulations, that allow us to control size introduce stimuli-responsive properties. Their potential for drug delivery is significant due their biocompatibility, loading capacity, controlled sustained release. The development of greener sustainable processes essential large-scale applications. We report the synthesis in water covalently cross-linked acrylamide-based nanogels,...
ABSTRACT The oligodendrocyte‐derived membrane protein Nogo‐A is one of the most potent inhibitors neurite growth and regeneration in adult mammalian central nervous system (CNS). It has been recently shown that administration an antibody targeting promoted functional histopathological recovery animal models multiple sclerosis (MS), amyotrophic lateral (ALS), spinal cord injury (SCI) stroke. Based on these results, this study aims to develop rationally designed nanobodies target for...
Nanogels offer unique advantages, like high surface-to-volume ratio, scalable synthetic methods and easily tailored formulations, that allow to control size introduce stimuli-responsive properties. Their potential for drug delivery is significant due their biocompatibility, loading capacity, controlled sustained release, but the development of greener sustainable processes, in particular replacement organic solvents with water, essential large-scale applications. Here we report our results...
Nanogels offer unique advantages, like high surface-to-volume ratio, scalable synthetic methods and easily tailored formulations, that allow to control size introduce stimuli-responsive properties. Their potential for drug delivery is significant due their biocompatibility, loading capacity, controlled sustained release, but the development of greener sustainable processes, in particular replacement organic solvents with water, essential large-scale applications. Here we report our results...
Abstract The chemical modification of proteins is one the major mechanisms used to regulate properties and functions these macromolecules in cell. It therefore great interest develop tools exploit this type modifications for applications molecular biology, medicine biotechnology. Here we present a method using antibodies perform post-translational covalent endogenous complex environments by exploiting proximity-driven chemistry. based on ability hold weakly reactive group close its intended...
<title>Abstract</title> Alzheimer’s disease is characterized by the aggregation of Aβ peptide into amyloid fibrils. According to hypothesis, targeting pharmacologically could result in disease-modifying treatments. The identification inhibitors aggregation, however, complicated complex technical challenges, which typically restrict tens thousands number compounds that can be screened experimental assays. Here, we report a computational route increase 4 orders magnitude screenable compounds....
Abstract The chemical modification of proteins is one the major mechanisms used to regulate trafficking and function these macromolecules in cell. It therefore great interest develop tools exploit this type modifications for applications molecular biology, medicine biotechnology. Here we present a method using antibodies perform post-translational covalent endogenous complex environments by exploiting proximity-driven chemistry. based on ability hold weakly reactive group adjacently its...