A5101668815- RNA modifications and cancer
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- Cancer, Stress, Anesthesia, and Immune Response
- Antibiotic Resistance in Bacteria
- Bone Metabolism and Diseases
- Phenothiazines and Benzothiazines Synthesis and Activities
- Glycosylation and Glycoproteins Research
- Phytochemical Studies and Bioactivities
- Algal biology and biofuel production
- MicroRNA in disease regulation
- Antibiotics Pharmacokinetics and Efficacy
- Immune cells in cancer
- RNA Research and Splicing
- Cytokine Signaling Pathways and Interactions
- Circular RNAs in diseases
- Rheumatoid Arthritis Research and Therapies
- Axon Guidance and Neuronal Signaling
- Machine Learning in Bioinformatics
- Lung Cancer Treatments and Mutations
- Bone health and treatments
- Phytochemistry and Bioactive Compounds
- Alzheimer's disease research and treatments
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
Fourth Affiliated Hospital of Guangxi Medical University
2025
Gansu University of Traditional Chinese Medicine
2023
Shanghai Jiao Tong University
2022
State Key Laboratory of Biotherapy
2014-2022
Sichuan University
2014-2022
State Key Laboratory of Oncogene and Related Genes
2022
Renji Hospital
2022
Ningbo University
2020
Nanjing University
2019
Xidian University
2019
Here, we investigated the molecular mechanism underlying changes in distribution of nucleolin. Our study identified PI3K/Akt signaling as an essential pathway regulating Furthermore, nucleolin can interact with phospho‐PI3K‐p55, and were related to its phosphorylation. Subsequently, analyzed correlation VEGF nucleolin, found that metastatic potential. Finally, blocking cell surface influences process epithelial–mesenchymal transitions. This indicates may be a novel cancer therapy target...
Myeloid-derived suppressor cells (MDSCs) have been demonstrated to suppress antitumor immunity and induce resistance PD-1/PD-L1 blockade immunotherapy in gastric colon cancer patients. Herein, we found that MDSCs accumulate mice bearing syngeneic cancer. Death receptor 5 (DR5), a of TNF-related apoptosis-inducing ligand (TRAIL), was highly expressed on cells; targeting DR5 using agonistic anti-DR5 antibody (MD5-1) specifically depleted induced enrichment CD8+ T lymphocytes tumors exhibited...
N-glycosylation is one of the most important protein modifications in eukaryotes. It has been well established that plays multiple roles regulating stress tolerance plants. However, effects and mechanism on photosynthesis have not understood. In present study, an obvious decrease photosynthetic capacity dry mass were detected alg3-3 cgl1-1, two typical mutants process. The maximal photochemical efficiency PSII decreased significantly cgl1-1. values effective quantum yield photochemistry,...
Although radiation therapy is the primary treatment for nasopharyngeal carcinoma, radioresistance remains a major obstacle to successful in many cases, and exact underlying molecular mechanisms are still ill-defined. EMP2, epithelial membrane protein-2, was recently identified potential oncogene involved multiple biological processes including cell migration proliferation. This study explore relationship between EMP2 expression, carcinoma genesis, radioresistance. expression status 98...
Biot2 is a tumor-associated antigen, and it novel gene (GenBank EF100607) that was first identified with the SEREX technique named by our laboratory. It highly expressed in cancer cells testis, low or no expression normal tissues. In previous study, RNA interference of human can inhibit tumor cell growth, associated poor prognosis patients clinical study; however, mechanism effects growth not yet clear. Here, this we explore further silencing CT26 cells. provides some theoretical basis for...
Objective To investigate the expression of serum CA153 in patients with ovarian cancer and its clinical significance. Methods The preoperative levels CA125 from 49 （group A） 62 benign lesions B） were retrospectively analyzed then compared postoperative pathological findings. Results level was significantly higher than those lesions. sensitivity for diagnosing 40.827% specificity 96.77%. that （P〈O.05）. Serum increased as progress FIGO stage, but decreased differentiation tumor cells. positive...