A5090788868- Cancer Research and Treatments
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Endometrial and Cervical Cancer Treatments
- RNA modifications and cancer
- Virus-based gene therapy research
- Molecular Biology Techniques and Applications
- Ovarian cancer diagnosis and treatment
- Reproductive tract infections research
- RNA Research and Splicing
- Cancer Mechanisms and Therapy
- Protein Degradation and Inhibitors
- Advanced Biosensing Techniques and Applications
- CRISPR and Genetic Engineering
- RNA Interference and Gene Delivery
- Endoplasmic Reticulum Stress and Disease
- Bacteriophages and microbial interactions
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
- Phytoestrogen effects and research
- Nail Diseases and Treatments
- Estrogen and related hormone effects
- Monoclonal and Polyclonal Antibodies Research
- Pelvic floor disorders treatments
- Cancer-related molecular mechanisms research
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2024
Tianjin University of Traditional Chinese Medicine
2024
Guangzhou Medical University
2008-2024
Guangzhou First People's Hospital
2008-2024
<i>Aims:</i> To determine the effects of gonadotropin-releasing hormone agonist (GnRH-a) and an extended-interval dosing regimen in treatment patients with adenomyosis endometriosis. <i>Methods:</i> This was a prospective observational study setting hospital outpatient clinic. Seventy women suffering from endometriosis were randomly divided into 2 groups: (experimental group) conventional (control group). Patients experimental group received 4-dose (triptorelin 3.75...
Ovarian cancer is a possibly lethal gynecological malignancy and this study utilized phage display technology to screen identify peptides that specifically bind ovarian cells explored the effects of these on in vitro vivo. The displayed peptide library was used isolate binding internalizing into carcinoma cells. Positive clones were characterized with DNA sequencing bioinformatics analysis then validated immunofluorescence. Subsequently, selected investigated for their cancer-related...
Background Paclitaxel is recommended as a first-line chemotherapeutic agent against ovarian cancer, but drug resistance becomes major limitation. The key molecule or mechanism associated with paclitaxel in cancer still remains unclear. Recent studies have revealed an association between autophagy and resistance. Methods We previously synthesized MAPK kinase-recombinant fusion protein, MAP2K6-FP, that contains 3 domains: protein transduction domain TAT, human HO8910 cell-specific binding...
ABSTRACT Vulvovaginal candidiasis (VVC) is a common condition among women. Fluconazole remains the dominant treatment option for VVC. Oteseconazole highly selective inhibitor of fungal CYP51. This randomized, double-blinded, phase 3 trial was conducted to evaluate efficacy and safety oteseconazole compared with fluconazole in treating severe Female subjects presenting vulvovaginal signs symptoms score ≥7 positive Candida infection determined by potassium hydroxide test or Gram staining were...
Abstract Aim To investigate the expression and function of actin gamma 1 (ACTG1) in ovarian cancer. Methods We performed immunohistochemical staining 176 cancer tissue samples a human microarray to detect ACTG1. Staining intensity was examined relation clinicopathological parameters. prognostic value ACTG1, ACTG1 mRNA data from 300 patients The Cancer Genome Atlas database were examined. Results results demonstrated that levels reduced examined, negatively correlated with various Levels also...
Biologically active peptides and proteins are novel agents that show promise in the development of anticancer drugs. Their relatively low cell permeability poor tumor selectivity, however, impede their widespread applicability. In this study, we evaluated cellular internalization, biological activity a cell-permeable ovarian cancer cell-specific therapeutic protein consisting TAT-OSBP constitutively MKK6(E), an upstream kinase p38 signaling pathway mediates apoptosis. OSBP, 7-amino-acid...
<title>Abstract</title> Background In this multicenter, double-blind, randomized, parallel-group study, the efficacy and safety of levornidazole disodium phosphate for treatment women with pelvic inflammatory disease (PID) were compared. Methods The from 12 hospitals in China received a 14-day course intravenous at 0.5 g twice day (Group A, n = 49) or 1.0 once B, C, 46). Results Overall, 144 patients full analysis set (FAS), 91.00% (n 131) included per-protocol set; further, 38 these cases...
Objective To investigate the expression of serum CA153 in patients with ovarian cancer and its clinical significance. Methods The preoperative levels CA125 from 49 （group A） 62 benign lesions B） were retrospectively analyzed then compared postoperative pathological findings. Results level was significantly higher than those lesions. sensitivity for diagnosing 40.827% specificity 96.77%. that （P〈O.05）. Serum increased as progress FIGO stage, but decreased differentiation tumor cells. positive...
Objective To investigate the effects of 2-methoxyestrodial (2-ME)on apoptosis human ovarian cancer cells and explore its mechanisms.Methods Human cell line OVCAR-3 primary cultured were treated with 2-ME.Cell viability was examined by MTT as-say.Apoptosis determined Annexin V-FITC/PI staining flow cytometry.Mitochondrial membrane potential(△Ψm)was analyzed JC-1 cytometry.Caspase-3 caspase-8 activity measured colorimetric assay kits.Results 2-ME inhibited in cells(100%vs70.5%)and cells(100%vs...
Objective To investigate the expression and significance of matrix metalloproteinase-2 (MMP-2) tissue inhibitor (TIMP-2) in ectopic eutopic endometrium adenomyosis. Methods Semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) was used to determine mRNA MMP-2 TIMP-2 from 42 patients who received panhysterectomy for adenomyosis (AM group AM group), 32 uterine myoma (normal control The First Municipal People's Hospital Guangzhou February 2006 September 2007. Results ①The...
Objective To study the expression of epidermal growth factor receptor (EGFR) in cervical car-cinoma and intraepithelial neoplasia(CIN),and to elucidate its relation with genesis, infiltration, metas-tasis prognosis carcinoma. Methods EGFR was determined by means S-P immunohistochemistry tissue 100 cases carcinoma,60 CIN 40 controls. Results The overexpression rates were 0% (0/40), 51.67% (31/60),78.00% (78/100), respectively normal epithelium, tumor tissues. rate significantly higher than...
Objective To investigate the effects of gonadotropin releasing hormone analogues (GnRHa) on apoptosis cultured adenomyosis (AM) endometrial cells. Methods Eutopic cells from 32 women who received hysterectomy for AM (study group) and 20 ovarian cyst surgery benign epithelial tumor (control gynaecoiogy department in our hospital were vitro. Apoptotic ratio was detected by terminal deoxynucleotidyl transferase-mediated Dutp nick end labeling (TUNEL) flow cytometry before after using GnRHa(10-7...
Objective To examine the expression of cell apoptosis repressor factor, Bcl-2 protein, celluar nucleus related antigen, Ki-67 estrogen receptor (ER) and progesterone ( PR ) in eutopic ectopic endometrium adenomyosis normal endometrium, explore pathogenisis adenomyosis. Methods PicTure TM immunohistochemical staining technique was used to Bcl-2protein, ER 40 38 endometrium. The correlation among these factors analyzed by Spearman. Results (1) antigen showed obviously cyclic change. level them...
Objective To observe the expression of matrix metalloproteinase-7(MMP-7)and tissue inhibitors metalloproteinase-1(TIMP-1)in adenomyosis. To explore correlation between MMP-7 and TIMP-1 in adenomyosis, to study possible role pathogenesis adenomyosis. Methods The 78 ectopic eutopic endometrium adenomyosis were detected by immunohistochemical methods comparison with 80 normal endometrium. Results ① levels tissues significantly higher than those endometrium(P<0. 05). ②The on...
Objective To observe the expression of E-cadherin and CD44 v6 in human adenomyosis.To explore correlation between pathogenesis adenomyosis. Methods The CD44v6 50 ectopic eutopic endometrium adenomyosis was detected by immunohistochemical method comparison with 30 normal endometrium. Results were analyzed SPSS13.0 statistical software.Results The is lower than that endometrium(P 0.05). Conclusion The abnormal has relationship etiology adenomyosis. Key words:...