A5019967175- Electron and X-Ray Spectroscopy Techniques
- Advanced Electron Microscopy Techniques and Applications
- Machine Learning in Materials Science
- Extracellular vesicles in disease
Harvard University
2024
Center for Pain and the Brain
2024
Lunenfeld-Tanenbaum Research Institute
2024
Connectomics provides essential nanometer-resolution, synapse-level maps of neural circuits to understand brain activity and behavior. However, few researchers have access the high-throughput electron microscopes necessary generate enough data for whole circuit or reconstruction. To date, machine-learning methods been used after collection images by microscopy (EM) accelerate improve neuronal segmentation, synapse reconstruction other analysis. With computational improvements in processing...
Delivering medical agents to diseased tissues has been challenging, leading researchers study the in vivo transport process body for improving delivery. Many imaging techniques exist mapping distribution of agent-carrying nanoparticles tissues, but they cannot capture three-dimensional context with single nanoparticle resolution. Here, we developed 3DEM-NPD, a electron microscopy (3D EM) machine learning strategy image and map distributions (NPD) tissues. 3DEM-NPD provides unbiased...