A5073137849- Pluripotent Stem Cells Research
- Congenital heart defects research
- Single-cell and spatial transcriptomics
- Tissue Engineering and Regenerative Medicine
- CRISPR and Genetic Engineering
- 3D Printing in Biomedical Research
University of Nottingham
2023-2025
Queen's Medical Centre
2025
Abstract Cell-fate decisions during mammalian gastrulation are poorly understood outside of rodent embryos. The embryonic disc pig embryos mirrors humans, making them a useful proxy for studying gastrulation. Here we present single-cell transcriptomic atlas gastrulation, revealing cell-fate emergence dynamics, as well conserved and divergent gene programs governing early porcine, primate, murine development. We highlight heterochronicity in extraembryonic cell-types, despite the broad...
Highlights•A Vent gene from an acorn worm possesses Nanog-like programming activity•The a sea anemone supports self-renewal but fails to reprogram•Vent and Nanog activities appear sub-functionalize in vertebrates•Nanog activity evolves coincidently with the evolution of mesodermSummaryFrancois Jacob proposed that evolutionary novelty arises through incremental tinkering pre-existing genetic mechanisms. Vertebrate was predicated on pluripotency, ability embryonic cells form somatic germ...
Abstract Early mammalian gastrulation’s cell-fate decisions are poorly understood due to difficulties obtaining non-rodent embryos. The bilaminar disc of pig embryos mirrors humans, making them a useful proxy for studying gastrulation. Here we present single-cell transcriptomic atlas gastrulation, revealing emergence dynamics, as well conserved and divergent gene programs governing early porcine, primate, murine development. We highlight heterochronicity in extraembryonic cell-type...