A5066532180- Cardiac electrophysiology and arrhythmias
- Neuroscience of respiration and sleep
- Heart Rate Variability and Autonomic Control
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Animal testing and alternatives
- ECG Monitoring and Analysis
- Anesthesia and Neurotoxicity Research
- Spaceflight effects on biology
- Analytical Methods in Pharmaceuticals
- High Altitude and Hypoxia
- Pesticide Residue Analysis and Safety
- Ion channel regulation and function
- Nitric Oxide and Endothelin Effects
- Cardiac Ischemia and Reperfusion
- Pluripotent Stem Cells Research
- Cardiac pacing and defibrillation studies
- Computational Drug Discovery Methods
- 3D Printing in Biomedical Research
- Poisoning and overdose treatments
- Antibiotics Pharmacokinetics and Efficacy
- Stress Responses and Cortisol
- Reproductive Biology and Fertility
- Pharmaceutical studies and practices
AbbVie (United States)
2018-2025
Abbott (United States)
2018
Covance (United States)
2008-2016
University of Missouri
1996-2008
Carnegie Institution for Science
2006
Carnegie Observatories
2006
University of Colorado Health
2004
University of Arkansas at Fayetteville
1987
The role of gamma-aminobutyric acid (GABA) in homeostatic control the brainstem, particular, nucleus tractus solitarius (NTS), is well established. However, to date, there no detailed description distribution GABAergic neurons within NTS. goal current study was reexamine efficacy immunohistochemical localization glutamic decarboxylase (GAD) protein, specifically 67-kDa isoform (GAD67), as a marker for medulla and provide map GAD67-immunoreactive (-ir) cells rat NTS by using recently...
The paraventricular nucleus (PVN) of the hypothalamus is an important site for autonomic and neuroendocrine regulation. Experiments in anesthetized animals vitro indicate interaction among gamma-aminobutyric acid (GABA), nitric oxide (NO), glutamate PVN. cardiovascular role PVN interactions these neurotransmitters conscious have not been evaluated fully. In chronically instrumented rats, mean arterial pressure (MAP) heart rate (HR) responses to microinjections (100 nl) region were tested....
Abstract Following an observation of myocardial toxicity in rats with experimental TYK2 inhibitor (ABBV-712), investigative studies were performed to identify the mechanism. Telemetry-instrumented administered ABBV-712 or without atenolol investigate effects co-dosing on hemodynamic parameters and cardiac pathology. In vitro included cytotoxicity assessment human induced pluripotent stem cell-derived cardiomyocytes relaxation isolated rat aorta. Off-target pharmacology was evaluated by...
The effect of cardiovascular deconditioning on baroreflex control the sympathetic nervous system was evaluated after 14 days hindlimb unloading (HU) or condition. Rats were chronically instrumented with catheters and nerve recording electrodes for measurement mean arterial pressure (MAP) heart rate (HR) lumbar (LSNA) renal (RSNA) activity. Experiments conducted 24 h surgery, animals in a normal posture. Baroreflex function assessed using logistic that related HR LSNA RSNA to MAP during...
The Health and Environmental Sciences Institute (HESI) Cardiac Safety Committee designed created a publicly accessible database with an initial set of 128 pharmacologically defined pharmaceutical agents, many known cardiotoxic properties. includes specific information about each compound that could be useful in evaluating hypotheses around mechanisms drug-induced cardiac toxicity or for development novel cardiovascular safety assays. Data on the compounds was obtained from published...
Glutamate is the proposed neurotransmitter of baroreceptor afferents at level nucleus solitary tract (NTS). Blockade ionotropic glutamate receptors with kynurenic acid blocks arterial baroreflex but, paradoxically, does not abolish response to exogenous glutamate. This study tested hypothesis that in NTS activates both and metabotropic (mGluRs). In urethan-anesthetized rats, unilateral microinjections into decreased mean pressure, heart rate, lumbar sympathetic nerve activity. The...
The effect of thyroid status on arterial baroreflex function and autonomic contributions to resting blood pressure heart rate (HR) were evaluated in conscious rats. Rats rendered hyperthyroid (Hyper) or hypothyroid (Hypo) with triiodothyronine propylthiouracil treatments, respectively. Euthyroid (Eut), Hyper, Hypo rats chronically instrumented measure mean (MAP), HR, lumbar sympathetic nerve activity (LSNA). Baroreflex was the use a logistic that relates LSNA HR MAP during infusion...
Exposure to a period of microgravity or bed rest produces several physiological adaptations. These changes, which include an increased incidence orthostatic intolerance, have impact when people return 1G environment resume upright posture. Compared with males, females appear more susceptible intolerance after exposure real simulated microgravity. Decreased arterial baroreflex compensation may contribute intolerance. We hypothesized that female rats would exhibit greater reduction in function...
Glutamate is the proposed neurotransmitter of baroreceptor afferents at level nucleus tractus solitarius (NTS). Exogenous glutamate in NTS activates neurons through ionotropic and metabotropic receptors (mGluRs). This study tested hypothesis that group I mGluRs produce depressor, bradycardic, sympathoinhibitory responses. In urethan-anesthetized rats, unilateral 30-nl microinjections I-selective mGluR agonist 3,5-dihydroxyphenylglycine (DHPG) into decreased mean arterial pressure, heart...
Multipotent self-renewing stem cell lines have been established using peripheral blood mononuclear cells from adult green fluorescent protein transgenic swine. These proliferate as nonadherent spheroids in primordial-specific culture media and readily differentiate into angiogenic, osteogenic, adipogenic, neurogenic phenotypes when cultured under the appropriate conditions. are designated blood-derived multipotent progenitor (PBD-MAPCs). When differentiated endothelial-specific media, these...
After periods of microgravity or bed rest, individuals often exhibit reduced V̇o 2 max , hypovolemia, cardiac and vascular effects, autonomic dysfunction. Recently, alterations in expression central nervous system NO synthase (NOS) have been observed hindlimb-unloaded (HU) rats, a model used to simulate physiological effects rest. We examined the 14 days hindlimb unloading on hemodynamic responses systemic NOS inhibition conscious control HU rats. Because differences regulation might occur...