Purpose of the study: Investigating health disparities requires studies designed to recruit and retain racially socioeconomically diverse cohorts. It is critical address barriers that disproportionately affect participation in clinical research by minorities disadvantaged. This study sought identify rectify these a biracial (African American non-Hispanic White) cohort for longitudinal study. Design Method: The Healthy Aging Neighborhoods Diversity across Life Span 20-year examination how...

BackgroundPsoriasis is an immunodysregulatory inflammatory disease associated with comorbidities affecting quality of life. With the advent new treatments, there growing need to assess long-term safety and efficacy treatments in a real-world setting.ObjectiveThe objective Corrona Psoriasis Registry study comparative Food Drug Administration–approved biologic treatments.MethodsA cross-sectional patients enrolled registry, who initiated or switched systemic therapy at enrollment previous 12...

Objectives This analysis examined the association between psoriasis severity, assessed by body surface area (BSA) and Investigator’s Global Assessment (IGA; previously used only in clinical trials), patient-reported outcomes (PROs) a real-world setting. Design Cross-sectional within Corrona Psoriasis Registry, an independent, prospective registry. Setting 70 dermatology practices USA. Participants 1529 adult patients with being treated biological or non-biological systemic treatment 31 May...

Background Dietary antioxidants can inhibit reactions accompanying neurodegeneration and thus prevent cognitive impairment. We describe associations of dietary with function in a large biracial population, while testing moderation by sex, race, age mediation depressive symptoms. Methods This was cross-sectional analysis 1274 adults (541 men 733 women) aged 30 to 64 years at baseline (mean [standard deviation] = 47.5 [9.3]) the Healthy Aging Neighborhoods Diversity Across Lifespan Study,...

The primary objective of this cross-sectional study was to characterize dietary patterns African Americans and Whites, 30 64 years, examined in the Healthy Aging Neighborhoods Diversity across Life Span study. Other objectives were evaluate micronutrient adequacy each pattern determine association diet with sarcopenia. Cluster analysis used mean ratio (MAR) 15 micronutrients. Ten clusters identified: sandwich, sweet drink, pizza, poultry, frozen meal, dessert, alcoholic bread, starchy...

<b><i>Background:</i></b> Real-world studies evaluating patients with challenging-to-treat localizations of psoriasis (scalp, nail, and palmoplantar) are limited. <b><i>Objective:</i></b> To characterize versus without in areas seen routine US clinical practice. <b><i>Methods:</i></b> This retrospective observational study included all adult enrolled the Corrona Psoriasis Registry between April 2015 May 2018 who...

Large Language Models (LLMs) have enabled new ways to satisfy information needs.Although great strides been made in applying them settings like document ranking and short-form text generation, they still struggle compose complete, accurate, verifiable long-form reports.Reports with these qualities are necessary the complex, nuanced, or multi-faceted needs of users.In this perspective paper, we draw together opinions from industry academia, a variety related research areas, present our vision...

To assess the predictive values of various adiposity indices for metabolic syndrome (MetS) among adults using baseline data from Healthy Aging in Neighborhoods Diversity across Life Span (HANDLS) cohort.In a cross-sectional study, BMI, waist circumference (WC), body composition by dual-energy X-ray absorptiometry (DEXA) and risk factors such as TAG, HDL cholesterol, blood pressure, fasting glucose insulin, uric acid C-reactive protein were measured. Receiver-operating characteristic (ROC)...

Background: Recent research has linked caffeine consumption with a lower risk for depression and cognitive decline. However, no studies have examined the relationship in an African American compared to white, socioeconomically diverse representative urban sample. Methods: Data from cross-sectional study were used determine associations of use depressive symptomatology cognition sample 1,724 participants Healthy Aging Neighborhoods Diversity across Life Span (HANDLS) study. The United States...

Biologic therapies have dramatically changed the management of moderate to severe psoriasis; however, few US real-world studies characterize unmet needs patients who do not respond biologic therapies. This study examined characteristics at enrollment with psoriasis had insufficient responses anti-tumor necrosis factor (anti-TNFs).Patients enrolled in Corrona Psoriasis Registry from April 2015 June 2018 initiated an anti-TNF were stratified on basis body surface area (BSA) improvement <3% or...

Objective. Treatment options for psoriatic arthritis (PsA) have increased and improved in the past decade; treatment patterns PsA remain poorly understood. Understanding current practices would aid management of patients with PsA. Methods. This observational study was based on data from Corrona registry adult North America collected between January 1, 2004, December 31, 2012. Patients were divided among 3 therapy cohorts: tumor necrosis factor inhibitor (TNFi) monotherapy, methotrexate (MTX)...

High-energy-dense foods provide an inexpensive source of calories. Healthy Aging in Neighborhoods Diversity across the Life Span study participants (n = 1987), low- to low-middle-income, urban African American and white adults, consumed between 17% 20% their daily energy intake from beverages. Of all beverages consumed, calorically sweetened ranked second among Americans third whites. Calorically-sweetened beverage consumption was not influenced by weight status. Increasing awareness risks...

Literacy influences dietary outcomes, such as food label comprehension and portion size estimation skills. This study evaluated the relationship of literacy diet quality among Healthy Aging in Neighborhoods Diversity across Life Span participants. is a prospective socioeconomically diverse urban African Americans whites. Diet was measured by Eating Index-2010 on basis 2 recalls, literacy, Wide Range Achievement Test—3rd edition reading scores. An independent synergistic association education...

The goal of this study was to evaluate how frequently rheumatoid arthritis (RA) therapy is instituted promptly and describe the characteristics patients who are not treated early upon diagnosis.The percentage at time enrollment in Corrona registry were receiving any RA-directed evaluated their summarized. subsequent initiation also estimated.Among 35,485 enrolled Corrona, 34,735 (97.9%) on appropriate for RA 750 (2.1%) had no history enrollment. Among without therapy, overall disease...

Abstract Objective The present study examined the association of serum ferritin with CHD risk using Framingham Heart Study's 10-year algorithm. Design Ordinal logistic regression modelling was used to interpret risk. Proportional odds assessed four divisions ranked (4, high; 3, increased; 2, slight; 1, minimal), separately by sex. Setting Baltimore, MD, USA. Subjects African-American and white participants ( n 1823) from baseline Healthy Aging in Neighborhoods Diversity across Life Span...

Abstract Objective Analysing dietary data to capture how individuals typically consume foods is dependent on the coding variables used. Individual consumed simultaneously, like coffee with milk, are given codes identify these combinations. Our literature review revealed a lack of discussion about using combination in analysis. The present study identified at mealtimes and by race when were or not utilized. Design Duplicate analysis methods performed separate sets. original set consisted all...

Determine healthcare resource utilization (HCRU) in biologic-naïve initiators of TNF inhibitors (TNFis) associated with their disease activity from a national cohort rheumatoid arthritis (RA) patients.RA patients were identified at first TNFi initiation (index date) the Corrona registry. Patients age RA onset <18, comorbid psoriasis/psoriatic arthritis, fibromyalgia, or osteoarthritis excluded. categorized into (DA) strata by lowest level DA (and sustaining low levels for least two visits)...

Abstract Introduction The National Psoriasis Foundation ( NPF ) published treat‐to‐target guidelines for psoriasis, yet their applicability in clinical practice remains unknown. Objectives To estimate the proportion of psoriasis patients meeting 's body surface area BSA ‘target’ (≤1%) and ‘acceptable’ (≤3%) response criteria cross‐sectional associations these with patient‐reported outcomes PRO s) Corrona Registry. Methods Separately three independent cohorts at (i) enrolment, (ii) 6‐month...

Objective Biologic therapies have revolutionized the management of moderate-to-severe psoriasis; however, there are a limited number US real-world studies characterizing patients based on response to these treatments. This study examined characteristics at enrollment and change in outcomes with psoriasis who achieved insufficient responses ustekinumab.Methods included enrolled Corrona Psoriasis Registry from April 2015 June 2018 initiated ustekinumab were stratified achievement body surface...