A5023968177- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Biosimilars and Bioanalytical Methods
- Monoclonal and Polyclonal Antibodies Research
- Autoimmune and Inflammatory Disorders Research
- Pharmacogenetics and Drug Metabolism
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health Systems, Economic Evaluations, Quality of Life
- Peripheral Neuropathies and Disorders
- Chronic Disease Management Strategies
- Social Media in Health Education
- Telemedicine and Telehealth Implementation
- Healthcare Systems and Technology
- Pharmacovigilance and Adverse Drug Reactions
- COVID-19 and healthcare impacts
- Adolescent and Pediatric Healthcare
- Renal Diseases and Glomerulopathies
- Hepatitis C virus research
- Human Resource and Talent Management
- Sarcoidosis and Beryllium Toxicity Research
- Chronic Lymphocytic Leukemia Research
University of Alabama at Birmingham
2020-2024
The effect of the COVID-19 pandemic on community-based rheumatology care and use telehealth is unclear. We undertook this study to investigate impact delivery in a large community practice-based network.Using rheumatologist network, we examined trends in-person versus visits canceled 3 time periods: pre-COVID-19, transition (6 weeks beginning March 23, 2020), post-COVID-19 (May-August). In period, compared patients who received those cancelled all visits. used multivariable logistic...
Background Digital health studies using electronic patient-reported outcomes (ePROs) and wearables bring new challenges, including the need for participants to consistently provide trial data. Objective This study aims characterize engagement, protocol adherence, data completeness among with rheumatoid arthritis enrolled in Tracking of Arthritis Longitudinally (DIGITAL) study. Methods Participants were invited participate this app-based study, which included a 14-day run-in an 84-day main In...
In patients with rheumatoid arthritis (RA), attaining remission or low disease activity (LDA), as recommended by the treat-to-target approach, has shown to yield improvement in symptoms and quality of life. However, limited evidence from real-world settings is available support premise that better control associated lower healthcare costs. This study fills gaps regarding cost care RA (DA) states therapy.This retrospective cohort linked medical prescription claims Optum Clinformatics Data...
Abstract Background/purpose Interstitial lung disease (ILD) is an important problem for patients with rheumatoid arthritis (RA). However, current approaches to ILD case finding in real-world data have been evaluated only limited settings and identify prevalent not new-onset disease. Our objective was develop, refine, validate a claims-based algorithm both incident RA compared the gold standard of medical record review. Methods We used administrative claims 2006–2015 from Medicare derive...
Abstract Purpose We assessed the suitability of pooled electronic health record (EHR) data from clinical research networks (CRNs) patient‐centered outcomes network to conduct studies association between tumor necrosis factor inhibitors (TNFi) and infections. Methods EHR patients with one seven autoimmune diseases were obtained three CRNs pooled. Person‐level linkage CRN Centers for Medicare Medicaid Services (CMS) fee‐for‐service claims was performed where possible. Using filled...
Repository corticotropin injection (RCI, Acthar® Gel) is a naturally sourced mixture of adrenocorticotropic hormone analogues and other pituitary peptides with anti-inflammatory immunomodulatory effects. In recent clinical trial, RCI was safe effective for the treatment refractory rheumatoid arthritis (RA). This study aims to describe real-world use outcomes patients RA who were prescribed in practice through retrospective analysis an electronic medical record database.Patients identified...
BACKGROUND: Systemic lupus erythematosus (SLE) is a complex clinical diagnosis historically aided by imperfect biomarkers. The advent of multianalyte assay panel incorporating innovative cell-bound complement activation markers necessitates comparison its utility to conventional autoantibodies for the and treatment SLE. OBJECTIVES: To compare likelihood SLE diagnosis, initiation, downstream impact on health care utilization among patients tested with AVISE Lupus (AVISE) vs standard-of-care...
<h3>Background:</h3> Recruiting patients for research is one of the most challenging aspects a study. Researchers may employ plethora methods to recruit patients, including physician referrals, flyers, emails, patient portal messages, social media announcements and cold calls. <h3>Objectives:</h3> The objective this study was assess impact recruitment adapted by remote process conduct decentralized studies. We identified factors associated with successful efficient screening demographics...
Background: Patients with rheumatoid arthritis (RA) who have received multiple biologics or targeted therapies over time tend to more refractory and severe disease, which may lead worse clinical response treatment. Objectives: We used data from the ACR RISE registry assess whether disease severity was greater in those sarilumab shortly after its FDA approval (May 2017) than subsequent periods evaluate effectiveness of populations various degrees severity. Methods: RA initiated treatment...
Background: Clear characterization of how different types patient-generated data reflect patient experience is needed to guide integration electronic patient-reported outcome (ePRO) measures and biometrics in generating real-word evidence (RWE) related rheumatoid arthritis (RA). Objectives: To characterize the level participant (pt) engagement/adherence completeness an ongoing study 250 RA pts enrolled Digital Tracking Arthritis Longitudinally (DIGITAL) 1 ArthritisPower real-world registry....
<sec> <title>BACKGROUND</title> Digital health studies using electronic patient-reported outcomes (ePROs) and wearables bring new challenges, including the need for participants to consistently provide trial data. </sec> <title>OBJECTIVE</title> This study aims characterize engagement, protocol adherence, data completeness among with rheumatoid arthritis enrolled in Tracking of Arthritis Longitudinally (DIGITAL) study. <title>METHODS</title> Participants were invited participate this...
<h3>Background</h3> Systemic Lupus Erythematosus (SLE) is a complex clinical disease that often takes years and repeated testing to adequately diagnose. Standard biomarkers have low specificity (ANA) or sensitivity (anti-dsDNA, anti-Smith). The advent of multianalyte assay panel (MAP) incorporating innovative cell-bound complement activation markers warrants comparison its utility conventional autoantibodies for the diagnosis treatment SLE. <h3>Objective</h3> This study compares likelihood...