A5015318144- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Cell Image Analysis Techniques
- Molecular Biology Techniques and Applications
- Histone Deacetylase Inhibitors Research
- RNA modifications and cancer
- Environmental DNA in Biodiversity Studies
- Genomics and Phylogenetic Studies
- Freshwater macroinvertebrate diversity and ecology
- Carcinogens and Genotoxicity Assessment
- Autophagy in Disease and Therapy
- Peptidase Inhibition and Analysis
Research Institute in Oncology and Hematology
2024
CancerCare Manitoba
2021-2024
University of Manitoba
2019-2024
Abstract Proteolysis targeting chimeras (PROTAC) are an emerging precision medicine strategy, which targets key proteins for proteolytic degradation to ultimately induce cancer cell killing. These hetero-bifunctional molecules hijack the ubiquitin proteasome system selectively add polyubiquitin chains onto a specific protein target degradation. Importantly, PROTACs have capacity virtually any intracellular and transmembrane degradation, including oncoproteins previously considered...
The pale summer sedge caddisfly, Limnephilus hyalinus Hagen, 1861 (Limnephilidae, the Northern Caddisflies), is widespread in North America. Genome skimming by Illumina sequencing allowed assembly of a complete 15,168 bp circular mitogenome from L. consisting 78.0% AT nucleotides, 22 tRNAs, 13 protein-coding genes, two rRNAs and control region ancestral insect gene order. COX1 features an atypical CGA start codon while ATP8, NAD1, NAD5, NAD6 exhibit incomplete stop codons. mtTERM binding...