A5017908067- Mathematical Biology Tumor Growth
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Medical Imaging Techniques and Applications
- Computational Drug Discovery Methods
- Radiomics and Machine Learning in Medical Imaging
- Gene Regulatory Network Analysis
- Spectroscopy Techniques in Biomedical and Chemical Research
- Microfluidic and Capillary Electrophoresis Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Single-cell and spatial transcriptomics
- Advanced Fluorescence Microscopy Techniques
Buda Health Center
2022-2024
Obuda University
2022
Optimized therapies for the individual patient provide a more cost-effective, secure method of chemotherapy. Therapy optimization demands reliable mathematical model tumor growth, pharmacodynamics, and effect chemotherapeutic agent used during therapy. Examining these effects processes in vitro cell culture experiments maintain cheaper ethical to create growth pharmacodynamics models estimate their parameters. In this work, parameter identification was carried out by using cytotoxicity...
One of the promising directions in future medicine is optimization therapies based on mathematical and engi-neering methods, with which treatment can be personalized. In personalization, key issue identification model parameters. We carry out using artificial neural networks, require training. generate training data that as realistic possible, by generating sparse datasets. aim to simulate experimental setups also take presence holidays into account, when drug injection tumor volume...
With the advancement of technology and medicine, personalized therapies arise which may provide a promising solution for problems chemotherapy, such as many side effects. Personalized can be applied that meet individual needs patients, this make healthcare cancer patients safer more cost-effective. However, therapy requires reliable model tumor dynamics effect drug during therapy. Examining certain drugs on in vitro cell cultures helps us to gain understanding mechanism create...
Optimizing computer-generated therapy may be one of the most promising tools for future medical treatments. In silico experiments are crucial planning and testing, this requires a reliable virtual patient model. We present noise model that can used to real measurement from mice add experiments, measurements performed with digital caliper, tumor is measured through skin, which reason why significant nonlinear expected. use data preclinical estimate transformation whiten noise. Finally, we...
Fluorescent live cell imaging is a widely used method in studying vitro cultures, thus the behavior of tumor spheroids can be examined cheaply and simply over several days. However, during days lasting experiments with many measurement points, strong laser light that excites fluorescent sample have destructive effect on living cells. This phenomenon phototoxicity, consideration which fundamental importance such long-term cytotoxicity measurements, order to filter out those cell-damaging...