A5115599057- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Saffron Plant Research Studies
- Morinda citrifolia extract uses
- Medicinal Plants and Bioactive Compounds
- Cancer therapeutics and mechanisms
- Neurological Disease Mechanisms and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Metabolomics and Mass Spectrometry Studies
Xiangnan University
2023-2024
Two series of 1,4-naphthoquinone-chromone hybrids 4a (4aa–4ao) and 4b (4ba–4bq) were designed, synthesized evaluated as antitumor agents.
Ethnopharmacological relevance: Lonicerae japonicae flos (LJF) is a medicine and food homology that modulates inflammatory responses. LIF effective in treating acute lung injury by heat with cold based on the Miao medical theory of "cold treatment fever, disease heat" . Our preliminary study showed LJF can intervene injury(ALI) through IL-17 signaling pathway, but material basis still unclear.Aim study: So, it aim to investigate potential targets pharmacodynamic JLF anti-ALI serum...
Two series of 1,4-naphthoquinone-chromone hybrids 4a (4aa-4ao) and 4b (4ba-4bq), were designed, synthesized evaluated as antitumor agents. The most compounds exhibited moderate to excellent cytotoxicity tumor cells (K562 A549), especially the that showed equal or stronger antiproliferative activity compared positive control cisplatin on two different types (except for 4al 4an). Among them, compound 4ac significant inhibitory A549 with IC50 value 2.93 µM, which was 5.2 times more active than...