A5072121968- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Estrogen and related hormone effects
- Cancer-related molecular mechanisms research
- Inflammasome and immune disorders
- Circular RNAs in diseases
- Radiomics and Machine Learning in Medical Imaging
- Inflammatory mediators and NSAID effects
- MicroRNA in disease regulation
- Head and Neck Anomalies
- Chemical Synthesis and Analysis
- Autophagy in Disease and Therapy
- Biomarkers in Disease Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer, Lipids, and Metabolism
- Tryptophan and brain disorders
- Breast Lesions and Carcinomas
- Ovarian cancer diagnosis and treatment
- AI in cancer detection
- Parathyroid Disorders and Treatments
- Tracheal and airway disorders
- RNA modifications and cancer
- RNA Research and Splicing
- S100 Proteins and Annexins
- Glutathione Transferases and Polymorphisms
Ningbo Medical Center Lihuili Hospital
2019-2024
Zhejiang Chinese Medical University
2023
Jilin University
2013-2014
First Hospital of Jilin University
2013-2014
Abstract Anaplastic thyroid cancer (ATC) is among the most aggressive and metastatic malignancies, often resulting in fatal outcomes due to lack of effective treatments. Prosapogenin A (PA), a bioactive compound prevalent traditional Chinese herbs, has shown potential as an antineoplastic agent against various human tumors. However, its effects on ATC underlying mechanism remain unclear. Here, we demonstrate that PA exhibits significant anti-ATC activity both vitro vivo by inducing...
The aim of the present study was to investigate antitumor effect celecoxib (CXB) combined with doxorubicin (DOX) on subcutaneous xenograft tumor medullary thyroid carcinoma in nude mice, and analyze possible mechanism action. Nude mice xenografted (MTC) were randomly divided into control, CXB, DOX plus CXB groups, drug treatment administered for three weeks. It found that inhibition rates apoptosis index groups higher than control group (P<0.01), these values combination compared single‑drug...
A growing body of evidence indicates that aberrant expression miR-107 plays a core role in cancers. This study aims to demonstrate the function and its roles chemo-drug resistance breast cancer cells.CCK-8 assays were carried out test effect mimics on proliferation MCF-7 cells. The apoptosis level each group was detected by flow cytometry. level, mRNA levels Bcl-2/Bax TRIAP1 quantitative real-time Polymerase Chain Reaction (qRT-PCR) analysis. Protein Bcl-2/Bax, p-Akt/Akt cells using Western...
Papillary thyroid carcinoma (PTC) is the most common type of cancer, and surgery crucial for curing PTC. PTC patients often experience lymph node metastasis (LNM) in neck, central (CLNM) significantly affects recurrence rate Therefore, thoroughness particularly important treatment However, there still controversy regarding choice surgical approach. This study retrospectively analyzed clinical data 69 treated at our hospital from December 2019 to April 2022 clinically high-risk factors neck...
Abstract Little work has been done on the prediction of malignancy risk in patients with subcentimeter thyroid nodule (TN) categorized as atypia/follicular lesion undetermined significance (AUS/FLUS). We performed a retrospective analysis medical records TNs whose initial fine-needle aspiration (FNA) diagnosis was AUS/FLUS at our center between November 2013 and August 2018. Univariate multivariate logistic regression were used to select independent factors associated malignancy. Of 324 who...
Plasmacytoma variant translocation 1 circular RNA (circPVT1) is involved in the initiation and development of several types cancer. However, underlying molecular role circPVT1 tumorigenesis thyroid cancer remains to be elucidated. In present study, relative expression was markedly upregulated compared with adjacent normal tissue. associated clinical stage lymph node metastasis. Furthermore, Cell Counting Kit-8, colony formation Transwell chamber assays demonstrated that knockdown decreased...
The purpose of this study was to investigate the mechanisms antitumor effect celecoxib (CXB) in treatment human medullary thyroid carcinoma (MTC). Human MTC TT cells were cultured with different concentrations (0, 20, 40, 60 µmol/l) CXB following 0-72 h vitro. An MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay used determine growth inhibition Flow cytometry performed analyze cell cycle cells. Levels prostaglandin E2 (PGE2) measured by enzyme-linked immunosorbent...
Papillary thyroid carcinoma (PTC) and papillary microcarcinoma (PTMC) are generally characterized as less invasive forms of cancer with favorable prognosis. However, once lateral cervical lymph node metastasis takes place, the prognosis may be significantly impacted. The purpose this study was to evaluate whether there is a difference in pattern between PTC PTMC. A retrospective analysis performed for PTMC patients that underwent central area dissection unilateral neck (II-V area) January...
Objective: To develop a clinical-radiomics model using multimodal machine learning method for distinguishing ductal carcinoma in situ (DCIS) from breast fibromatosis. Methods: The clinical factors, ultrasound features, and related images of 306 patients (198 DCIS patients) were retrospectively collected. Patients the development validation cohort 184 122, respectively. independent factors identified by multivariable logistic regression analysis used clinical-ultrasound construction. Then,...
The incidence of papillary thyroid cancer (PTC) has been increasing annually; however, early diagnosis can improve patient outcomes. Pyroptosis is a programmed cell death modality that received considerable attention recently. However, no studies have reported using pyroptosis-related genes in PTC diagnosis.
Long non-coding RNA Down syndrome cell adhesion molecule-antisense 1 (DSCAM-AS1) has been reported to play key roles in the progression and initiation of several cancer types. However, various functional DSCAM-AS1 thyroid tumorigenesis remain largely elusive. In present study, expression was examined tissues lines. Cell Counting Kit-8, wound healing, Transwell clonogenic assays were conducted detect proliferation, migration, invasion colony formation, respectively. The association with...
Objective To observe the inhibitory effect of celecoxib on growth transplant tumor medullary thyroid carcinoma in nude mice.Methods Forty mice were randomly divided into 4 groups (A,B,C and D):control group,celecoxib group,doxorubicin group ± doxorubicin group.All vaccination animal models established by subcutaneous injection 2 × 106 human TT cells.The was given 300 mg/(kg·d),and mg/(kg·d).Tumor volumes weight measured one week after administration when 0.5 cm nodus appeared region,and...
Objective This paper aimed to evaluate the clinical value of performing an endoscopic total parathyroidectomy through anterior chest approach with autotransplantation (EACtPTx+AT) in treating secondary hyperparathyroidism (SHPT) summarize and share experience. Methods 24 patients SHPT were retrospectively analyzed:11 underwent open (OtPTx+AT Group) 13 (EACtPTx+AT Group). Comparing two groups regarding following factors: (1) operating conditions, such as blood loss during operation, length...