A5040011843- Nitric Oxide and Endothelin Effects
- Eicosanoids and Hypertension Pharmacology
- Inflammatory mediators and NSAID effects
- Cardiac Imaging and Diagnostics
- Hormonal Regulation and Hypertension
Shantou University Medical College
2022-2024
Shantou University
2022-2024
BACKGROUND: Prostaglandin I 2 synthesized by endothelial COX (cyclooxygenase) evokes potent vasodilation in some blood vessels but is paradoxically responsible for endothelium-dependent constriction (EDC) others. production and EDC may be enhanced diseases such as hypertension. However, how PGIS (prostaglandin synthase) deficiency affects this implicated the consequent cardiovascular pathologies remain largely unknown. METHODS: Experiments were performed with wild-type, Pgis knockout ( − / )...
The F prostanoid receptor (FP), which accounts for the therapeutic effect of PGF2α in uterine atony that leads to postpartum hemorrhage and maternal morbidity, could possibly mediate vasoconstrictor small or resistance arteries elevate blood pressure limits clinical use agent patients with cardiovascular disorders. This study aimed test above hypothesis genetically altered mice. Ex vivo experiments were performed on control wild-type (WT) mice deficiencies FP (FP-/- ) thromboxane...
Introduction: Abnormalities in prostacyclin synthase (PGIS) cause hypertension and/or renal pathologies humans and mice due to increased thromboxane A2 (TxA 2 ) produced by platelets kidneys. However, the kidney, which is key organ blood pressure regulation, mainly produces prostaglandin E2 (PGE ), could evoke vasoconstriction via activating E prostanoid receptor-3 (EP3) Tx receptor (TP; of TxA ). We hypothesized that PGE kidney contributes above-mentioned disorders EP3 receptor. Methods: To...