A5101486992- Eicosanoids and Hypertension Pharmacology
- Inflammatory mediators and NSAID effects
- Nitric Oxide and Endothelin Effects
- Hormonal Regulation and Hypertension
- Spinal Fractures and Fixation Techniques
- Pain Mechanisms and Treatments
- Quantum Chromodynamics and Particle Interactions
- Particle physics theoretical and experimental studies
- Spine and Intervertebral Disc Pathology
- Intraocular Surgery and Lenses
- Elbow and Forearm Trauma Treatment
- Pelvic and Acetabular Injuries
- Traditional Chinese Medicine Analysis
- Traditional Chinese Medicine Studies
- High-Energy Particle Collisions Research
- Hip and Femur Fractures
- Pain Management and Opioid Use
- Air Quality and Health Impacts
- Estrogen and related hormone effects
- Orthopedic Surgery and Rehabilitation
- Advanced Glycation End Products research
- Biosensors and Analytical Detection
- Plant and Biological Electrophysiology Studies
- Blood transfusion and management
- Chromium effects and bioremediation
Tianjin Medical University General Hospital
2018-2025
Institute of Hematology & Blood Diseases Hospital
2025
Wuhan University
2024
Shantou University
2015-2024
Shantou University Medical College
2015-2024
Inner Mongolia Medical University
2018-2024
Hainan Medical University
2024
Zhuhai People's Hospital
2024
Harrison International Peace Hospital
2023
Shenzhen Maternity and Child Healthcare Hospital
2023
Abstract PM2.5 derived from automobile exhaust can cause reproductive impairment in adult males, but the toxic effects of exposure on function juvenile male rats and its relationship with ferroptosis have not been reported. In this paper, 30-day-old Sprague-Dawley (SD) were divided into four groups (blank control, vitamin PM2.5, PM2.5+Vitamin). The blank control group was fed normally, given intragastric administration vitamins addition to normal feeding. administered via tracheal...
This study tested the hypothesis that in diabetic arteries, cyclooxygenase (COX)-1 mediates endothelial prostacyclin (PGI 2 ) synthesis, which evokes vasoconstrictor activity under pathological condition. Non-insulin-dependent diabetes was induced to C57BL/6 mice and those with COX-1 deficiency (COX-1 −/− mice) using a high-fat diet combination streptozotocin injection. In vitro analyses were performed 3 mo after. Results showed aortas, muscarinic receptor agonist ACh evoked an...
Prostacyclin, also termed as prostaglandin I2 (PGI2), evokes contraction in vessels with limited expression of the prostacyclin receptor. Although thromboxane-prostanoid receptor (TP) is proposed to mediate such a response PGI2, other unknown receptor(s) might be involved. TP knockout (TP-/-) mice were thus designed and used test hypothesis. Vessels, which normally show isolated for functional biochemical analyses. Here, we showed that contractile evoked by PGI2 was indeed only partially...
The objective of this study was to determine the role cyclooxygenase (COX)-1 or -2 in endothelium-dependent contraction under atherosclerotic conditions. Atherosclerosis induced apoE knockout (apoE(-/-)) mice and those with COX-1(-/-) (apoE(-/-)-COX-1(-/-)) by feeding high fat cholesterol food. Aortas (abdominal whole section) were isolated for functional and/or biochemical analyses. As non-atherosclerotic conditions, muscarinic receptor agonist acetylcholine (ACh) evoked an...
Abstract Aims Cardiovascular side effects caused by non-steroidal anti-inflammatory drugs (NSAIDs), which all inhibit cyclooxygenase (COX)-2, have prevented development of new that target prostaglandins to treat inflammation and cancer. Microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors efficacy in the NSAID arena but their cardiovascular safety is not known. Our previous work identified asymmetric dimethylarginine (ADMA), an inhibitor endothelial nitric oxide synthase, as a...
This study aimed to determine whether prostacyclin (PGI2) functions as an endothelium-derived contracting factor (EDCF) in young rat renal arteries, and, if so, we wanted examine the underlying mechanism(s) and how it changes prehypertensive conditions. Vessels from Wistar-Kyoto (WKY) spontaneously hypertensive rats (SHRs) of 25-28 days age were isolated for functional biochemical analyses. Result showed that following NO synthase (NOS) inhibition PGI2 thromboxane-prostanoid (TP) receptor...
This study aimed to determine whether E prostanoid receptor-3 (EP3) is involved in prostacyclin (PGI2)-evoked vasoconstrictor activity of resistance arteries and if so, how it changes under hypertensive conditions. Mesenteric from Wistar-Kyoto rats (WKYs) spontaneously (SHRs) were isolated for functional biochemical studies. Here we show that vessels WKYs, PGI2 or the endothelial muscarinic agonist ACh (which stimulates vitro synthesis) evoked activity, which increased SHRs. The...
The vasoconstrictor and/or pressor effects of prostaglandin (PG)F2α participate in the development vascular pathologies and limit clinical use agent. This study aimed to determine receptor types responsible for activity PGF2α whether they mediate response evoked by prostanoid under vivo conditions. Experiments were performed on genetically altered mice vessels from these or humans. Here we show that deletion thromboxane-prostanoid (TP−/−) abolished drastically diminished contraction isolated...
Abstract Although commonly thought to produce prostacyclin (prostaglandin I 2 ; PGI ) that evokes vasodilatation and protects vessels from the development of diseases, endothelial cyclooxygenase (COX)‐mediated metabolism has also been found release substance(s) called endothelium‐derived contracting factor(s) (EDCF) causes endothelium‐dependent contraction implicates in dysfunction disease conditions. Various mechanisms have proposed for process; however, major COX metabolite , which...
BACKGROUND: Prostaglandin I 2 synthesized by endothelial COX (cyclooxygenase) evokes potent vasodilation in some blood vessels but is paradoxically responsible for endothelium-dependent constriction (EDC) others. production and EDC may be enhanced diseases such as hypertension. However, how PGIS (prostaglandin synthase) deficiency affects this implicated the consequent cardiovascular pathologies remain largely unknown. METHODS: Experiments were performed with wild-type, Pgis knockout ( − / )...
This study tested the hypothesis that in hypertensive arteries cyclooxygenase-1 (COX-1) remains as a major form, mediating prostacyclin (prostaglandin I2; PGI2) synthesis may evoke vasoconstrictor response presence of functional vasodilator PGI2 (IP) receptors. Two-kidney-one-clip (2K1C) hypertension was induced wild-type (WT) mice and/or those with COX-1 deficiency (COX-1-/-). Carotid were isolated for analyses 4 weeks after. Results showed normotensive mice, muscarinic receptor agonist ACh...
Prostacyclin is a fundamental signaling pathway traditionally associated with the cardiovascular system and protection against thrombosis but which also has regulatory functions in fibrosis, proliferation, immunity. Prevailing dogma states that prostacyclin principally derived from vascular endothelium, although it known other cells can synthesize it. However, role of nonendothelial sources production not been systematically evaluated resulting an underappreciation their importance relative...
Although recognized to have an in vivo vasodepressor effect blunted by the vasoconstrictor of E-prostanoid receptor-3 (EP3), prostaglandin E2 (PGE2 ) evokes contractions many vascular beds that are sensitive antagonizing thromboxane prostanoid receptor (TP). This study aimed determine direct PGE2 on renal arteries and/or whole vasculature and how each these two receptors is involved responses. Experiments were performed isolated vessels perfused kidneys wild-type mice with deficiency TP...
Vasomotor reactions of prostacyclin (prostaglandin I2 ; PGI2 ) can be collectively modulated by thromboxane prostanoid receptor (TP), E-prostanoid receptor-3 (EP3), and the vasodilator I (IP). This study aimed to determine direct effect on renal arteries and/or whole vasculature how each these receptors is involved. Experiments were performed vessels or perfused kidneys wild-type mice with deficiency in TP (TP-/- EP3. Here we show that did not evoke relaxation, but instead resulted...