A5086198539- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- High-Temperature Coating Behaviors
- Advanced Proteomics Techniques and Applications
- Glass properties and applications
- Tuberculosis Research and Epidemiology
- Mitochondrial Function and Pathology
- Ubiquitin and proteasome pathways
- Metabolomics and Mass Spectrometry Studies
- Bioinformatics and Genomic Networks
- High Entropy Alloys Studies
- Cancer therapeutics and mechanisms
- Metallic Glasses and Amorphous Alloys
- High Temperature Alloys and Creep
- Biochemical and Molecular Research
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
University of Oxford
2024
Jiangsu University of Science and Technology
2021-2023
Fructose-1,6-bisphosphate (FBP), a cellular endogenous sugar metabolite in the glycolytic pathway, has recently been reported to act as signaling molecule regulate various events through engagement of important proteins. Though tremendous progress made identifying specific FBP–protein interactions, comprehensive identification FBP-interacting proteins and their regulatory mechanisms remains largely unexplored. Here, we describe concise synthetic approach for scalable preparation...
Abstract Tuberculosis remains a large global disease burden for which treatment regimens are protracted and monitoring of activity difficult. Existing detection methods rely almost exclusively on bacterial culture from sputum limits sampling to organisms the pulmonary surface. Advances in tuberculous lesions have utilized common glucoside [ 18 F]FDG, yet lack specificity causative pathogen Mycobacterium tuberculosis ( Mtb ) so do not directly correlate with viability. Here we show that close...
Deep understanding of sugar metabolite-protein interactions should provide implications on metabolic reprogramming in human physiopathology. Although tremendous efforts have been made for determining individual event, global profiling such interactome remains challenging. Here we describe thermal proteome glycolytic metabolite fructose-1,6-bisphosphate (FBP)-interacting proteins. Our results reveal a chemical signaling role FBP which acts as phosphate donor to activate phosphoglycerate...