A5101873841- Studies on Chitinases and Chitosanases
- Peptidase Inhibition and Analysis
- Galectins and Cancer Biology
- Protein Hydrolysis and Bioactive Peptides
- Autoimmune and Inflammatory Disorders
- Microscopic Colitis
- Angiogenesis and VEGF in Cancer
- Gut microbiota and health
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Invertebrate Immune Response Mechanisms
- Inflammatory Bowel Disease
- Metabolism and Genetic Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Microstructure and Mechanical Properties of Steels
- RNA Research and Splicing
- Cell death mechanisms and regulation
- Salivary Gland Disorders and Functions
- Tryptophan and brain disorders
- Monoclonal and Polyclonal Antibodies Research
- Retinoids in leukemia and cellular processes
- Virology and Viral Diseases
- Cancer Cells and Metastasis
- Circular RNAs in diseases
- Metal Forming Simulation Techniques
Affiliated Hospital of Youjiang Medical University for Nationalities
2024
China Pharmaceutical University
2022-2023
Shougang Institute of Technology
2022
China Iron and Steel Research Institute Group
2022
University of Massachusetts Amherst
2008-2020
Shanghai Jiao Tong University
2018-2020
XinHua Hospital
2018-2019
State of Illinois
2019
Pioneer (United States)
2008-2012
Baystate Medical Center
2008
Glioblastoma is one of the most fatal cancers, characterized by a strong vascularized phenotype. YKL-40, secreted glycoprotein, overexpressed in patients with glioblastomas and has potential as novel tumor biomarker. The molecular mechanisms YKL-40 glioblastoma development, however, are poorly understood. Here, we aimed to elucidate role plays regulation VEGF expression, angiogenesis, radioresistance. up-regulated expression cell line U87, both synergistically promote endothelial...
Abstract Backgrounds Long non-coding RNAs (lncRNAs) are essential factors that regulate tumor development and metastasis via diverse molecular mechanisms in a broad type of cancers. However, the pathological roles lncRNAs gallbladder carcinoma (GBC) remain largely unknown. Here we discovered novel lncRNA termed Highly expressed GBC (lncRNA-HGBC) which was upregulated tissue aimed to investigate its role regulatory mechanism progression GBC. Methods The expression level lncRNA-HGBC different...
Accumulating evidence has indicated that expression levels of YKL-40, a secreted glycoprotein, were elevated in multiple advanced human cancers. Recently, we have identified an angiogenic role YKL-40 cancer development. However, blockade the function which implicates therapeutic value, not been explored yet. Our current study sought to establish monoclonal anti-YKL-40 antibody as neutralizing for purpose blocking tumor angiogenesis and metastasis. A mouse (mAY) exhibited specific binding...
A secreted glycoprotein YKL-40 also named chitinase-3-like-1 is normally expressed by multiple cell types such as macrophages, chondrocytes, and vascular smooth muscle cells. However, a prominently high level of was found in wide spectrum human diseases including cancers chronic inflammatory where it strongly cancerous cells infiltrating macrophages. Here, we summarized recent important findings derived from during tumor angiogenesis development. potent angiogenic factor capable stimulating...
Chemo/radiotherapies are the most common adjuvant modality treated for patients with glioblastoma (GBM) following surgery. However, overall therapeutic benefits still uncertain, as mortality remains high. Elevated expression of YKL-40 in GBM was correlated increases mural cell-associated vessel coverage, stability and density, decreases permeability disease survival. To explore potential role cell-mediated tumor vascularization, we employed an anti-YKL-40 neutralizing antibody (mAY) ionizing...
Abstract Introduction Gut microbiota dysbiosis is a key factor of the pathogenesis post‐stroke depression (PSD). PSD associated with increased hippocampal neuronal apoptosis and decreased synaptic connectivity. Inulin can be involved in neuron protection through microbiome–gut–brain axis. However, neuroprotective effects inulin are still to further investigated. Methods By utilizing GEO public database, we identify differentially expressed genes hippocampus following intake. This help us...
The term programmed cell death (PCD) was coined in 1965 to describe the loss of intersegmental muscles (ISMs) moths at end metamorphosis. While it subsequently demonstrated that this hormonally controlled requires de novo gene expression, signal transduction pathway couples hormone action is largely unknown. Using ISMs from tobacco hawkmoth Manduca sexta, we have found Acheron/LARP6 mRNA induced ∼1,000-fold on day become committed die. Acheron functions as a survival protein protects cells...
Herein, the effect of heat treatment with die quenching on Zn‐coated hot stamping steel is analyzed. Heating temperatures are 850, 880, 900, and 930 °C, soaking times 4 8 min. Then, microstructure, hardness, coating layer morphology, element diffusion distribution, formation microcrack microvoid, oxidation Results reveal that as heating temperature increases, Vickers hardness increases when time min, while it decreases The least average value still larger than 460, resulting from martensitic...
Abstract Recent studies have shown that YKL-40, a secreted glycoprotein, is highly expressed in patients with advanced cancers including breast cancer, colorectal ovarian lung and brain tumors. We identified YKL-40 as an angiogenic molecule capable of stimulating endothelial cells different types cancers. Nevertheless, the therapeutic value targeting human remains unknown. Therefore, it was goal this study to develop monoclonal antibody against could bind specifically inhibit function regard...
Abstract Glioblastomas (GBM) are extremely aggressive and have the poorest prognosis among brain tumors. These tumors display extensive microvasculature that presumably originates from endothelial cell angiogenesis. Indeed, many anti-angiogenic therapies been accepted for glioblastoma treatment based on this premise. Recent evidence has shown stem-like cells (GSCs) can differentiate into participate in angiogenesis (Ricci-Vitiani L et al., Nature 2010;468:824-29, Wang 2010;468:829-33, &...
The inactivation of the cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor p16INK4A may be caused by gene deletion, mutation or promoter hypermethylation. We have previously reported that in hepatocellular carcinoma (HCC) tissues cell lines is inactivated predominantly hypermethylation rather than genomic aberrations. In present experiments, we studied effects demethylating agent, 5-aza-2′-deoxycytidine (5-AZA/decitabine), on expression aberrant RNA transcripts CDK–retinoblastoma pathway HCC...