A5041141841- Alzheimer's disease research and treatments
- Epigenetics and DNA Methylation
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Histone Deacetylase Inhibitors Research
- Tryptophan and brain disorders
- Bioinformatics and Genomic Networks
- Gut microbiota and health
- RNA modifications and cancer
- Immune cells in cancer
- Cerebrovascular and genetic disorders
- Plant Reproductive Biology
- Nuts composition and effects
- Gene expression and cancer classification
- Protein Tyrosine Phosphatases
- Ginkgo biloba and Cashew Applications
- Ferroptosis and cancer prognosis
- Atherosclerosis and Cardiovascular Diseases
- Plant Gene Expression Analysis
- GABA and Rice Research
- Orthopedic Infections and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Coconut Research and Applications
- RNA regulation and disease
- Medicinal Plants and Bioactive Compounds
Affiliated Hospital of Youjiang Medical University for Nationalities
2019-2024
Huanggang Normal University
2022
Yangtze University
2012-2013
Neuronal death is one of the key pathologies in Alzheimer's disease (AD). How neuronal begins AD far from clear, so clarifying this process may help develop effective therapies. This study collected single-cell RNA sequencing data 85 samples and 83 control samples, covering prefrontal cortex, internal olfactory superior parietal lobe, frontal gyrus, caudal somatosensory hippocampus, cortex peripheral blood mononuclear cells. Additionally, spatial transcriptomic coronal sections 6 AppNL-G-F...
Our previous studies revealed RBM8A may play a role in various progressive neurological diseases. The present study aimed to explore the of Alzheimer's disease (AD). is significantly down-regulated AD. Interestingly, 9186 differentially expressed genes are overlapped from comparisons AD versus control and RBM8A-low RBM8A-high. Weight gene correlation analysis was performed 9 functional modules were identified. Modules positively correlated with involved RAP1 signaling pathway, PI3K-AKT...
Despite tremendous progress in diagnosis and prediction of Alzheimer's disease (AD), the absence treatments implies need for further research. In this study, we screened AD biomarkers by comparing expression profiles control tissue samples used various models to identify potential biomarkers. We explored immune cells associated with these that are involved brain microenvironment.By differential analysis, identified differentially expressed genes (DEGs) four datasets (GSE125583, GSE118553,...
Phenylalanine ammonia-lyase (PAL) is the first key enzyme of phenypropanoid pathway. A full-length cDNA PAL gene was isolated from Juglans regia for time, and designated as JrPAL. The JrPAL contained a 1935bp open reading frame encoding 645-amino-acid protein with calculated molecular weight about 70.4 kD isoelectric point (pI) 6.7. deduced showed high identities other plant PALs. Molecular modeling that 3D model similar to Petroselinum crispum (PcPAL), implying may have functions PcPAL....
Vascular dementia (VD) and Alzheimer's disease (AD) are common types of for which no curative therapies known. In this study, we identified hub genes associated with AD VD in order to explore new potential therapeutic targets. Genes differentially expressed all three datasets (GSE122063, GSE132903, GSE5281) were used construct a protein-protein interaction network. We 10 modules containing 427 module VD. Module showing an area under the diagnostic curve > 0.60 or least absolute shrinkage...
Abstract Introduction Gut microbiota dysbiosis is a key factor of the pathogenesis post‐stroke depression (PSD). PSD associated with increased hippocampal neuronal apoptosis and decreased synaptic connectivity. Inulin can be involved in neuron protection through microbiome–gut–brain axis. However, neuroprotective effects inulin are still to further investigated. Methods By utilizing GEO public database, we identify differentially expressed genes hippocampus following intake. This help us...
Carotid atherosclerosis is a kind of systemic in the carotid arteries. However, efficiency treatment insufficient. Therefore, it urgent to find therapeutic targets and deepen understanding atherosclerosis.In this study, we analyzed differentially expressed genes (DEGs) between atheroma plaque macroscopically intact tissue (control samples). Furthermore, performed Gene Ontology (GO) Kyoto Encyclopedia Genomes (KEGG) enrichment analysis based on DEGs. Four methods were used identify hub...
Alzheimer's disease (AD) and sleep disorders are both neurodegenerative conditions characterized by impaired or absent sleep. However, potential common pathogenetic mechanisms of these diseases not well characterized.Differentially expressed genes (DEGs) were identified using publicly available human gene expression profiles GSE5281 for AD GSE40562 disorder. DEGs to the two datasets used enrichment analysis, we performed multi-scale embedded co-expression network analysis (MEGENA) DEGs. Fast...
To evaluate and identify the effects explore mechanisms of pyruvate kinase M2 (PKM2) on stroke-induced post stroke depression (PSD).Rats were separated into six different groups, including sham + saline, Stroke PSD recombinant (rPKM2) (112 ng/kg), rPKM2 (224 ng/kg) bevacizumab. Then, body weight, sucrose preference rate, immobility time, horizontal movement, vertical movement determined to effect PKM2 improving depressive behavior rats. Subsequently, proliferation oligodendrocytes in...
Background Cerebral small vessel disease (CSVD) is associated with the pathogenesis of Alzheimer’s (AD). Effective treatments to alleviate AD are still not currently available. Hence, we explored markers and underlying molecular mechanisms by utilizing gene expression profiles CSVD patients from public databases, providing more options for early diagnosis its treatment. Methods Gene were collected GSE63060 (for AD) GSE162790 CSVD). Differential analysis was performed between mild cognitive...
Alzheimer's disease (AD) is a progressive neurodegenerative that ranks as the fourth most common cause of death in developed countries.In our study, genes differentially expressed between AD and healthy individuals were identified used to construct protein-protein interaction (PPI) networks.The AD-related PPI network was identify functional modules, enrichment analysis showed they significantly involved "Alzheimer's disease", "apoptosis", related pathways.We predicted non-coding RNAs...
Ginkgolides are key pharmaceutical components in Ginkgo biloba leaves.1-Deoxy-D-xylulose-5-phosphate synthase (GbDXS) and geranylgeranyl pyrophosphate (GbGGPPS) genes critical involved ginkgolide biosynthesis.In this study, the promoters of GbDXS GGPPS, with 676 570 bp length, respectively, were cloned by chromosome walking.The cis-elements GbGGPPS predicted analyzed plant cis-acting regulatory element (CARE) database.We found some major sequence promoters.The promoter has 3 TATA boxes, 10...
Post-stroke depression (PSD) is a common cerebrovascular complication characterized by complex pathogenesis and poor treatment effects. Here, we tested the influence of differentially expressed genes (DEGs), non-targeted metabolites, intestinal microbes on occurrence development PSD. We acquired gene expression profiles for stroke patients, healthy controls from Gene Expression Omnibus database. After screening DEGs using differential analysis, identified in patients that were considered to...
Abstract In Alzheimer’s disease (AD), neuronal death is one of the key pathology. However, initiation in AD far from clear, and new targets are urgently needed to develop effective therapeutic methods. This study analyzed sequencing data single-cell RNAseq spatialomics, revealed impact global mapping cell spatial distribution relationships early stage AD. We found that microglia subpopulation Mic_PTPRG can anchor neurons based on ligand-receptor interaction pairs cause ectopic expression...
Post-stroke depression (PSD) is one of the most familiar complications stroke, which refers to stroke patients who have varying degrees (lasts for >2 weeks). SET domain-containing 3 (SETD3) a conserved histone H3 methyltransferase, and role SETD3 in some diseases increasingly being explored. However, effects PSD remain unclear. In this study, rat model was firstly constructed by Endothelin-1 injection combined with chronic unpredictable mild stress, we discovered that expression up-regulated...
The purpose of this study was to investigate the potential pathogenic mechanisms post-intracerebral hemorrhage depression.Profiles gene expression in brain tissue patients with intracerebral (ICH) or depression were downloaded from Gene Expression Omnibus (GEO) database. We analyzed differentially expressed genes (DEGs) for two diseases separately. With these DEGs, we conducted an enrichment analysis based on Ontology (GO) and Kyoto Encyclopedia Genes Genomes (KEGG) as well cross-talk...
Pueraria lobata (wild.) Ohwi is a leguminous plant and one of the traditional Chinese herbal medicines. Its puerarin extract widely used in pharmaceutical industry. This study reported chromosome-level genome assembly for P. its characteristics. The size was ~939.2 Mb, with contig N50 29.51 Mbp. Approximately 97.82% assembled sequences were represented by 11 pseudochromosomes. We identified that repetitive accounted 63.50% genome. A total 33,171 coding genes predicted, which 97.34% could...