A5080311029- Alzheimer's disease research and treatments
- Epigenetics and DNA Methylation
- Neurological Disease Mechanisms and Treatments
- RNA modifications and cancer
- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- RNA regulation and disease
- Cerebrovascular and genetic disorders
- Nuclear Receptors and Signaling
- Single-cell and spatial transcriptomics
- Glioma Diagnosis and Treatment
- Medicinal Plants and Bioactive Compounds
- Pharmacological Effects of Natural Compounds
- Brain Metastases and Treatment
- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
Guangxi Medical University
2022-2024
Neuronal death is one of the key pathologies in Alzheimer's disease (AD). How neuronal begins AD far from clear, so clarifying this process may help develop effective therapies. This study collected single-cell RNA sequencing data 85 samples and 83 control samples, covering prefrontal cortex, internal olfactory superior parietal lobe, frontal gyrus, caudal somatosensory hippocampus, cortex peripheral blood mononuclear cells. Additionally, spatial transcriptomic coronal sections 6 AppNL-G-F...
Despite tremendous progress in diagnosis and prediction of Alzheimer's disease (AD), the absence treatments implies need for further research. In this study, we screened AD biomarkers by comparing expression profiles control tissue samples used various models to identify potential biomarkers. We explored immune cells associated with these that are involved brain microenvironment.By differential analysis, identified differentially expressed genes (DEGs) four datasets (GSE125583, GSE118553,...
Mounting evidence supports the role of neuroinflammation in radiation-induced brain injury (RIBI), a chronic disease characterized by delayed and progressive neurological impairment. Asparagine endopeptidase (AEP), also known as legumain (LGMN), participates multiple malignancies neurodegenerative diseases may potentially be involved RIBI. Here, we found AEP expression was substantially elevated cortex hippocampus wild-type (
Vascular dementia (VD) and Alzheimer's disease (AD) are common types of for which no curative therapies known. In this study, we identified hub genes associated with AD VD in order to explore new potential therapeutic targets. Genes differentially expressed all three datasets (GSE122063, GSE132903, GSE5281) were used construct a protein-protein interaction network. We 10 modules containing 427 module VD. Module showing an area under the diagnostic curve > 0.60 or least absolute shrinkage...
Alzheimer's disease (AD) and sleep disorders are both neurodegenerative conditions characterized by impaired or absent sleep. However, potential common pathogenetic mechanisms of these diseases not well characterized.Differentially expressed genes (DEGs) were identified using publicly available human gene expression profiles GSE5281 for AD GSE40562 disorder. DEGs to the two datasets used enrichment analysis, we performed multi-scale embedded co-expression network analysis (MEGENA) DEGs. Fast...
Abstract Background Alzheimer’s disease (AD) is a complicated neurodegenerative disease. Neuron-glial cell interactions are an important but not fully understood process in the progression of AD. We used bioinformatic methods to analyze single-nucleus RNA sequencing (snRNA-seq) data investigate cellular and molecular biological processes Method snRNA-seq were downloaded from Gene Expression Omnibus (GEO) datasets reprocessed identify 240,804 single nuclei healthy controls patients with The...
Background Cerebral small vessel disease (CSVD) is associated with the pathogenesis of Alzheimer’s (AD). Effective treatments to alleviate AD are still not currently available. Hence, we explored markers and underlying molecular mechanisms by utilizing gene expression profiles CSVD patients from public databases, providing more options for early diagnosis its treatment. Methods Gene were collected GSE63060 (for AD) GSE162790 CSVD). Differential analysis was performed between mild cognitive...
Abstract In Alzheimer’s disease (AD), neuronal death is one of the key pathology. However, initiation in AD far from clear, and new targets are urgently needed to develop effective therapeutic methods. This study analyzed sequencing data single-cell RNAseq spatialomics, revealed impact global mapping cell spatial distribution relationships early stage AD. We found that microglia subpopulation Mic_PTPRG can anchor neurons based on ligand-receptor interaction pairs cause ectopic expression...