DNA methylation plays crucial roles during fetal development as well aging. Whether the aging of brain is programmed at stage remains untested. To test this hypothesis, mouse epigenetic clock (epiclock) was profiled in (gestation day 15), postnatal (day 5), and (week 70) male female C57BL/6J inbred mice. Data analysis showed that on week 70, epigenetically younger than brain. Predictive modeling by neural network identified specific methylations developing stages were predictive state...

Mice lacking caveolin-1 (Cav1), a key protein of plasma membrane, exhibit brain aging at an early adult stage. Here, integrative analyses metabolomics, transcriptomics, epigenetics, and single-cell data were performed to test the hypothesis that metabolic deregulation fetal due ablation Cav1 is linked in these mice. The results this study show lack caused lipid amino acid metabolism brain, genes associated with deregulated metabolites significantly altered upon aging. Moreover, several...

Caveolin-1 (Cav1) is a major plasma membrane protein that plays important functions in cellular metabolism, proliferation, and senescence. Mice lacking Cav1 show abnormal gene expression the fetal brain. Though evidence for placental influence on brain development emerging, whether ablation of affects regulation brain–placental axis remains unexamined. The current study tests hypothesis changes specific cells placenta are linked to deregulation Cav1-null mice. By performing single-nuclei RNA...

The objective of this study was to investigate gene regulation the developing fetal brain from congenic or inbred mice strains that differed in longevity. Gene expression and alternative splice variants were analyzed a genome-wide manner C57BL/6J (long-lived) comparison B6.Cg-

Abstract In this study, the transcriptional repressor REST (Repressor Element 1 Silencing Transcription factor) was ablated in mouse placenta to investigate molecular and cellular impacts on offspring brain at different life stages. Ablation of placental deregulated several metabolites, including glucose lactate that fuel energy, vitamin C (ascorbic acid) functions epigenetic programming during postnatal development, glutamate creatine help respond stress conditions adult life. Bulk RNA‐seq...

Abstract DNA methylation plays crucial roles during fetal development as well aging. Whether the aging of brain is programmed at stage remains untested. To test this hypothesis, mouse epigenetic clock (epiclock) was profiled in (gestation day 15), postnatal (day 5), and (week 70) male female C57BL/6J inbred mice. Data analysis showed that on week 70 epigenetically younger than brain. Predictive modeling by neural network identified specific methylations developing stages were predictive...

Abstract Caveolin-1 ( Cav1 ) encodes a major protein of the lipid rafts, called caveolae, which are plasma membrane invaginations found in most cells mammals. -null mice, at an early adult age, exhibit symptoms that hallmarks Alzheimer’s disease, and show brain aging similar to one half year old wildtype mice. In present study, integrative analysis metabolomics, transcriptomics, epigenetics single cell data was performed test hypothesis metabolic deregulation fetal due lack influenced these...