A5004840680- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Mitochondrial Function and Pathology
- Rabies epidemiology and control
- interferon and immune responses
- RNA regulation and disease
- Political and Economic history of UK and US
- RNA Research and Splicing
- Infective Endocarditis Diagnosis and Management
- Zoonotic diseases and public health
- Metal-Catalyzed Oxygenation Mechanisms
- Machine Learning in Bioinformatics
- Metabolism and Genetic Disorders
- Yersinia bacterium, plague, ectoparasites research
- Marine animal studies overview
- Social Sciences and Policies
- Bat Biology and Ecology Studies
- Gothic Literature and Media Analysis
- Metalloenzymes and iron-sulfur proteins
- Cancer-related molecular mechanisms research
- Transplantation: Methods and Outcomes
- Genomics and Phylogenetic Studies
- Viral Infections and Vectors
- Photosynthetic Processes and Mechanisms
- Science, Research, and Medicine
Emory University
2023-2024
Université de Corse Pascal Paoli
2024
Aix-Marseille Université
2024
Trinity University
2014
University of North Carolina at Chapel Hill
2007-2013
The mammalian mitochondrial genome encodes 13 proteins, which are synthesized at the direction of nine monocistronic and two dicistronic mRNAs. These mRNAs lack both 5′ 3′ untranslated regions. mechanism by specialized translational apparatus locates start codons initiates translation these leaderless is currently unknown. To better understand this mechanism, secondary structures near all open reading frames have been analyzed using RNA SHAPE chemistry. extent structure in as assessed...
Interferon inducible protein kinase PKR is an essential component of innate immunity. It activated by long stretches dsRNA and provides the first line host defense against pathogens inhibiting translation initiation in infected cell. Many cellular viral transcripts contain nucleoside modifications and/or tertiary structure that could affect activation. We have previously demonstrated a 5′-end triphosphate–a signature certain bacterial transcripts–confers ability relatively unstructured model...
In Latin America, rabies virus has persisted in a cycle between Desmodus rotundus vampire bats and cattle, potentially enhanced by deforestation. We modeled bovine outbreaks Costa Rica relative to land-use indicators found spatial-temporal relationships among with deforestation as predictor.
Anthropogenic land-use change alters wildlife habitats and modifies species composition, diversity, contacts among wildlife, livestock, humans. Such human-modified ecosystems have been associated with emerging infectious diseases, threatening human animal health. However, disturbance also creates new resources that some can exploit. Common vampire bats (Desmodus rotundus) in Latin America constitute an important example, as their adaptation to livestock blood-feeding has implications for...
Mammalian mitochondria use a streamlined decoding mechanism requiring only 22 tRNAs, which are all encoded in the mitochondrial genome. The genes encoding mammalian tRNAs hotspots for mutations leading to human disease. One tRNA with 3 known disease causing is tRNAMet. To understand how each of these affects structure tRNAMet we have used SHAPE chemistry investigate wild-type and mutant transcripts. mutation (U8C) results growth retardation, dystrophic muscles exercise intolerance afflicted...
The translational apparatus of human mitochondria requires only 22 tRNAs, which are encoded by the mitochondrial genome. tRNA genes hotspots for disease causing mutations. single Met (hmtRNA ) has 3 known One these (U8C) results in loss a specific Mg 2+ binding site, leading to an incorrectly folded that is poorly aminoacylated. A second mutation (A37G) hmtRNA associated with Leber's Hereditary Optical Neuropathy. A37G mutant, located anticodon loop , retains wild‐type structure,...
High school teacher Christie Jones chooses to teach a novel by Stephen King as her end-of-the-year literature unit. In addition the novel’s appropriateness yearlong themes of American literature, shows how this selection helps achieve goals get students practice reading and discussing apply these skills beyond English classroom.