A5085505370- Viral Infections and Vectors
- Bat Biology and Ecology Studies
- Zoonotic diseases and public health
- COVID-19 epidemiological studies
- Yersinia bacterium, plague, ectoparasites research
- Rabies epidemiology and control
- Mosquito-borne diseases and control
- Evolution and Genetic Dynamics
- Bartonella species infections research
- Malaria Research and Control
- Animal Disease Management and Epidemiology
- Respiratory viral infections research
- Gamma-ray bursts and supernovae
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Outbreaks Research
- Autopsy Techniques and Outcomes
- Marine animal studies overview
- SARS-CoV-2 detection and testing
- Astrophysics and Cosmic Phenomena
- Environmental DNA in Biodiversity Studies
- Vector-borne infectious diseases
- Insect symbiosis and bacterial influences
- Gothic Literature and Media Analysis
- Dengue and Mosquito Control Research
University of Oklahoma
2023-2025
Emory University
2021-2024
Aix-Marseille Université
2024
Université de Corse Pascal Paoli
2024
Universidad de Costa Rica
2016-2022
Institut Pasteur
2022
Pasteur Institute of Iran
2022
Université Paris-Saclay
2022
Hôpital Ambroise-Paré
2022
Assistance Publique – Hôpitaux de Paris
2022
Emerging infectious diseases, biodiversity loss, and anthropogenic environmental change are interconnected crises with massive social ecological costs. In this Review, we discuss how pathogens parasites responding to global change, the implications for pandemic prevention conservation. Ecological evolutionary principles help explain why both pandemics wildlife die-offs becoming more common; land-use loss often followed by an increase in zoonotic vector-borne diseases; some species, such as...
Several studies have shown Dengue Virus (DENV) nucleic acids and/or antibodies present in Neotropical wildlife including bats, suggesting that some bat species may be susceptible to DENV infection. Here we aim elucidate the role of house-roosting bats transmission cycle. Bats were sampled households located high and low dengue incidence regions during rainy dry seasons Costa Rica. We captured 318 from 12 different 29 households. Necropsies performed 205 analyze virus presence heart, lung,...
The ability of multiple bat species to host zoonotic pathogens without showing disease has fostered growing interest in immunology, indicating ways immune systems may differ between bats and other vertebrates. However, interspecific variation immunological diversity among only begun be recognized. order Chiroptera accounts for over 20% all mammal shows extreme a suite correlated ecological traits, such that should not expected immunologically homogenous. Here, we review the evolutionary...
Many of the world's most pressing issues, such as emergence zoonotic diseases, can only be addressed through interdisciplinary research. However, findings research are susceptible to miscommunication among both professional and non-professional audiences due differences in training, language, experience, understanding. Such contributes misunderstanding key concepts or processes hinders development effective agendas public policy. These misunderstandings also provoke unnecessary fear have...
Thousands of scientists and practitioners conduct research on infectious diseases wildlife. Rapid comprehensive data sharing is vital to the transparency actionability their work, but unfortunately, most efforts designed publically share these are focused pathogen determination genetic sequence data. Other facets existing surveillance – particularly negative results often withheld or, at best, summarized in a descriptive table with limited metadata. As result, very few datasets wildlife...
Bats carry many zoonotic pathogens without showing pronounced pathology, with a few exceptions. The underlying immune tolerance mechanisms in bats remain poorly understood, although information-rich omics tools hold promise for identifying wide range of markers and their relationship infection. To evaluate the generality responses to infection, we assessed differences similarities serum proteomes wild vampire ( Desmodus rotundus ) across infection status five taxonomically distinct...
Dengue virus (DENV) (Flavivirus, Flaviviridae) is a reemerging arthropod-borne with worldwide circulation, transmitted mainly by Aedes aegypti and albopictus mosquitoes. Since the first detection of its main transmitting vector in 1992 invasion DENV-1 1993, Costa Rica has faced dengue outbreaks yearly. In 2007 2013, experienced two largest terms total severe cases. To provide genetic information about etiologic agents producing these outbreaks, we conducted phylogenetic analysis viruses...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally, and the number of worldwide cases continues to rise. The zoonotic origins SARS-CoV-2 its intermediate potential spillback host reservoirs, besides humans, remain largely unknown. Because ethical experimental constraints more important, reduce refine animal experimentation, we used our repository well-differentiated airway epithelial cell (AEC) cultures from various domesticated wildlife species assess their...
Recently, two new influenza A-like viruses have been discovered in bats, A/little yellow-shouldered bat/Guatemala/060/2010 (HL17NL10) and A/flat-faced bat/Peru/033/2010 (HL18NL11). The hemagglutinin (HA)-like (HL) neuraminidase (NA)-like (NL) proteins of these lack hemagglutination activities, despite their sequence structural homologies with the HA NA conventional A viruses. We now investigated whether NS1 HL17NL10 HL18NL11 can functionally replace protein a virus. For this purpose, we...
To determine Bartonella spp. dynamics, we sampled bats and bat flies across 15 roosts in Costa Rica. PCR indicated prevalence of 10.7% 29.0% ectoparasite pools. Phylogenetic analysis 8 sequences from 5 fly pools revealed 11 distinct genetic variants, including 2 potentially new genotypes.
In Latin America, rabies virus has persisted in a cycle between Desmodus rotundus vampire bats and cattle, potentially enhanced by deforestation. We modeled bovine outbreaks Costa Rica relative to land-use indicators found spatial-temporal relationships among with deforestation as predictor.
Abstract Characterizing host–virus associations is critical due to the rising frequency of emerging infectious diseases originating from wildlife. Past analyses have evaluated zoonotic risk as binary, but virulence and transmissibility can vary dramatically. Recent work suggests bats harbor more viruses with high in humans than other taxa. However, it remains unknown whether all equal potential. We used phylogenetic factorization flexibly identify clades mammals (at any taxonomic level)...
Abstract Cave-dwelling bats' persistence in degraded habitats provides a unique opportunity to examine the dual effects of community structure versus habitat degradation on disease prevalence. To evaluate how disturbance and cave complexity influenced bat composition prevalence multiple pathogens communities, we conducted surveys 15 caves Costa Rica along an anthropogenic gradient. Collecting samples from 1,238 individuals, representing 17 species four families, determined common divergent...
Abstract A major challenge in ecology and evolution is to disentangle the known effects of community structure habitat degradation on disease prevalence, as they often act simultaneously natural systems. However, cave-dwelling bats persist degraded habitats, providing a unique opportunity examine these dual effects. We evaluated how disturbance cave complexity influenced bat composition prevalence multiple pathogens at level. During wet dry season surveys 15 caves Costa Rica along gradient...
Objetivo: Evaluar, bajo una perspectiva ecológica, la presencia de Aedes albopictus y su infección natural por virus dengue (DENV) en zona actividad piñera Costa Rica.Métodos: Se colectaron mosquitos adultos galerías forestales colindantes con piñeras, viviendas proximidad a cultivos (<1 Km) lejanía (1-10 Km). empleó el índice Shannon-Wiener para estimar biodiversidad. La infestación larvaria se evaluó plantas piña viviendas, calcularon índices aédicos (IV) contenedores (IC). Mediante...
Anthropogenic land-use change alters wildlife habitats and modifies species composition, diversity, contacts among wildlife, livestock, humans. Such human-modified ecosystems have been associated with emerging infectious diseases, threatening human animal health. However, disturbance also creates new resources that some can exploit. Common vampire bats (Desmodus rotundus) in Latin America constitute an important example, as their adaptation to livestock blood-feeding has implications for...