A5063042909- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Antifungal resistance and susceptibility
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Fungal Infections and Studies
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Mosquito-borne diseases and control
- Virology and Viral Diseases
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Infective Endocarditis Diagnosis and Management
- Bacillus and Francisella bacterial research
- Streptococcal Infections and Treatments
- Biosensors and Analytical Detection
- Antibiotic Resistance in Bacteria
- Rabies epidemiology and control
- Vector-borne infectious diseases
- Antimicrobial Resistance in Staphylococcus
- Animal Virus Infections Studies
- Long-Term Effects of COVID-19
- Bartonella species infections research
- Microbial infections and disease research
- Amoebic Infections and Treatments
Indiana University School of Medicine
2016-2025
Indiana University – Purdue University Indianapolis
2016-2025
Indiana University Health
2016-2025
University School
2020-2024
Riley Hospital for Children
2020-2024
Indiana University
2018-2024
Indiana University Indianapolis
2022-2023
Eskenazi Health Foundation
2020
Eskenazi Health
2020
Icahn School of Medicine at Mount Sinai
2017
Lower respiratory tract infections, including hospital-acquired and ventilator-associated pneumonia, are common in hospitalized patient populations. Standard methods frequently fail to identify the infectious etiology due polymicrobial nature of specimens necessity ordering specific tests viral agents. The potential severity these infections combined with a failure clearly causative pathogen results administration empirical antibiotic agents based on clinical presentation other risk factors.
The ability to provide timely identification of the causative agents lower respiratory tract infections can promote better patient outcomes and support antimicrobial stewardship efforts. Current diagnostic testing options include culture, molecular testing, antigen detection. These methods may require collection various specimens, involve extensive sample treatment, suffer from low sensitivity long turnaround times. This study assessed performance BioFire FilmArray Pneumonia Panel (PN panel)...
Systemic vascular injury occurs in coronavirus disease 2019 (COVID-19) patients; however, the underlying mechanisms remain unknown. To clarify role of inflammatory factors COVID-19 injury, we used a multiplex immunoassay to profile 65 cytokines/chemokines/growth plasma samples from 24 hospitalized (severe/critical) patients, 14 mild/moderate cases, and 13 healthy controls (HCs). patients had significantly higher levels 20 analytes than HCs. Surprisingly, only 1 cytokine, macrophage migration...
A bloodstream infection with Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA), is a serious condition that carries high mortality rate and also associated significant hospital costs. The rapid accurate identification differentiation of methicillin-susceptible (MSSA) MRSA directly from positive blood cultures has demonstrated benefits in both patient outcome cost-of-care metrics. We compare the next-generation Xpert MRSA/SA BC (Xpert) assay to GeneOhm StaphSR (GeneOhm)...
Common causes of chronic diarrhea among travelers worldwide include protozoan parasites. The majority parasitic infections are caused by Giardia duodenalis, Entamoeba histolytica, Cryptosporidium parvum, and hominis Similarly, these species cause the acquired in United States. Detection parasites gold standard microscopic methods is time-consuming requires considerable expertise; enzyme immunoassays direct fluorescent-antibody (DFA) stains have lowered hands-on time for testing, but...
The QIAstat-Dx Respiratory Panel (QIAstat-Dx RP) is a multiplex in vitro diagnostic test for the qualitative detection of 20 pathogens directly from nasopharyngeal swab (NPS) specimens. assay performed using simple sample-to-answer platform with results available approximately 69 min. identified are adenovirus, coronavirus 229E, HKU1, NL63, OC43, human metapneumovirus A and B, influenza A, H1, H3, H1N1/2009, parainfluenza virus 1, 2, 3, 4, rhinovirus/enterovirus, respiratory syncytial...
The cornerstone of treatment for acute cholangitis is source control with biliary drainage and early antibiotics. primary aim this study was to describe the microbiology bile aspirate pathogens obtained at time endoscopic retrograde cholangiopancreatography (ERCP) in patients suspected having cholangitis.In single-center retrospective study, were included if a collected ERCP suspicion cholangitis, from 1 January 2010 31 December 2016.There 721 procedures culture results, 662 positive...
ABSTRACT Candida auris is a multidrug-resistant opportunistic fungal pathogen capable of causing serious infections and healthcare-associated outbreaks. Screening for colonization with C. has become routine recommended in many hospitals healthcare facilities as an infection control prevention strategy. Subsequently, since there are currently no FDA-approved tests this purpose, clinical microbiology laboratories have responsible developing protocols to detect using axial inguinal screening...
ABSTRACT A paucity of effective, currently available antibiotics and a lull in antibiotic development pose significant challenges for treatment patients with multidrug-resistant (MDR) Acinetobacter baumannii infections. Thus, novel therapeutic strategies must be evaluated to meet the demands these often life-threatening Accordingly, we examined activity gallium protoporphyrin IX (Ga-PPIX) against collection A. strains, including nonmilitary military strains representing different clonal...
Automation of the clinical microbiology laboratory has become more prominent as laboratories face higher specimen volumes and understaffing are becoming consolidated. One recent advancement is use digital image analysis to rapidly distinguish between chromogenic growth for screening bacterial cultures. In this study, colony segregation software developed by Copan (Brescia, Italy) was evaluated significant no urine cultures plated onto standard blood MacConkey agars.
Bats carry many zoonotic pathogens without showing pronounced pathology, with a few exceptions. The underlying immune tolerance mechanisms in bats remain poorly understood, although information-rich omics tools hold promise for identifying wide range of markers and their relationship infection. To evaluate the generality responses to infection, we assessed differences similarities serum proteomes wild vampire ( Desmodus rotundus ) across infection status five taxonomically distinct...
Zika virus (ZIKV) is responsible for an ongoing and intensifying epidemic in the Western Hemisphere. We examined complete predicted proteomes, glycomes, selectomes of 33 ZIKV strains representing temporally diverse members African lineage, Asian current outbreak Americas. Derivation selectome 'omics' approach to identify distinct evolutionary pressures acting on different features organism. Employment M8 model did not show evidence global diversifying selection polyprotein; however, a mixed...
Cutaneous blastomycosis (CB) is associated with a variety of skin manifestations. Among other entities, CB may be mistaken for pyoderma gangrenosum due to overlap findings on histopathologic examination. We report case CB, initially diagnosed as and treated steroids, leading disseminated acute respiratory distress syndrome (ARDS).
Francisella philomiragia is a very uncommon pathogen of humans. Diseases caused by it are protean and have been reported largely in near-drowning victims those with chronic granulomatous disease. We present case F. pneumonia peripheral edema bacteremia renal transplant patient review the diverse reports infections.