A5004626755- Cancer and Skin Lesions
- Vascular Tumors and Angiosarcomas
- Nonmelanoma Skin Cancer Studies
- Tumors and Oncological Cases
- Cutaneous Melanoma Detection and Management
- Sarcoma Diagnosis and Treatment
- Histiocytic Disorders and Treatments
- Melanoma and MAPK Pathways
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- CNS Lymphoma Diagnosis and Treatment
- Soft tissue tumor case studies
- Hedgehog Signaling Pathway Studies
- melanin and skin pigmentation
- Renal cell carcinoma treatment
- Ear and Head Tumors
- Vascular Malformations and Hemangiomas
- Neurofibromatosis and Schwannoma Cases
- Inflammatory Myopathies and Dermatomyositis
- Metastasis and carcinoma case studies
- Dermatologic Treatments and Research
- Mast cells and histamine
- Respiratory viral infections research
- Entomological Studies and Ecology
- Skin and Cellular Biology Research
Cleveland Clinic
2020-2025
Cleveland Clinic Lerner College of Medicine
2023-2024
Goshen College
2024
Case Western Reserve University
2024
The University of Texas MD Anderson Cancer Center
2019-2023
Keiser University
2021
Medical College of Wisconsin
2016-2020
University of Santo Tomas Hospital
2019
Universitätsklinikum Erlangen
2017
University of Mississippi Medical Center
2017
Lower respiratory tract infections, including hospital-acquired and ventilator-associated pneumonia, are common in hospitalized patient populations. Standard methods frequently fail to identify the infectious etiology due polymicrobial nature of specimens necessity ordering specific tests viral agents. The potential severity these infections combined with a failure clearly causative pathogen results administration empirical antibiotic agents based on clinical presentation other risk factors.
The ability to provide timely identification of the causative agents lower respiratory tract infections can promote better patient outcomes and support antimicrobial stewardship efforts. Current diagnostic testing options include culture, molecular testing, antigen detection. These methods may require collection various specimens, involve extensive sample treatment, suffer from low sensitivity long turnaround times. This study assessed performance BioFire FilmArray Pneumonia Panel (PN panel)...
Pilomatrical tumors include pilomatricoma, melanocytic matricoma, and pilomatrical carcinoma. Similar to the normal anagen hair follicle bulb, they may be associated with benign and, rarely, atypical pigmented dendritic melanocytes. It has been recently suggested that term "melanocytic matricoma" replaced "pilomatricoma hyperplasia" (PMMH). Occasional cases of PMMH show intermediate grades histological atypia. Their clinical behavior is uncertain. Interestingly, we found in one these a...
Acral melanocytic neoplasms often pose diagnostic difficulty. Preferentially expressed antigen in melanoma (PRAME) expression and loss of p16 have utility tumors. We examined PRAME 30 acral (n = 11 nevi; n 2 dysplastic 7 Spitz 10 melanomas). was scored as % positive nuclei: negative 0%; 1% to 25% 1+; 50% 2+; 75% 3+, or positive: 100% 4+. defined retained (homogeneous checkerboard) lost (complete partial/regionally). all benign, dysplastic, nevi. Conversely, melanomas were diffusely (4+) for...
Abstract MC1R, a G-protein coupled receptor, triggers ultraviolet light-induced melanin synthesis and DNA repair in melanocytes is implicated the pathogenesis of melanoma. Although widely expressed different tissue types, its function non-cutaneous relatively unknown. Herein, we demonstrate that disruptive MC1R variants associated with melanomagenesis are less frequently found patients several cancers. Further exploration revealed breast cancer shows significantly higher expression than...
Spitzoid melanocytic neoplasms are diagnostically challenging; criteria for malignancy continue to evolve. The ability predict chromosomal abnormalities with immunohistochemistry (IHC) could help select cases requiring evaluation.Fluorescence in situ hybridization (FISH)-tested spitzoid at our institution (2013-2021) were reviewed. p16, BRAF V600E, and preferentially expressed antigen melanoma (PRAME) IHC results correlated FISH.A total of 174 (1.9F:1M, median age 28 years; range, 5...
Background The full‐blown lesion of granuloma annulare (GA) is characterized by necrobiotic granulomas with palisading histiocytes and stromal mucin deposition. Cases in which the granulomatous features are not fully developed have been described as “interstitial” variant; however, there no good definition regarding their criteria for diagnosis. Methods We conducted a retrospective study 97 cases GA. Results interstitial GA (69) were paucicellular scant to mucin, only few scattered...
Low-grade fibromyxoid sarcoma (LGFMS) typically involves deep soft tissue (beneath the fascia) of proximal extremities and trunk. Long-term follow-up has shown a high rate local recurrence, metastasis, death. To best our knowledge, there is only one previous large series focusing on superficial LGFMS suggesting tumors are disproportionately more common in children may have better prognosis. Our study's primary goals to confirm these findings increase general awareness that arise tissue.We...
Nipple adenoma (NA) is a rare, benign proliferation of the nipple ducts. It may be clinically mistaken for Paget disease or squamous cell carcinoma; thus, microscopic evaluation paramount. A large case series NA has not been undertaken since 1980s. Therefore, we undertook this study to evaluate clinicopathologic characteristics NA, emphasizing differential diagnoses and follow-up data. We retrieved 50 cases from our in-house archives consultation files between 2003 2022. Available slides...
It is well-known to pathologists that melanoma "the great mimicker" and can look like anything. Despite this widespread awareness, the diagnosis remains a continuous challenge, especially when metastatic with rare morphology examined. We report case of 64-year-old man lung mass right-sided pleural effusion who underwent video-assisted thoracoscopic surgery for decortication. The history was not reported us. Microscopic examination revealed sheets small round blue cells infiltrating into...
Carcinocythemia is a rare phenomenon defined as morphologically identifiable, circulating tumor cells in the peripheral blood. No modern case series of carcinocythemia exists literature.Blood smears from patients were reviewed and associated clinicopathologic findings described compared to literature. When available, bone marrows examined.We identified 7 cases over 3 years at our institution 5 females 2 males with median age 57 compare them 26 reports literature (19 females, 10 males; 57)....
Polymorphous sweat gland carcinoma is an uncommon low-grade malignant adnexal tumor with a marked predilection for the distal extremities. Histologically, lesions are characterized by cellular proliferation showing combination of growth patterns, including trabecular, solid, tubular, cribriform, or adenoid cystic and pseudopapillary. The immunohistochemical molecular profile these tumors has not yet been properly addressed. We have studied 3 cases polymorphous using broad panel markers...
Abstract: Cutaneous metastasis may be the initial sign of internal malignancy but more often represents a late manifestation widely disseminated disease. Breast carcinoma is most common to metastasize skin. Although several studies have detailed histopathologic patterns cutaneous from malignancies, very little has been published regarding metastases breast Furthermore, and clinical features observed in cases with local skin involvement as opposed exhibiting distant not adequately...