A5013363631- Genetics, Aging, and Longevity in Model Organisms
- Radiation Detection and Scintillator Technologies
- Animal Genetics and Reproduction
- Ferroptosis and cancer prognosis
- Nuclear Physics and Applications
- Heat shock proteins research
- Semiconductor materials and interfaces
- Circadian rhythm and melatonin
- Nanowire Synthesis and Applications
- Particle Detector Development and Performance
- 2D Materials and Applications
- RNA modifications and cancer
- Birth, Development, and Health
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
Michigan United
2024
University of Michigan
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023
Chongqing Medical University
2023
Institute of High Energy Physics
2022
Chinese Academy of Sciences
2022
China Spallation Neutron Source
2022
Metastasis is the stage at which prognosis substantially decreases for many types of cancer. The ability tumor cells to metastasize dependent upon characteristics cells, and conditioning distant tissues that support colonization by metastatic cells. In this report, we investigated systemic alterations in caused multiple human breast cancer cell lines impact these on phenotype. We observed niche within lung, a common site, was significantly altered MDA-MB-231, MCF7, T47 tumors, lung...
Sex determination in the nematode C . elegans is controlled by master regulator XOL-1 during embryogenesis. Expression of xol-1 dependent on ratio X chromosomes and autosomes, which differs between XX hermaphrodites XO males. In males, highly expressed hermaphrodites, at very low levels. activity known to be critical for proper development but its expression was considered minimal importance hermaphrodite embryos. Our study reveals that plays an important role as a developmental timing Using...
Abstract The C. elegans nuclear hormone receptor sex-1 is known to be an embryonic X-signal element that represses xol-1 , the sex-switch gene master regulator of sex determination and dosage compensation. Several prior studies on function have suggested may additional downstream roles beyond regulation expression. In this study we characterize some these in regulating dual processes compensation during embryogenesis. Our reveals acts many targets a -independent manner. Further analysis...
Cutaneous squamous cell carcinoma (CSCC) is a malignant tumor originating from epidermal keratinocytes. In various types of tumors, ferroptosis vital iron-dependent form regulated death. Recent studies suggest that heat shock protein 27 (HSP27), encoded by the family B member 1 (HSPB1) gene, involved in regulation ferroptosis, but specific mechanism remains unclear. this study, CSCC lines were transfected with lentivirus-mediated HSPB1-shRNA or lentivirus carrying overexpressed HSPB1. lines,...