A5095070592- Genetics, Aging, and Longevity in Model Organisms
- CRISPR and Genetic Engineering
- Animal Genetics and Reproduction
- Chromosomal and Genetic Variations
University of Michigan
2024-2025
Michigan United
2025
Dosage compensation in Caenorhabditis elegans equalizes X-linked gene expression between XX hermaphrodites and XO males. The process depends on a condensin-containing dosage complex (DCC), which binds the X chromosomes to repress by factor of 2. Condensin I DC an additional five DCC components must be present during early embryogenesis establish compensation. However, whether DCC’s continued presence is required maintain repressed state once established unknown. Beyond role condensin...
Abstract Dosage compensation in Caenorhabditis elegans equalizes X-linked gene expression between XX hermaphrodites and XO males. The process depends on a condensin-containing dosage complex (DCC), which binds the X chromosomes to repress expression. Condensin I DC an additional five DCC components must be present during early embryogenesis establish compensation. However, whether DCC’s continued presence is required maintain repressed state once established unknown. Beyond role of condensin...
Abstract The C. elegans nuclear hormone receptor sex-1 is known to be an embryonic X-signal element that represses xol-1 , the sex-switch gene master regulator of sex determination and dosage compensation. Several prior studies on function have suggested may additional downstream roles beyond regulation expression. In this study we characterize some these in regulating dual processes compensation during embryogenesis. Our reveals acts many targets a -independent manner. Further analysis...