A5091559675- Genetic diversity and population structure
- Genetic and phenotypic traits in livestock
- Chromosomal and Genetic Variations
- Sperm and Testicular Function
- Skin and Cellular Biology Research
- Hair Growth and Disorders
- Phytoestrogen effects and research
- Wnt/β-catenin signaling in development and cancer
- Animal Virus Infections Studies
- Genomics and Chromatin Dynamics
- Cancer-related Molecular Pathways
- Reproductive Biology and Fertility
- Circular RNAs in diseases
- DNA Repair Mechanisms
- MicroRNA in disease regulation
- Animal Diversity and Health Studies
- Cancer-related molecular mechanisms research
Sichuan Agricultural University
2024-2025
Ministry of Agriculture and Rural Affairs
2025
Qingdao Agricultural University
2024
First People's Hospital of Yunnan Province
2024
Kunming University of Science and Technology
2024
Structural Genomics Consortium
2019
University of Toronto
2019
Abstract Melatonin (MLT) is a circadian hormone that reportedly influences the development and cyclic growth of secondary hair follicles; however, mechanism regulation remains unknown. Here, we systematically investigated role MLT in regeneration using depilation mouse model. We found supplementation significantly promoted model, whereas receptor antagonist luzindole suppressed regeneration. By analysing gene expression dynamics between group luzindole‐treated groups, revealed up‐regulated...
Background Optimizing buck semen preservation techniques can significantly advance the goat industry. This study aimed to investigate effects of chitosan on sperm quality and seminal plasma metabolite profiles in bucks during low-temperature storage at 4°C. Results The results showed that when 0.2 mg/mL was added dilution, viability antioxidant capacity were highest higher than control group ( p < 0.05). Sperm decreased progressively with increasing time However, day 5, all groups...
Abstract Background Breast cancer is a highly prevalent disease worldwide, and early diagnosis treatment could reduce the mortality rate of breast patients. microRNAs (miRNA) have been shown to regulate occurrences progression many types cancers. Thus, it crucial find novel biomarkers in cancer. miR‐449c‐5p acted as biomarker non‐small cell lung cancer, gastric carcinoma, so forth. ERBB2 an ideal target for therapy. However, molecular mechanisms between remain poorly understood. Our study...
Semen cryopreservation acts a crucial role in enhancing breed improvement and conserving genetic resources. However, it often leads to decreased sperm activity reduced pregnancy rates. Despite significant advancements semen freezing techniques for goats, the precise factors mechanisms causing cryo-injury remain unclear.
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI
Summary MBTD1, a H4K20me reader, has recently been identified as component of the NuA4/TIP60 acetyltransferase complex, regulating gene expression and DNA repair. inhibits 53BP1 binding to chromatin through recognition mark by MBTD1 acetylation H2AK15, blocking ubiquitination required for localization at breaks. The non-catalytic subunit EPC1 enlists into but detailed molecular mechanism remains incompletely explored. Here, we present crystal structure MBTD1-EPC1 revealing hydrophobic...