A5112514248- Ovarian cancer diagnosis and treatment
- Advanced Breast Cancer Therapies
- Fungal Biology and Applications
- PI3K/AKT/mTOR signaling in cancer
- Kruppel-like factors research
- Chinese history and philosophy
- Cancer-related Molecular Pathways
- Cancer Mechanisms and Therapy
- Urinary Bladder and Prostate Research
- Growth Hormone and Insulin-like Growth Factors
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- NF-κB Signaling Pathways
- Wnt/β-catenin signaling in development and cancer
- interferon and immune responses
- Liver Disease Diagnosis and Treatment
- Fungal and yeast genetics research
- Antifungal resistance and susceptibility
- Medicinal Plants and Bioactive Compounds
- Ginseng Biological Effects and Applications
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- Educational Philosophies and Pedagogies
- Chemokine receptors and signaling
- Sleep and Work-Related Fatigue
Chinese PLA General Hospital
2023-2025
Chinese People's Liberation Army
2023-2025
PLA Academy of Military Science
2024
People's Liberation Army No. 150 Hospital
2024
Bengbu Medical College
2022-2024
China Textile Academy
2023
Zhejiang Chinese Medical University
2023
Weatherford College
2022
Nanjing Medical University
2021-2022
Suzhou Municipal Hospital
2021-2022
Lapatinib (GW572016) is a selective inhibitor of both epidermal growth factor receptor (EGFR) and HER-2 tyrosine kinases. Here, we explore the therapeutic potential lapatinib by testing its effect on tumor cell in panel 31 characterized human breast cancer lines, including trastuzumab-conditioned HER-2-positive lines. We further characterize activity combination with trastuzumab analyze whether EGFR expression or changes induced activation EGFR, HER-2, Raf, AKT, extracellular...
Abstract Purpose: PD-0332991 is a selective inhibitor of the CDK4/6 kinases with ability to block retinoblastoma (Rb) phosphorylation in low nanomolar range. Here we investigate role inhibition human ovarian cancer. Experimental Design: We examined effects on proliferation, cell-cycle, apoptosis, and Rb using panel 40 established cancer cell lines. Molecular markers for response prediction, including p16 Rb, were studied gene expression profiling, Western blot, array CGH. Multiple drug...
This present study was designed to explore the protective role of Lactobacillus plantarum ZJUIDS14 against Non-alcoholic Fatty Liver Disease (NAFLD) in a high-fat-diet (HFD)-induced C57BL/6 mice model. The probiotic (109 CFU/every other day) administered by oral gavage for 12 weeks. We found that L. intervention significantly alleviated HFD related hepatic steatosis, liver damage, insulin resistance, and increased expression peroxisome proliferator activated receptor α (PPAR-α) while...
The recent identification of activating fibroblast growth factor receptor 2 (FGFR2) mutations in endometrial cancer has generated an opportunity for a novel target-based therapy. Here, we explore the therapeutic potential FGFR inhibitors, multikinase inhibitor dovitinib (TKI258) and more selective NVP-BGJ398 treatment cancer. We examined effects both inhibitors on tumor cell growth, FGFR2 signaling, cycle, apoptosis using panel 20 molecularly characterized human lines. Anchorage-independent...
Abstract This study investigated the impact of metabolic syndrome (MetS) and its components on prostate volume (PV) in general Chinese population. In total, 43 455 participants The First Medical Center PLA General Hospital (Beijing, China) from January 1, 2012, to December 31, 2022, undergoing health examinations were included study. Participants categorized into four groups according PV quartiles: Q1 (PV ≤24.94 ml), Q2 >24.94 ml ≤28.78 Q3 >28.78 ≤ 34.07 Q4 >34.07 with serving as...
Abstract Purpose: Insulin-like growth factor 1 receptor (IGF-IR) has been implicated in the pathogenesis of ovarian cancer. Ganitumab is an investigational, fully human monoclonal antibody against IGF-IR. Here, we explore therapeutic potential ganitumab for treatment Experimental Design: The effects were tested vitro a panel 23 established cancer cell lines. ability to inhibit IGF-I–, IGF-II–, and insulin-mediated signaling was examined tumor xenografts using models displaying...
ABSTRACT Aspergillus fumigatus is the predominant pathogen responsible for aspergillosis infections, with emerging drug-resistant strains complicating treatment strategies. The role of mitochondrial functionality in fungal resistance to antifungal agents well-documented yet not fully understood. In this study, protein Bcs1A, a homolog yeast Bcs1, was found regulate colony growth, ion homeostasis, and response drugs A. . Microscopic observations revealed substantial colocalization Bcs1A-GFP...
Previous observational studies have indicated that metabolic abnormalities are associated with benign prostatic hyperplasia (BPH). The limitations of the research methodology do not allow causal inference to be drawn; however, Mendelian randomization (MR) can clarify this.Using summary-level data from genome-wide association studies, we conducted a two-sample MR study examine causality syndrome (MetS) and its components on BPH (26,358 cases 110,070 controls). random-effects inverse-variance...
Drug resistance in fungal pathogens is a new challenge clinical aspergillosis treatment. Mitochondria as dynamic organelles are involved numerous biological processes fungi, including drug resistance. However, little known about the mechanism underlying mitochondrial regulation of response to antifungal drugs. Here, we showed that putative GTPase, GemA, yeast Gem1 homolog, crucial for azole and cell wall integrity opportunistic pathogen
Ultrathin fluoroacrylic emulsion coating wrapped effective microporous non-woven air filtration membranes of 0.2 μm thickness were made for PPE masks with up to 99.9% efficiencies both 0.3 NaCl aerosol particles and oily DEHS aerosols. An ultrasonic dip-coating process was applied the controllable formation a nano-protrusion morphology on fiber surface.
Abstract Background Previous observational studies have been controversial regarding the association of leukocyte telomere length (LTL) with prostate cancer (PCa) and benign prostatic hyperplasia (BPH). Methods First, we conducted an study utilizing UK Biobank data. The correlation between LTL risk PCa BPH was evaluated via multivariate-adjusted logistic regression. Then, a 2-sample Mendelian randomization to examine causal links (472 174 individuals) as well BPH. To verify reliability...
Aim To estimate the prevalence of nocturia in middle‐aged and elderly men evaluate its associated factors changes over time. Methods Data older aged ≥40 years from 2007–2008 2017–2020 cycles National Health Nutrition Examination Survey were retrospectively analyzed. The was estimated using participant questionnaires on nocturia, lifestyle‐related factors, health decadal examined multivariate logistic regression analysis to determine related with nocturia. Results 38.0% 39.6% 2017–2020, no...
Objective The global concern regarding the health implications of night shift work has escalated. Nevertheless, variations exist in observed association between and prostate cancer (PCa). This study aims to systematically explore risk PCa. Design Cohort Mendelian randomisation (MR) were used. Setting data was from UK Biobank (UKB). MR using Finngen UKB through Integrative Epidemiology Unit (IEU) Open Genome-Wide Association Study Project. Participants without prior PCa paid employment or...