About
Contact & Profiles
A5106059360
Research Areas
- Autophagy in Disease and Therapy
- Immune responses and vaccinations
- HIV Research and Treatment
- Vaccine Coverage and Hesitancy
- Mosquito-borne diseases and control
- Vibrio bacteria research studies
Roma Tre University
2025
Fondazione Santa Lucia
2025
Abstract Heterozygous mutations in the Bone morphogenetic protein (BMP) type I receptor ACVR1 , encoding activin-like kinase 2 (ALK2), underlie all cases of rare genetic musculoskeletal disorder Fibrodysplasia Ossificans Progressiva (FOP). The most commonly found mutant ALK2 p.R206H variant exhibits loss auto inhibition BMP signaling and can be activated by Activins, while wild-type receptors remain unresponsive. Consequently, downstream chondrogenic is enhanced, thus driving heterotopic...
10.1038/s41420-025-02393-0
article
EN
cc-by
Cell Death Discovery
2025-03-22
Coming Soon ...