A5027354252- Caveolin-1 and cellular processes
- Cell death mechanisms and regulation
- DNA Repair Mechanisms
- Cell Adhesion Molecules Research
- Cancer-related Molecular Pathways
- Autophagy in Disease and Therapy
- ATP Synthase and ATPases Research
- Receptor Mechanisms and Signaling
- Ubiquitin and proteasome pathways
- Ferroptosis and cancer prognosis
- Trypanosoma species research and implications
- Cancer, Lipids, and Metabolism
- Parasites and Host Interactions
- Research on Leishmaniasis Studies
- Carbohydrate Chemistry and Synthesis
- Mitochondrial Function and Pathology
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
Institute of Molecular Biology and Pathology
2022-2025
National Research Council
2022-2025
Sapienza University of Rome
2023
University of Rome Tor Vergata
2013-2018
Fondazione Santa Lucia
2014-2018
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2018
Macroautophagy/autophagy has been shown to exert a dual role in cancer i.e., promoting cell survival or death depending on the cellular context and stage. Therefore, development of potent autophagy modulators, with clear mechanistic understanding their target action, paramount importance both clinical studies. In process exploring mechanism action previously identified cytotoxic small molecule (SM15) designed microtubules interaction domain kinetochore component NDC80/HEC1, we discovered...
Caspase-8 is a key player in extrinsic apoptosis and its activity often downregulated cancer. However, human expression retained some tumors, including glioblastoma (GBM), suggesting that it may support cancer growth these contexts. GBM, the most aggressive of gliomas, characterized by extensive angiogenesis an inflammatory microenvironment development resistance to therapies. We have recently shown sustains neoplastic transformation vitro GBM cell lines. Here, we demonstrate Caspase-8,...
Abstract Heterozygous mutations in the Bone morphogenetic protein (BMP) type I receptor ACVR1 , encoding activin-like kinase 2 (ALK2), underlie all cases of rare genetic musculoskeletal disorder Fibrodysplasia Ossificans Progressiva (FOP). The most commonly found mutant ALK2 p.R206H variant exhibits loss auto inhibition BMP signaling and can be activated by Activins, while wild-type receptors remain unresponsive. Consequently, downstream chondrogenic is enhanced, thus driving heterotopic...
Neglected tropical diseases (NTDs), including trypanosomiasis, leishmaniasis, and schistosomiasis, result in a significant burden terms of morbidity mortality worldwide every year. Current antiparasitic drugs suffer from several limitations such as toxicity, no efficacy toward all the forms parasites' life cycle, and/or induction resistance. Histone-modifying enzymes play crucial role parasite growth survival; thus, use epigenetic has been suggested strategy for treatment NTDs. We tested...
Abstract Dissemination of high-grade serous ovarian cancer (HG-SOC) in the omentum and intercalation into a mesothelial cell (MC) monolayer depends on functional α5β1 integrin (Intα5β1) activity. Although binding Intα5β1 to fibronectin drives these processes, other molecular mechanisms linked inside-out signaling might support metastatic dissemination. Here, we report novel interactive that contributes activation accelerates tumor cells toward invasive disease, involving protein β-arrestin1...