Melanopsin functions in intrinsically photosensitive retinal ganglion cells of mammals to regulate circadian clock and pupil constriction. The opsinamide AA92593 has been reported specifically inhibit mouse human melanopsin as a competitive antagonist against retinal; however, the molecular mechanisms underlying its specificity have not resolved. In this study, we attempted identify amino acid residues responsible for susceptibility mammalian melanopsins AA92593. Our cell-based assays...

We extend a recently developed algorithm that expands the time-varying parameters onto single set of basis functions, to multiple sets functions. This feature allows capability capture many different dynamics may be inherent in system. A functions has its own unique characteristics can best system have similar features. Therefore, for systems dynamics, use not adequate. Computer simulation examples do indeed show benefit using over cases with switching dynamics. Moreover, proposed method...

Plagued by heterogeneous clutter, it is a serious challenge for airborne radars to detect low-altitude, weak targets. To overcome this problem, novel matrix information geometry detector multi-channel radar proposed in paper. The applies the given steering vector and array structure detection method so that can be used space–time adaptive detection. While improving performance, detector’s original anti-clutter advantage enhanced as well. simulation experiment results indicate has advantages...

Abstract Melanopsin functions in intrinsically photosensitive retinal ganglion cells of mammals to regulate circadian clock and pupil constriction. The opsinamide AA92593 has been reported specifically inhibit mouse human melanopsin as a competitive antagonist against retinal; however, the molecular mechanisms underlying its specificity have not resolved. In this study, we attempted identify amino acid residues responsible for specific interaction with mammalian melanopsins. Our cell-based...

A method is proposed to diagnose and identify faults in active nonlinear resistive circuits. The resistances are replaced by the current sources. nonlinearity of circuits exploited if occur resistances. When no fault occurs resistances, parameters linear dependent sources characteristics may be determined uniquely. multiple they also can uniquely under a certain condition.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>

The acquisition of inverse synthetic aperture radar (ISAR) images aircraft targets in complete attitude is challenging due to the non-cooperative nature targets. To determine characteristics scattering centers when changes, an effective center model based on ISAR proposed this letter. First, sensitivity target image azimuth and pitch analyzed. Then, a sinc mixture (SMM) imaging principle with aim describe center, method for estimating SMM's parameters are proposed. Finally, at arbitrary...

Abstract Due to the aircraft targets’ uncooperative character, acquiring complete scattering characteristics of enemy is challenging. An effective reconstruction method target centres based on analysis inverse synthetic aperture radar (ISAR) images proposed in this letter. First, a positive definite manifold characterizing ISAR different attitudes constructed. Then, Kullback–Leibler divergence used as measure variability between images. Finally, an image interpolation obtain with more...

Considering the characteristics of tropospheric scattering channel, including strong spatial directivity, link loss, multipath delay and so on, a channel simulation model based on OPNET MATLAB is proposed. This method simulates characteristics, time loss background noise by modifying stages blocking, propagation delay, received power pipes in 14 pipeline stage model, builds Simulink to simulate Rayleigh fading Doppler frequency shift channel. Finally, are analyzed experiment. The...

Inverse synthetic aperture radar (ISAR) images that characterize the complete scattering characteristics of enemy aircraft are difficult to be obtained due attitude sensitivity targets. An interpolation method based on principal component analysis (PCA) is proposed achieve ISAR in this paper. First, an image pre-processing reduce effect rotation characteristics. Then, principle PCA analyzed and a "pairwise" features corresponding eigenvalues inverse images. Finally, spherical manifold...