A5073843343- Neuroblastoma Research and Treatments
- Galectins and Cancer Biology
- Toxin Mechanisms and Immunotoxins
- RNA Research and Splicing
- Orthopaedic implants and arthroplasty
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Sarcoma Diagnosis and Treatment
- Ecology and Vegetation Dynamics Studies
- Cardiac tumors and thrombi
- Aeolian processes and effects
- Tumors and Oncological Cases
- Rangeland and Wildlife Management
- Immune Cell Function and Interaction
- Biomedical Text Mining and Ontologies
- Alzheimer's disease research and treatments
- Bioinformatics and Genomic Networks
- Head and Neck Cancer Studies
- Plant and animal studies
- Gastrointestinal Tumor Research and Treatment
- Vascular Tumors and Angiosarcomas
- Surgical site infection prevention
- Signaling Pathways in Disease
St. Christopher's Hospital for Children
2020-2021
Drexel University
2021
University of Pennsylvania
2017
Cincinnati Children's Hospital Medical Center
2016
University of Pennsylvania Health System
2016
The Huntington Library, Art Museum, and Botanical Gardens
2014
University of Miami
2014
Pennsylvania State University
2010-2014
University of Southern California
2012
Children's Hospital of Los Angeles
2010-2012
Tumor infiltration with Valpha24-invariant NKT cells (NKTs) associates favorable outcome in neuroblastoma and other cancers. Although NKTs can be directly cytotoxic against CD1d+ cells, the majority of human tumors are CD1d-. Therefore, role cancer remains largely unknown. Here, we demonstrate that CD68+ tumor-associated monocytes/macrophages (TAMs) represented CD1d-expressing primary neuroblastomas. TAMs stimulated growth cell lines their xenografts NOD/SCID mice via IL-6 production....
Abstract Interleukin-6 (IL-6) is a pleiotropic cytokine with broad range of physiologic and pathologic functions. Because in cancer, IL-6 contributes to microenvironment that promotes tumor cell survival, angiogenesis, inflammation, understanding the mechanism responsible for its production important. In neuroblastoma, second most common solid children, produced not by cells but stromal such as monocytes bone marrow mesenchymal stem (BMMSC). Here we show BMMSCs part stimulated galectin-3...
Prp2 is an RNA-dependent ATPase that activates the spliceosome before first transesterification reaction of pre-mRNA splicing. has extensive homology throughout helicase domain characteristic DEXD/H-box helicases and a conserved carboxyl-terminal also found in spliceosomal Prp16, Prp22, Prp43. Despite shared by these helicases, each distinct, sequential role splicing; thus, uncovering determinants specificity becomes crucial to understanding other DEAH-splicing helicases. Mutations 11-mer...
We identified Pumilio (Pum), a Drosophila translational repressor, in computational search for metazoan proteins whose activities might be regulated by assembly into ordered aggregates. The algorithm was based on evolutionary sequence conservation patterns observed yeast prion proteins, which contain aggregation-prone glutamine/asparagine (Q/N)-rich domains attached to functional of normal amino acid composition. examined aggregation Pum and its nematode ortholog PUF-9 expression yeast. A...
The Saccharomyces cerevisiae splicing factor Prp2 is an RNA-dependent ATPase required before the first transesterification reaction in pre-mRNA splicing. binds to spliceosome absence of ATP and released following hydrolysis. It contains three domains: a unique N-terminal domain, helicase domain that highly conserved DExD/H protein family, C-terminal spliceosomal DEAH proteins Prp2, Prp16, Prp22, Prp43. We examined role each by deletion mutagenesis. Whereas deletions either or are lethal,...
<div>Abstract<p>Interleukin-6 (IL-6) is a pleiotropic cytokine with broad range of physiologic and pathologic functions. Because in cancer, IL-6 contributes to microenvironment that promotes tumor cell survival, angiogenesis, inflammation, understanding the mechanism responsible for its production important. In neuroblastoma, second most common solid children, produced not by cells but stromal such as monocytes bone marrow mesenchymal stem (BMMSC). Here we show BMMSCs part...
<div>Abstract<p>Interleukin-6 (IL-6) is a pleiotropic cytokine with broad range of physiologic and pathologic functions. Because in cancer, IL-6 contributes to microenvironment that promotes tumor cell survival, angiogenesis, inflammation, understanding the mechanism responsible for its production important. In neuroblastoma, second most common solid children, produced not by cells but stromal such as monocytes bone marrow mesenchymal stem (BMMSC). Here we show BMMSCs part...
Abstract There is recent evidence that bone marrow-derived mesenchymal cells (BMMC) play an important role in metastasis several cancers, including myeloma and neuroblastoma. We previously reported neuroblastoma these are a source of interleukin-6 (IL-6) promotes the growth survival degradation. have recently isolated identified Galectin-3 binding protein (Gal-3BP) as soluble factor produced by cell line upregulating production IL-6 BMMC. Here we document Gal-3BP lines, particular those...
Multi-disciplinary teams present the framework in increasingly challenging care provided for patients. Wang et al. a 37 year old female who is 35 weeks pregnant when rare cardiac angiosarcoma diagnosed.