A5025591635- Ferroptosis and cancer prognosis
- Bladder and Urothelial Cancer Treatments
- Nanoplatforms for cancer theranostics
- Cancer, Lipids, and Metabolism
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Mitochondrial Function and Pathology
- Extracellular vesicles in disease
- Ocular and Laser Science Research
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Glutathione Transferases and Polymorphisms
- Wnt/β-catenin signaling in development and cancer
- Peptidase Inhibition and Analysis
- Inflammasome and immune disorders
- Organ Transplantation Techniques and Outcomes
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Cancer Research and Treatments
- Luminescence Properties of Advanced Materials
- Natural product bioactivities and synthesis
- Phosphodiesterase function and regulation
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Renal Transplantation Outcomes and Treatments
Shanghai First People's Hospital
2021-2025
Shanghai Jiao Tong University
2022-2023
Wenzhou Medical University
2020
Abstract Ischemia‐reperfusion injury (IRI) during kidney transplantation is linked to oxidative stress induced by excessive reactive oxygen species (ROS), which causes the of transplanted kidney, leading further intensified organ shortages. Protein‐based antioxidants have been developed for ROS scavenging via cascade biocatalyst. The in situ growth metal nanozymes on proteins effectively decreases steric hindrance between active sites, improving efficiency biocatalysts. However, poor...
Kidney transplantation is a crucial treatment option for end-stage renal disease patients, but challenges related to graft function, rejection and immunosuppressant side effects persist. This review highlights the potential of nanotechnology in addressing these challenges. Nanotechnology offers innovative solutions enhance organ preservation, evaluate mitigate ischemia-reperfusion injury improve drug delivery immunosuppressants. The integration holds promise improving outcomes kidney transplantation.
Abstract Background Enolase is an essential enzyme in the process of glycolysis and has been implicated cancer progression. Though dysregulation ENOs reported multiple cancers, their prognostic value specific role bladder (BLCA) remain unclear. Methods Multiple databases were employed to examine expression BLCA. The ENO1 was also validated BLCA cell lines tissue samples by western blotting immunohistochemistry. Kaplan–Meier analysis, ROC curve, univariate multivariate Cox regression...
The combination of Xiaozheng decoction with postoperative intravesical instillation has been shown to improve the prognosis bladder cancer patients and prevent recurrence. However, mechanisms underlying efficacy this herbal formula remain largely unclear. This research aims identify important components explore their anti-bladder effect mechanism using network pharmacology-based experiments.The chemical ingredients each herb in were collected from Traditional Chinese Medicine (TCM) database....
Urinary bladder cancer (UBC) is a common malignant tumor with high incidence. Advances in the diagnosis and treatment of this disease demand identification novel therapeutic targets. Multiple studies demonstrated that PDE4B level was upregulated malignancies expression correlated poor outcomes. Herein, we identified potential target UBC. We confirmed aggressive clinicopathological characteristics unfavorable prognosis. Functional ectopic promoted UBC cells proliferation, migration invasion,...
Bladder cancer (BC) ranks the tenth in incidence of global tumor epidemiology. LncRNAs and cuproptosis were discovered to regulate cell death. Herein, we downloaded transcriptome profiling, mutational data, clinical data on patients from The Cancer Genome Atlas (TCGA). High- low-risk BC categorized. Three CRLs (AL590428.1, AL138756.1 GUSBP11) taken into prognostic signature through least absolute shrinkage selection operator (LASSO) Cox regression. Worse OS PFS shown high-risk group ( p...
Insufficient tumor permeability and inadequate nanoparticle retention continue to be significant limitations in the efficacy of anti-tumor drug therapy. Numerous studies have focused on enhancing perfusion by improvement tumor-induced endothelial leakage, often known as enhanced (EPR) effect. However, these approaches produced suboptimal therapeutic outcomes been associated with side effects. Therefore, this study, we prepared cell membrane-coated gold nanorods (GNR@TM) enhance delivery...
Myoblast differentiation is a crucial process for myogenesis. Mitochondria function as an energy-providing machine that critical to this process, and mitochondrial dysfunction can prevent myoblasts from fusing into myotubes. However, the molecular mechanisms underlying dynamic regulation of networks remain poorly understood. In present study, we found PTEN induced kinase 1 (PINK1)/Parkin (an E3 ubiquitin-protein ligase) pathway activated at early stage myoblast differentiation. Moreover,...
Background: Bladder cancer (BC) is a leading cause of death from malignancy, with significant heterogeneity in the immunotherapeutic responsiveness advanced status. Pyroptosis, newly discovered inflammatory programmed cell death, confirmed to play an indispensable role tumorigenesis and anti-tumor activity. However, effect pyroptosis on tumor-immune landscape remodeling immunotherapy BC remains elusive. Methods: We comprehensively evaluated mRNA expression genomic alterations 33...
Abstract Background Bladder cancer (BC) is one of the most common malignancies genitourinary system. Animal models offer an important tool to explore tumour initiation, progression, and therapeutic mechanisms. Our aim construct optimized orthotopic BC model which predictable, reproducible, convenient. Methods The was constructed in male C57BL/6 mice utilizing microsyringes inoculate them with a murine cell line (MB49). Anesthetised were inoculated MB49 suspension (10 µL) at approximately 5 ×...
Bladder cancer, one of the most prevalent malignant cancers, has high rate recurrence and metastasis. Owing to genomic instability high-level heterogeneity bladder chemotherapy immunotherapy drugs sensitivity lack prognostic markers, prognosis cancer is unclear. Necroptosis a programmed modality necrotic cell death in caspase-independent form. Despite fact that necroptosis plays critical role tumor growth, metastasis, patient prognosis, necroptosis-related gene sets have rarely been studied...
Abstract Background: Enolase is an essential enzyme in the process of glycolysis and has been implicated cancer progression. Though dysregulation ENOs reported multiple cancers, their prognostic value specific role bladder (BLCA) remain unclear. Methods: Multiple databases were employed to examine expression BLCA. The ENO1 was also validated BLCA cell lines tissue samples by western blotting immunohistochemistry. Kaplan-Meier analysis, ROC curve, univariate multivariate Cox regression...
<title>Abstract</title> Bladder cancer, one of the most prevalent malignant cancers, has high rate recurrence and metastasis. Owing to genomic instability high-level heterogeneity bladder chemotherapy immunotherapy drugs sensitivity lack prognostic markers, prognosis cancer is unclear. Necroptosis a programmed modality necrotic cell death in caspase-independent form. Despite fact that necroptosis plays critical role tumor growth, metastasis, patient prognosis, necroptosis-related gene sets...