About
Contact & Profiles
A5070631416
Research Areas
- Cytomegalovirus and herpesvirus research
- Tryptophan and brain disorders
- Mitochondrial Function and Pathology
- interferon and immune responses
- Amino Acid Enzymes and Metabolism
- Inflammasome and immune disorders
- Genetic Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Diet and metabolism studies
University of Pennsylvania
2023-2024
10.1038/s42255-023-00761-7
article
EN
Nature Metabolism
2023-03-13
Friedreich's ataxia (FRDA) is a progressive disorder caused by insufficient expression of frataxin, which plays critical role in assembly iron-sulfur centers mitochondria. Individuals are cognitively normal but display loss motor coordination and cardiac abnormalities. Many ultimately develop heart failure. Administration nicotinamide adenine dinucleotide-positive (NAD+) precursors has shown promise human mitochondrial myopathy rodent models failure, including mice lacking frataxin...
10.1172/jci.insight.177152
article
EN
PubMed
2024-07-18
10.1016/s0168-8278(22)01805-0
article
EN
Journal of Hepatology
2022-07-01
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